Notch Signaling in Development, Tissue Homeostasis, and Disease

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs via cell-cell communication, where transmembrane ligands on one cell activate transmembrane receptors on a juxtaposed ce...

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Veröffentlicht in:	Physiological reviews 2017-10, Vol.97 (4), p.1235-1294
Hauptverfasser:	Siebel, Chris, Lendahl, Urban
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone morphogenetic proteins Cell Communication Cell interactions Cell signaling Disease Growth and Development Homeostasis Humans Intestine Ligands Mutation Notch protein Receptors, Notch - metabolism Signal Transduction Tissues Wnt protein
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