Identification of CYP443D1 (CYP74 clan) of Nematostella vectensis as a first cnidarian epoxyalcohol synthase and insights into its catalytic mechanism

The CYP74 clan enzymes are responsible for the biosynthesis of numerous bioactive oxylipins in higher plants, some Proteobacteria, brown and green algae, and Metazoa. A novel putative CYP74 clan gene CYP443D1 of the starlet sea anemone (Nematostella vectensis, Cnidaria) has been cloned, and the prop...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2017-10, Vol.1862 (10), p.1099-1109
Hauptverfasser:	Toporkova, Yana Y., Gorina, Svetlana S., Mukhitova, Fakhima K., Hamberg, Mats, Ilyina, Tatyana M., Mukhtarova, Lucia S., Grechkin, Alexander N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalysis Cloning, Molecular Cnidaria CYP74 enzymes Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Eicosapentaenoic Acid - analogs & derivatives Eicosapentaenoic Acid - chemistry Epoxyalcohol synthase Linoleic Acids - chemistry Lipid Peroxides - chemistry Nematostella vectensis Sea anemone Sea Anemones - enzymology Sea Anemones - genetics Substrate Specificity - physiology
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