Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids. CBR1 catalyzes the NADPH- dependent production of 20β-dihydrocortiso...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.10633-11, Article 10633
Hauptverfasser:	Morgan, Ruth A., Beck, Katharina R., Nixon, Mark, Homer, Natalie Z. M., Crawford, Andrew A., Melchers, Diana, Houtman, René, Meijer, Onno C., Stomby, Andreas, Anderson, Anna J., Upreti, Rita, Stimson, Roland H., Olsson, Tommy, Michoel, Tom, Cohain, Ariella, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M., Andrew, Ruth, Kenyon, Christopher J., Hadoke, Patrick W. F., Odermatt, Alex, Keen, John A., Walker, Brian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/109 38 38/43 38/77 38/90 42 45 64/60 692/163 692/163/2743/393 Adipose tissue Animals Carbonyl compounds Carbonyl Reductase (NADPH) - genetics Carbonyl Reductase (NADPH) - metabolism Cortisol Disease Models, Animal Drug metabolism Energy Metabolism Female Gene Expression Genetic Association Studies Genetic Variation Glucocorticoids Glucocorticoids - chemistry Glucocorticoids - metabolism Glucocorticoids - urine Glucose tolerance Horses Humanities and Social Sciences Humans Hydrocortisone - metabolism Hydroxycorticosteroids - metabolism Hydroxycorticosteroids - urine Intolerance Liver - metabolism Male Medicin och hälsovetenskap Metabolic rate Metabolism Mice Models, Molecular Molecular Conformation multidisciplinary NADP Obesity Obesity - genetics Obesity - metabolism Phenotype Protein Binding Receptor mechanisms Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - chemistry Receptors, Glucocorticoid - metabolism Reductase Rodents Science Science (multidisciplinary) Structure-Activity Relationship
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