Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study
Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development . We aimed to assess the association between maternal and paternal occupational expos...
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| Veröffentlicht in: | Environmental health perspectives 2017-06, Vol.125 (6), p.067023 |
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| creator | Le Cornet, Charlotte Fervers, Béatrice Pukkala, Eero Tynes, Tore Feychting, Maria Hansen, Johnni Togawa, Kayo Nordby, Karl-Christian Oksbjerg Dalton, Susanne Uuksulainen, Sanni Wiebert, Pernilla Woldbæk, Torill Skakkebæk, Niels E Olsson, Ann Schüz, Joachim |
| description | Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development
.
We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring.
This registry-based case control study included TGCT cases aged 14–49 y (
=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (
=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child’s birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child’s birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41).
This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864. |
| doi_str_mv | 10.1289/EHP864 |
| format | Article |
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.
We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring.
This registry-based case control study included TGCT cases aged 14–49 y (
=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (
=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child’s birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child’s birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41).
This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP864</identifier><identifier>PMID: 28893722</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adolescent ; Adult ; Analysis ; Aromatic hydrocarbons ; Birth ; Cancer ; Carcinogens ; Care and treatment ; Case-Control Studies ; Censuses ; Childbirth & labor ; Classification ; Codes ; Confidence intervals ; Congenital diseases ; Control methods ; Cryptorchidism ; Diagnosis ; Endocrine disruptors ; Environmental aspects ; Estimates ; Etiology (Medicine) ; Exposure ; Female ; Finland - epidemiology ; Gene expression ; Health risk assessment ; Hernias ; Hormones ; Humans ; Hydrocarbons ; Hypotheses ; Male ; Maternal Exposure ; Middle Aged ; Mothers ; Neoplasms, Germ Cell and Embryonal - epidemiology ; Norway - epidemiology ; Occupational exposure ; Occupational Exposure - statistics & numerical data ; Occupational health ; Occupations ; Odds Ratio ; Offspring ; Organic solvents ; Parenting ; Parents ; Paternal Exposure - statistics & numerical data ; PCB ; Perchloroethylene ; Polychlorinated biphenyls ; Population ; Pregnancy ; Prenatal experience ; Prenatal exposure ; Prenatal Exposure Delayed Effects - epidemiology ; Regression analysis ; Risk ; Solvents ; Sperm ; Statistical analysis ; Studies ; Sweden - epidemiology ; Testes ; Testicular cancer ; Testicular Neoplasms - epidemiology ; Tetrachloroethylene ; Toluene ; Toxicology ; Tumors ; Young Adult</subject><ispartof>Environmental health perspectives, 2017-06, Vol.125 (6), p.067023</ispartof><rights>COPYRIGHT 2017 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Jun 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-63c2e87ecf03a9e7520a2ca492510170a5b2c8df0d1fe68c7333de6ce0201de63</citedby><cites>FETCH-LOGICAL-c636t-63c2e87ecf03a9e7520a2ca492510170a5b2c8df0d1fe68c7333de6ce0201de63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743448/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743448/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28893722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:140515162$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Cornet, Charlotte</creatorcontrib><creatorcontrib>Fervers, Béatrice</creatorcontrib><creatorcontrib>Pukkala, Eero</creatorcontrib><creatorcontrib>Tynes, Tore</creatorcontrib><creatorcontrib>Feychting, Maria</creatorcontrib><creatorcontrib>Hansen, Johnni</creatorcontrib><creatorcontrib>Togawa, Kayo</creatorcontrib><creatorcontrib>Nordby, Karl-Christian</creatorcontrib><creatorcontrib>Oksbjerg Dalton, Susanne</creatorcontrib><creatorcontrib>Uuksulainen, Sanni</creatorcontrib><creatorcontrib>Wiebert, Pernilla</creatorcontrib><creatorcontrib>Woldbæk, Torill</creatorcontrib><creatorcontrib>Skakkebæk, Niels E</creatorcontrib><creatorcontrib>Olsson, Ann</creatorcontrib><creatorcontrib>Schüz, Joachim</creatorcontrib><title>Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development
.
We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring.
This registry-based case control study included TGCT cases aged 14–49 y (
=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (
=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child’s birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child’s birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41).
This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Aromatic hydrocarbons</subject><subject>Birth</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Censuses</subject><subject>Childbirth & labor</subject><subject>Classification</subject><subject>Codes</subject><subject>Confidence intervals</subject><subject>Congenital diseases</subject><subject>Control methods</subject><subject>Cryptorchidism</subject><subject>Diagnosis</subject><subject>Endocrine disruptors</subject><subject>Environmental aspects</subject><subject>Estimates</subject><subject>Etiology (Medicine)</subject><subject>Exposure</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Gene expression</subject><subject>Health risk assessment</subject><subject>Hernias</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Middle Aged</subject><subject>Mothers</subject><subject>Neoplasms, Germ Cell and Embryonal - epidemiology</subject><subject>Norway - epidemiology</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Occupational health</subject><subject>Occupations</subject><subject>Odds Ratio</subject><subject>Offspring</subject><subject>Organic solvents</subject><subject>Parenting</subject><subject>Parents</subject><subject>Paternal Exposure - statistics & numerical data</subject><subject>PCB</subject><subject>Perchloroethylene</subject><subject>Polychlorinated biphenyls</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Solvents</subject><subject>Sperm</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Sweden - epidemiology</subject><subject>Testes</subject><subject>Testicular cancer</subject><subject>Testicular Neoplasms - epidemiology</subject><subject>Tetrachloroethylene</subject><subject>Toluene</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>Young 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Collection</collection><collection>ABI/INFORM Global</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Cornet, Charlotte</au><au>Fervers, Béatrice</au><au>Pukkala, Eero</au><au>Tynes, Tore</au><au>Feychting, Maria</au><au>Hansen, Johnni</au><au>Togawa, Kayo</au><au>Nordby, Karl-Christian</au><au>Oksbjerg Dalton, Susanne</au><au>Uuksulainen, Sanni</au><au>Wiebert, Pernilla</au><au>Woldbæk, Torill</au><au>Skakkebæk, Niels E</au><au>Olsson, Ann</au><au>Schüz, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>125</volume><issue>6</issue><spage>067023</spage><pages>067023-</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development
.
We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring.
This registry-based case control study included TGCT cases aged 14–49 y (
=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (
=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child’s birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).
Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child’s birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41).
This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>28893722</pmid><doi>10.1289/EHP864</doi><tpages>67023(-67021)</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2017-06, Vol.125 (6), p.067023 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_494119 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Adolescent Adult Analysis Aromatic hydrocarbons Birth Cancer Carcinogens Care and treatment Case-Control Studies Censuses Childbirth & labor Classification Codes Confidence intervals Congenital diseases Control methods Cryptorchidism Diagnosis Endocrine disruptors Environmental aspects Estimates Etiology (Medicine) Exposure Female Finland - epidemiology Gene expression Health risk assessment Hernias Hormones Humans Hydrocarbons Hypotheses Male Maternal Exposure Middle Aged Mothers Neoplasms, Germ Cell and Embryonal - epidemiology Norway - epidemiology Occupational exposure Occupational Exposure - statistics & numerical data Occupational health Occupations Odds Ratio Offspring Organic solvents Parenting Parents Paternal Exposure - statistics & numerical data PCB Perchloroethylene Polychlorinated biphenyls Population Pregnancy Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - epidemiology Regression analysis Risk Solvents Sperm Statistical analysis Studies Sweden - epidemiology Testes Testicular cancer Testicular Neoplasms - epidemiology Tetrachloroethylene Toluene Toxicology Tumors Young Adult |
| title | Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study |
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