Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial

Primary analyses of a study in young women aged 16–26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody respons...

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Veröffentlicht in:	The Lancet (British edition) 2017-11, Vol.390 (10108), p.2143-2159
Hauptverfasser:	Huh, Warner K, Joura, Elmar A, Giuliano, Anna R, Iversen, Ole-Erik, de Andrade, Rosires Pereira, Ault, Kevin A, Bartholomew, Deborah, Cestero, Ramon M, Fedrizzi, Edison N, Hirschberg, Angelica L, Mayrand, Marie-Hélène, Ruiz-Sternberg, Angela Maria, Stapleton, Jack T, Wiley, Dorothy J, Ferenczy, Alex, Kurman, Robert, Ronnett, Brigitte M, Stoler, Mark H, Cuzick, Jack, Garland, Suzanne M, Kjaer, Susanne K, Bautista, Oliver M, Haupt, Richard, Moeller, Erin, Ritter, Michael, Roberts, Christine C, Shields, Christine, Luxembourg, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adenocarcinoma Adjudication Adolescent Adult Antibodies, Viral - blood Biopsy Cancer Cervical cancer Cervical carcinoma Cervix Clinical trials Cytology Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Double-Blind Method Double-blind studies Effectiveness Epidemiology Evidence-based medicine Female Follow-Up Studies Genital cancers Histopathology Human papillomavirus Human papillomavirus 6 - immunology Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - administration & dosage Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - immunology Humans Immunization Immunoassay Immunogenicity Immunogenicity, Vaccine - immunology Incidence Injections, Intramuscular Invasiveness Lesions Motivation Papillomavirus Infections - epidemiology Papillomavirus Infections - prevention & control Patient Compliance - statistics & numerical data Patient Safety Primary Prevention - methods Randomization Safety Sexual partners Treatment Outcome Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaccination Vaccination - methods Vaccine efficacy Vaccines Vagina Women Womens health Young Adult
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