Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis
Background: Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for O...
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| Veröffentlicht in: | BRITISH JOURNAL OF CANCER 2017-09, Vol.117 (6), p.856-866 |
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| creator | Almangush, Alhadi Heikkinen, Ilkka Mäkitie, Antti A Coletta, Ricardo D Läärä, Esa Leivo, Ilmo Salo, Tuula |
| description | Background:
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC.
Methods:
A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results.
Results:
A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread.
Conclusions:
Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines. |
| doi_str_mv | 10.1038/bjc.2017.244 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_495115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1924599969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-80d8509fc6cc041d2771c7af473a972372d12a7b99c13d5ea008ec3d68d5eb963</originalsourceid><addsrcrecordid>eNptkc1v3CAQxVHVqNlse-u5Quqlh3gL2CzQQ6Uq6kekSOmhPSOMx1s2tknATrT_fcfabbSpcoJhfjyY9wh5y9mKs1J_rLd-JRhXK1FVL8iCy1IUXAv1kiwYY6pgRrBTcpbzFkvDtHpFToVWkiupF6T5meJmiHkMntYh9i7dQMq0jYnG5Do6xmEzAc13k-vjlKmHrqPeJR8GhD9RR_Muj9C7WSDBfYAH6oaG9jC6wg2u2-WQX5OT1nUZ3hzWJfn97euvix_F1fX3y4svV4WXshoLzRotmWn92ntW8UYoxb1ybaVKZ5QolWi4cKo2xvOykeAY0-DLZq2xqM26XJJir5sf4Haq7W0KONDORhfs4egGd2ArIzkatSSf9zx2emg8DCPO_OTa084Q_thNvLdSamOMQIEPB4EU7ybIo-1Dni1yA6BblhtRSSTXBtH3_6HbOCU0aKZKqTEmrpA631M-xZwTtI-f4czOcVuM285xW4wb8XfHAzzC__I9cgRbwwbS0avPCf4FBGW3Ng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1935809217</pqid></control><display><type>article</type><title>Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><creator>Almangush, Alhadi ; Heikkinen, Ilkka ; Mäkitie, Antti A ; Coletta, Ricardo D ; Läärä, Esa ; Leivo, Ilmo ; Salo, Tuula</creator><creatorcontrib>Almangush, Alhadi ; Heikkinen, Ilkka ; Mäkitie, Antti A ; Coletta, Ricardo D ; Läärä, Esa ; Leivo, Ilmo ; Salo, Tuula</creatorcontrib><description>Background:
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC.
Methods:
A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results.
Results:
A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread.
Conclusions:
Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2017.244</identifier><identifier>PMID: 28751758</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4028/67/1665 ; 692/53/2422 ; Biomarkers ; Biomarkers, Tumor - analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - mortality ; Cyclin D1 ; Cyclin D1 - analysis ; Cyclin-Dependent Kinase Inhibitor p16 - analysis ; Drug Resistance ; Epidemiology ; Guidelines ; Humans ; Ki-67 Antigen - analysis ; Medical prognosis ; Meta-analysis ; Molecular Diagnostics ; Molecular Medicine ; Oncology ; Oral cancer ; p53 Protein ; Prognosis ; Squamous cell carcinoma ; Studies ; Tongue ; Tongue Neoplasms - chemistry ; Tongue Neoplasms - mortality ; Tumor Suppressor Protein p53 - analysis ; Tumors ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - analysis</subject><ispartof>BRITISH JOURNAL OF CANCER, 2017-09, Vol.117 (6), p.856-866</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Sep 5, 2017</rights><rights>Copyright © 2017 Cancer Research UK 2017 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-80d8509fc6cc041d2771c7af473a972372d12a7b99c13d5ea008ec3d68d5eb963</citedby><cites>FETCH-LOGICAL-c554t-80d8509fc6cc041d2771c7af473a972372d12a7b99c13d5ea008ec3d68d5eb963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28751758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136569581$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Almangush, Alhadi</creatorcontrib><creatorcontrib>Heikkinen, Ilkka</creatorcontrib><creatorcontrib>Mäkitie, Antti A</creatorcontrib><creatorcontrib>Coletta, Ricardo D</creatorcontrib><creatorcontrib>Läärä, Esa</creatorcontrib><creatorcontrib>Leivo, Ilmo</creatorcontrib><creatorcontrib>Salo, Tuula</creatorcontrib><title>Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis</title><title>BRITISH JOURNAL OF CANCER</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC.
Methods:
A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results.
Results:
A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread.
Conclusions:
Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines.</description><subject>692/4028/67/1665</subject><subject>692/53/2422</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Cyclin D1</subject><subject>Cyclin D1 - analysis</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - analysis</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Guidelines</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Medical prognosis</subject><subject>Meta-analysis</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>p53 Protein</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Tongue</subject><subject>Tongue Neoplasms - chemistry</subject><subject>Tongue Neoplasms - mortality</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - analysis</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNptkc1v3CAQxVHVqNlse-u5Quqlh3gL2CzQQ6Uq6kekSOmhPSOMx1s2tknATrT_fcfabbSpcoJhfjyY9wh5y9mKs1J_rLd-JRhXK1FVL8iCy1IUXAv1kiwYY6pgRrBTcpbzFkvDtHpFToVWkiupF6T5meJmiHkMntYh9i7dQMq0jYnG5Do6xmEzAc13k-vjlKmHrqPeJR8GhD9RR_Muj9C7WSDBfYAH6oaG9jC6wg2u2-WQX5OT1nUZ3hzWJfn97euvix_F1fX3y4svV4WXshoLzRotmWn92ntW8UYoxb1ybaVKZ5QolWi4cKo2xvOykeAY0-DLZq2xqM26XJJir5sf4Haq7W0KONDORhfs4egGd2ArIzkatSSf9zx2emg8DCPO_OTa084Q_thNvLdSamOMQIEPB4EU7ybIo-1Dni1yA6BblhtRSSTXBtH3_6HbOCU0aKZKqTEmrpA631M-xZwTtI-f4czOcVuM285xW4wb8XfHAzzC__I9cgRbwwbS0avPCf4FBGW3Ng</recordid><startdate>20170905</startdate><enddate>20170905</enddate><creator>Almangush, Alhadi</creator><creator>Heikkinen, Ilkka</creator><creator>Mäkitie, Antti A</creator><creator>Coletta, Ricardo D</creator><creator>Läärä, Esa</creator><creator>Leivo, Ilmo</creator><creator>Salo, Tuula</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20170905</creationdate><title>Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis</title><author>Almangush, Alhadi ; Heikkinen, Ilkka ; Mäkitie, Antti A ; Coletta, Ricardo D ; Läärä, Esa ; Leivo, Ilmo ; Salo, Tuula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-80d8509fc6cc041d2771c7af473a972372d12a7b99c13d5ea008ec3d68d5eb963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/4028/67/1665</topic><topic>692/53/2422</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Cyclin D1</topic><topic>Cyclin D1 - analysis</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - analysis</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Guidelines</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>Medical prognosis</topic><topic>Meta-analysis</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>p53 Protein</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>Tongue</topic><topic>Tongue Neoplasms - chemistry</topic><topic>Tongue Neoplasms - mortality</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almangush, Alhadi</creatorcontrib><creatorcontrib>Heikkinen, Ilkka</creatorcontrib><creatorcontrib>Mäkitie, Antti A</creatorcontrib><creatorcontrib>Coletta, Ricardo D</creatorcontrib><creatorcontrib>Läärä, Esa</creatorcontrib><creatorcontrib>Leivo, Ilmo</creatorcontrib><creatorcontrib>Salo, Tuula</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>BRITISH JOURNAL OF CANCER</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almangush, Alhadi</au><au>Heikkinen, Ilkka</au><au>Mäkitie, Antti A</au><au>Coletta, Ricardo D</au><au>Läärä, Esa</au><au>Leivo, Ilmo</au><au>Salo, Tuula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis</atitle><jtitle>BRITISH JOURNAL OF CANCER</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2017-09-05</date><risdate>2017</risdate><volume>117</volume><issue>6</issue><spage>856</spage><epage>866</epage><pages>856-866</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Background:
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC.
Methods:
A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results.
Results:
A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread.
Conclusions:
Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28751758</pmid><doi>10.1038/bjc.2017.244</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online |
| subjects | 692/4028/67/1665 692/53/2422 Biomarkers Biomarkers, Tumor - analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - mortality Cyclin D1 Cyclin D1 - analysis Cyclin-Dependent Kinase Inhibitor p16 - analysis Drug Resistance Epidemiology Guidelines Humans Ki-67 Antigen - analysis Medical prognosis Meta-analysis Molecular Diagnostics Molecular Medicine Oncology Oral cancer p53 Protein Prognosis Squamous cell carcinoma Studies Tongue Tongue Neoplasms - chemistry Tongue Neoplasms - mortality Tumor Suppressor Protein p53 - analysis Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis |
| title | Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis |
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