SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells

Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation are poorly defined. We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, whereas their...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-09, Vol.77 (18), p.4985-4997
Hauptverfasser:	Kurtsdotter, Idha, Topcic, Danijal, Karlén, Alexandra, Singla, Bhumica, Hagey, Daniel W, Bergsland, Maria, Siesjö, Peter, Nistér, Monica, Carlson, Joseph W, Lefebvre, Veronique, Persson, Oscar, Holmberg, Johan, Muhr, Jonas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain stem Brain tumors Cancer and Oncology Cancer och onkologi Cell cycle Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cellular Senescence Clinical Medicine Female Genetic transformation Glioblastoma Glioblastoma cells Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Humans Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Molecular modelling Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncogenes p53 Protein Protein turnover Rodents Senescence SOXB2 Transcription Factors - genetics SOXB2 Transcription Factors - metabolism SOXD Transcription Factors - physiology Stem cell transplantation Stem cells Subventricular zone Transcription factors Tumor Cells, Cultured Tumor suppressor genes Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!