Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database
The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated...
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| Veröffentlicht in: | Atherosclerosis 2017-10, Vol.265, p.54-59 |
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| creator | Karlson, Björn W. Palmer, Michael K. Nicholls, Stephen J. Barter, Philip J. Lundman, Pia |
| description | The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C.
Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10–80 mg, rosuvastatin 5–40 mg or simvastatin 10–80 mg was estimated in women aged |
| doi_str_mv | 10.1016/j.atherosclerosis.2017.08.014 |
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Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10–80 mg, rosuvastatin 5–40 mg or simvastatin 10–80 mg was estimated in women aged <70 years, women aged ≥70 years, men aged <70 years and men aged ≥70 years.
All statins and doses gave significant dose-dependent reductions in LDL-C and non-HDL-C, and increases in HDL-C, in all four patient groups. A 2.1% greater reduction in LDL-C was observed in women, compared with men (p < 0.0001). Patients aged ≥70 years experienced a 2.7% greater reduction in LDL-C compared with younger patients (p < 0.0001). Similar results were also observed for statin-mediated changes in non-HDL-C. Men experienced a significantly greater increase in HDL-C than women, and patients aged ≥70 years achieved a significantly greater increase than younger patients (both p = 0.001).
While statins improve the lipid profile in all gender and age groups analysed, the improvements are greater in women than in men and in those aged ≥70 years compared with those aged <70 years.
•We determined if statin-mediated lipid effects are associated with age and gender.•Statins exhibit beneficial lipid effects in all age and sex groups investigated.•Statin-mediated improvements in lipid profile are greater in women than in men.•Improvements in lipid profile are greater and in those aged ≥70 years vs. <70 years.]]></description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2017.08.014</identifier><identifier>PMID: 28863328</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Age ; Age Factors ; Aged ; Atorvastatin Calcium - administration & dosage ; Biomarkers - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical Medicine ; Databases, Factual ; Dose-Response Relationship, Drug ; Dyslipidaemia ; Dyslipidemias - blood ; Dyslipidemias - diagnosis ; Dyslipidemias - drug therapy ; Elderly ; Female ; Gender ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Klinisk medicin ; Least-Squares Analysis ; Lipids - blood ; Male ; Middle Aged ; Rosuvastatin Calcium - administration & dosage ; Sex Factors ; Simvastatin - administration & dosage ; Statins ; Treatment Outcome ; Women</subject><ispartof>Atherosclerosis, 2017-10, Vol.265, p.54-59</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-8796eb802f61455b278d28168e79b448c9180f86372523265b93af3eed99b4213</citedby><cites>FETCH-LOGICAL-c531t-8796eb802f61455b278d28168e79b448c9180f86372523265b93af3eed99b4213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915017312364$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28863328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/258847$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136660214$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Karlson, Björn W.</creatorcontrib><creatorcontrib>Palmer, Michael K.</creatorcontrib><creatorcontrib>Nicholls, Stephen J.</creatorcontrib><creatorcontrib>Barter, Philip J.</creatorcontrib><creatorcontrib>Lundman, Pia</creatorcontrib><title>Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description><![CDATA[The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C.
Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10–80 mg, rosuvastatin 5–40 mg or simvastatin 10–80 mg was estimated in women aged <70 years, women aged ≥70 years, men aged <70 years and men aged ≥70 years.
All statins and doses gave significant dose-dependent reductions in LDL-C and non-HDL-C, and increases in HDL-C, in all four patient groups. A 2.1% greater reduction in LDL-C was observed in women, compared with men (p < 0.0001). Patients aged ≥70 years experienced a 2.7% greater reduction in LDL-C compared with younger patients (p < 0.0001). Similar results were also observed for statin-mediated changes in non-HDL-C. Men experienced a significantly greater increase in HDL-C than women, and patients aged ≥70 years achieved a significantly greater increase than younger patients (both p = 0.001).
While statins improve the lipid profile in all gender and age groups analysed, the improvements are greater in women than in men and in those aged ≥70 years compared with those aged <70 years.
•We determined if statin-mediated lipid effects are associated with age and gender.•Statins exhibit beneficial lipid effects in all age and sex groups investigated.•Statin-mediated improvements in lipid profile are greater in women than in men.•Improvements in lipid profile are greater and in those aged ≥70 years vs. <70 years.]]></description><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atorvastatin Calcium - administration & dosage</subject><subject>Biomarkers - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical Medicine</subject><subject>Databases, Factual</subject><subject>Dose-Response Relationship, Drug</subject><subject>Dyslipidaemia</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - diagnosis</subject><subject>Dyslipidemias - drug therapy</subject><subject>Elderly</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Klinisk medicin</subject><subject>Least-Squares Analysis</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Rosuvastatin Calcium - administration & dosage</subject><subject>Sex Factors</subject><subject>Simvastatin - administration & dosage</subject><subject>Statins</subject><subject>Treatment Outcome</subject><subject>Women</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-L1DAUx4Mo7uzqvyC5CB5sza-2qeBhWcZZYWFhUcFTSJuXmjFtatKu7H9vhhn34EG8JOHl8977wgeh15SUlND63b7Uy3eIIfX-cLpUMkKbksiSUPEEbahs2oIKKZ6iDSGMFi2tyBk6T2lPCBENlc_RGZOy5pzJDRq21kK_JBws1gO8xQNMBiLWk8Fp0YubsAkJcJiwd7Mz2MM9-PQe30Fafe6zMYw4J8Jfb79d7rZ3eIRFF3rS_iGHw0YvutMJXqBnVvsEL0_3Bfrycfv56rq4ud19urq8KfqK06XI4WvoJGG2pqKqOtZIwyStJTRtJ4TsWyqJzeEbVjHO6qprubYcwLT5n1F-gYrj3PQL5rVTc3Sjjg8qaKdOpR_5BUq0gvN_88M6q1wa1gPPKilFk_k3R36O4ecKaVGjSz14rycIa1K05TWtK96QjH44on32lCLYx-GUqINLtVd_uVQHl4pIlV3m_lenVWs3gnns_iMvA7sjkIXAvYOoUu9g6sG4mJ0qE9x_rvoNlrS5ng</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Karlson, Björn W.</creator><creator>Palmer, Michael K.</creator><creator>Nicholls, Stephen J.</creator><creator>Barter, Philip J.</creator><creator>Lundman, Pia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>20171001</creationdate><title>Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database</title><author>Karlson, Björn W. ; Palmer, Michael K. ; Nicholls, Stephen J. ; Barter, Philip J. ; Lundman, Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-8796eb802f61455b278d28168e79b448c9180f86372523265b93af3eed99b4213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atorvastatin Calcium - administration & dosage</topic><topic>Biomarkers - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical Medicine</topic><topic>Databases, Factual</topic><topic>Dose-Response Relationship, Drug</topic><topic>Dyslipidaemia</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - diagnosis</topic><topic>Dyslipidemias - drug therapy</topic><topic>Elderly</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Klinisk medicin</topic><topic>Least-Squares Analysis</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Rosuvastatin Calcium - administration & dosage</topic><topic>Sex Factors</topic><topic>Simvastatin - administration & dosage</topic><topic>Statins</topic><topic>Treatment Outcome</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karlson, Björn W.</creatorcontrib><creatorcontrib>Palmer, Michael K.</creatorcontrib><creatorcontrib>Nicholls, Stephen J.</creatorcontrib><creatorcontrib>Barter, Philip J.</creatorcontrib><creatorcontrib>Lundman, Pia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karlson, Björn W.</au><au>Palmer, Michael K.</au><au>Nicholls, Stephen J.</au><au>Barter, Philip J.</au><au>Lundman, Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>265</volume><spage>54</spage><epage>59</epage><pages>54-59</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract><![CDATA[The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. However, the association of statin-mediated lipid effects with age and gender is unclear. This study aimed to determine whether age and gender are associated with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C.
Individual patient data (n = 32,258) were obtained from VOYAGER. Least-squares mean percentage change from baseline in LDL-C, non-HDL-C and HDL-C with atorvastatin 10–80 mg, rosuvastatin 5–40 mg or simvastatin 10–80 mg was estimated in women aged <70 years, women aged ≥70 years, men aged <70 years and men aged ≥70 years.
All statins and doses gave significant dose-dependent reductions in LDL-C and non-HDL-C, and increases in HDL-C, in all four patient groups. A 2.1% greater reduction in LDL-C was observed in women, compared with men (p < 0.0001). Patients aged ≥70 years experienced a 2.7% greater reduction in LDL-C compared with younger patients (p < 0.0001). Similar results were also observed for statin-mediated changes in non-HDL-C. Men experienced a significantly greater increase in HDL-C than women, and patients aged ≥70 years achieved a significantly greater increase than younger patients (both p = 0.001).
While statins improve the lipid profile in all gender and age groups analysed, the improvements are greater in women than in men and in those aged ≥70 years compared with those aged <70 years.
•We determined if statin-mediated lipid effects are associated with age and gender.•Statins exhibit beneficial lipid effects in all age and sex groups investigated.•Statin-mediated improvements in lipid profile are greater in women than in men.•Improvements in lipid profile are greater and in those aged ≥70 years vs. <70 years.]]></abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28863328</pmid><doi>10.1016/j.atherosclerosis.2017.08.014</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Age Factors Aged Atorvastatin Calcium - administration & dosage Biomarkers - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical Medicine Databases, Factual Dose-Response Relationship, Drug Dyslipidaemia Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Elderly Female Gender Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Klinisk medicin Least-Squares Analysis Lipids - blood Male Middle Aged Rosuvastatin Calcium - administration & dosage Sex Factors Simvastatin - administration & dosage Statins Treatment Outcome Women |
| title | Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database |
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