PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study
Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition 2017-11, Vol.147 (11), p.2018-2024 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2024 |
|---|---|
| container_issue | 11 |
| container_start_page | 2018 |
| container_title | The Journal of nutrition |
| container_volume | 147 |
| creator | Yeates, Alison J Thurston, Sally W Li, Huiqi Mulhern, Maria S McSorley, Emeir M Watson, Gene E Shamlaye, Conrad F Strain, JJ Myers, Gary J Davidson, Philip W van Wijngaarden, Edwin Broberg, Karin |
| description | Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.
The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high.
Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatal mercury was also measured in children's hair samples with the use of a cumulative metric derived from values obtained at 3–5 y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL.
Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n–6:n–3 PUFA ratio was significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status and methylmercury exposure were not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of age were significantly associated with longer TLs in cord blood (β = 0.005, P = 0.03).
We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL. |
| doi_str_mv | 10.3945/jn.117.253021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_493594</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022316622106152</els_id><sourcerecordid>1982170447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-7f3b586e09b9c6b60220ce1efd9a498a9d5c9288d2956b9ce959fbcc463e9d143</originalsourceid><addsrcrecordid>eNp1kkFv0zAUxyMEYmVw5IoscU6xk9ixL0hV2QCpA6R1Z8uxXxZ3aVxspyOfhq-Kq5bBDjs82Xr_v39-z35Z9pbgeSkq-mEzzAmp5wUtcUGeZTNCK5IzgvHzbIZxUeQlYewsexXCBmNMKsFfZmcFFzVnNZ9lv3_cXC7QdVRxDEgNBl1B7KZ-C16PfkIXv3YujB7QIsU3F9EiBKetimDQvY0dWsF45_QUAa2hd-kYpNRwmxQ7oCsXO_ABOY_WHViPlp3tjYfhICYJXcOkO-h7CEcJfYJ9wuy2MMRU1Gim19mLVvUB3pzW8-zm8mK9_JKvvn_-ulysck1rHPO6LRvKGWDRCM0alhrHGgi0RqjUshKGalFwbgpBWbKAoKJttK5YCcKQqjzP8iM33MNubOTO263yk3TKylPqLu1AVqKk4uBfPenvx12KJsXhAKhWN4RRWbeMy8pwJRteGpkqFphQqDVhCffxiEusLRid-veqf0R9rAy2k7duLymjNSl5Arw_Abz7OUKIcuNGP6Qnk0TwgtS4qup_XWrvQvDQPtxAsDyMk9wMMo2TPI5T8r_7v6wH99_5SYb6aID0N3sLXgZtYdBgrAcdpXH2CfQfohfcnA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1982170447</pqid></control><display><type>article</type><title>PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>Yeates, Alison J ; Thurston, Sally W ; Li, Huiqi ; Mulhern, Maria S ; McSorley, Emeir M ; Watson, Gene E ; Shamlaye, Conrad F ; Strain, JJ ; Myers, Gary J ; Davidson, Philip W ; van Wijngaarden, Edwin ; Broberg, Karin</creator><creatorcontrib>Yeates, Alison J ; Thurston, Sally W ; Li, Huiqi ; Mulhern, Maria S ; McSorley, Emeir M ; Watson, Gene E ; Shamlaye, Conrad F ; Strain, JJ ; Myers, Gary J ; Davidson, Philip W ; van Wijngaarden, Edwin ; Broberg, Karin</creatorcontrib><description>Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.
The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high.
Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatal mercury was also measured in children's hair samples with the use of a cumulative metric derived from values obtained at 3–5 y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL.
Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n–6:n–3 PUFA ratio was significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status and methylmercury exposure were not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of age were significantly associated with longer TLs in cord blood (β = 0.005, P = 0.03).
We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.3945/jn.117.253021</identifier><identifier>PMID: 28978678</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age related diseases ; Animals ; Arbetsmedicin och miljömedicin ; Bioaccumulation ; Biochemical, Molecular, and Genetic Mechanisms ; Blood ; Child Development - drug effects ; Child, Preschool ; Children & youth ; Cohort Studies ; Diet ; Environmental Health and Occupational Health ; Exposure ; Fatty acids ; Fatty Acids, Unsaturated - administration & dosage ; Fatty Acids, Unsaturated - blood ; Fish ; Fish consumption ; Fishes ; Food Contamination - analysis ; Gestation ; Hair ; Hair - chemistry ; Health Sciences ; Humans ; Hälsovetenskap ; Leukocytes ; Leukocytes - drug effects ; Linear Models ; Maternal infant nutrition ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mercury ; Mercury (metal) ; Methylmercury ; Methylmercury Compounds - analysis ; Methylmercury exposure ; Mothers ; Nutrition ; Polymerase chain reaction ; Polyunsaturated fatty acid status ; Polyunsaturated fatty acids ; Pregnancy ; Regression analysis ; Regression models ; Seafood - analysis ; Seychelles ; Seychelles Child Development Study ; Socioeconomics ; Telomere - drug effects ; Telomere - ultrastructure ; Telomere length ; Young Adult</subject><ispartof>The Journal of nutrition, 2017-11, Vol.147 (11), p.2018-2024</ispartof><rights>2017 American Society for Nutrition.</rights><rights>Copyright American Institute of Nutrition Nov 1, 2017</rights><rights>2017 American Society for Nutrition 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-7f3b586e09b9c6b60220ce1efd9a498a9d5c9288d2956b9ce959fbcc463e9d143</citedby><cites>FETCH-LOGICAL-c570t-7f3b586e09b9c6b60220ce1efd9a498a9d5c9288d2956b9ce959fbcc463e9d143</cites><orcidid>0000-0002-3397-1116 ; 0000-0003-4317-015X ; 0000-0002-2393-1663 ; 0000-0002-5862-468X ; 0000-0003-1861-3991 ; 0000-0002-2212-3744 ; 0000-0002-1127-0829 ; 0000-0002-1633-2873</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28978678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/eafcb165-7f68-4d8a-b83d-f3b9015e7c16$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137175942$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeates, Alison J</creatorcontrib><creatorcontrib>Thurston, Sally W</creatorcontrib><creatorcontrib>Li, Huiqi</creatorcontrib><creatorcontrib>Mulhern, Maria S</creatorcontrib><creatorcontrib>McSorley, Emeir M</creatorcontrib><creatorcontrib>Watson, Gene E</creatorcontrib><creatorcontrib>Shamlaye, Conrad F</creatorcontrib><creatorcontrib>Strain, JJ</creatorcontrib><creatorcontrib>Myers, Gary J</creatorcontrib><creatorcontrib>Davidson, Philip W</creatorcontrib><creatorcontrib>van Wijngaarden, Edwin</creatorcontrib><creatorcontrib>Broberg, Karin</creatorcontrib><title>PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.
The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high.
Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatal mercury was also measured in children's hair samples with the use of a cumulative metric derived from values obtained at 3–5 y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL.
Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n–6:n–3 PUFA ratio was significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status and methylmercury exposure were not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of age were significantly associated with longer TLs in cord blood (β = 0.005, P = 0.03).
We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age related diseases</subject><subject>Animals</subject><subject>Arbetsmedicin och miljömedicin</subject><subject>Bioaccumulation</subject><subject>Biochemical, Molecular, and Genetic Mechanisms</subject><subject>Blood</subject><subject>Child Development - drug effects</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Diet</subject><subject>Environmental Health and Occupational Health</subject><subject>Exposure</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - administration & dosage</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Fish</subject><subject>Fish consumption</subject><subject>Fishes</subject><subject>Food Contamination - analysis</subject><subject>Gestation</subject><subject>Hair</subject><subject>Hair - chemistry</subject><subject>Health Sciences</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Leukocytes</subject><subject>Leukocytes - drug effects</subject><subject>Linear Models</subject><subject>Maternal infant nutrition</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Methylmercury</subject><subject>Methylmercury Compounds - analysis</subject><subject>Methylmercury exposure</subject><subject>Mothers</subject><subject>Nutrition</subject><subject>Polymerase chain reaction</subject><subject>Polyunsaturated fatty acid status</subject><subject>Polyunsaturated fatty acids</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Seafood - analysis</subject><subject>Seychelles</subject><subject>Seychelles Child Development Study</subject><subject>Socioeconomics</subject><subject>Telomere - drug effects</subject><subject>Telomere - ultrastructure</subject><subject>Telomere length</subject><subject>Young Adult</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kkFv0zAUxyMEYmVw5IoscU6xk9ixL0hV2QCpA6R1Z8uxXxZ3aVxspyOfhq-Kq5bBDjs82Xr_v39-z35Z9pbgeSkq-mEzzAmp5wUtcUGeZTNCK5IzgvHzbIZxUeQlYewsexXCBmNMKsFfZmcFFzVnNZ9lv3_cXC7QdVRxDEgNBl1B7KZ-C16PfkIXv3YujB7QIsU3F9EiBKetimDQvY0dWsF45_QUAa2hd-kYpNRwmxQ7oCsXO_ABOY_WHViPlp3tjYfhICYJXcOkO-h7CEcJfYJ9wuy2MMRU1Gim19mLVvUB3pzW8-zm8mK9_JKvvn_-ulysck1rHPO6LRvKGWDRCM0alhrHGgi0RqjUshKGalFwbgpBWbKAoKJttK5YCcKQqjzP8iM33MNubOTO263yk3TKylPqLu1AVqKk4uBfPenvx12KJsXhAKhWN4RRWbeMy8pwJRteGpkqFphQqDVhCffxiEusLRid-veqf0R9rAy2k7duLymjNSl5Arw_Abz7OUKIcuNGP6Qnk0TwgtS4qup_XWrvQvDQPtxAsDyMk9wMMo2TPI5T8r_7v6wH99_5SYb6aID0N3sLXgZtYdBgrAcdpXH2CfQfohfcnA</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Yeates, Alison J</creator><creator>Thurston, Sally W</creator><creator>Li, Huiqi</creator><creator>Mulhern, Maria S</creator><creator>McSorley, Emeir M</creator><creator>Watson, Gene E</creator><creator>Shamlaye, Conrad F</creator><creator>Strain, JJ</creator><creator>Myers, Gary J</creator><creator>Davidson, Philip W</creator><creator>van Wijngaarden, Edwin</creator><creator>Broberg, Karin</creator><general>Elsevier Inc</general><general>American Institute of Nutrition</general><general>American Society for Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3397-1116</orcidid><orcidid>https://orcid.org/0000-0003-4317-015X</orcidid><orcidid>https://orcid.org/0000-0002-2393-1663</orcidid><orcidid>https://orcid.org/0000-0002-5862-468X</orcidid><orcidid>https://orcid.org/0000-0003-1861-3991</orcidid><orcidid>https://orcid.org/0000-0002-2212-3744</orcidid><orcidid>https://orcid.org/0000-0002-1127-0829</orcidid><orcidid>https://orcid.org/0000-0002-1633-2873</orcidid></search><sort><creationdate>20171101</creationdate><title>PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study</title><author>Yeates, Alison J ; Thurston, Sally W ; Li, Huiqi ; Mulhern, Maria S ; McSorley, Emeir M ; Watson, Gene E ; Shamlaye, Conrad F ; Strain, JJ ; Myers, Gary J ; Davidson, Philip W ; van Wijngaarden, Edwin ; Broberg, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-7f3b586e09b9c6b60220ce1efd9a498a9d5c9288d2956b9ce959fbcc463e9d143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age related diseases</topic><topic>Animals</topic><topic>Arbetsmedicin och miljömedicin</topic><topic>Bioaccumulation</topic><topic>Biochemical, Molecular, and Genetic Mechanisms</topic><topic>Blood</topic><topic>Child Development - drug effects</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Diet</topic><topic>Environmental Health and Occupational Health</topic><topic>Exposure</topic><topic>Fatty acids</topic><topic>Fatty Acids, Unsaturated - administration & dosage</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Fish</topic><topic>Fish consumption</topic><topic>Fishes</topic><topic>Food Contamination - analysis</topic><topic>Gestation</topic><topic>Hair</topic><topic>Hair - chemistry</topic><topic>Health Sciences</topic><topic>Humans</topic><topic>Hälsovetenskap</topic><topic>Leukocytes</topic><topic>Leukocytes - drug effects</topic><topic>Linear Models</topic><topic>Maternal infant nutrition</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Mercury</topic><topic>Mercury (metal)</topic><topic>Methylmercury</topic><topic>Methylmercury Compounds - analysis</topic><topic>Methylmercury exposure</topic><topic>Mothers</topic><topic>Nutrition</topic><topic>Polymerase chain reaction</topic><topic>Polyunsaturated fatty acid status</topic><topic>Polyunsaturated fatty acids</topic><topic>Pregnancy</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Seafood - analysis</topic><topic>Seychelles</topic><topic>Seychelles Child Development Study</topic><topic>Socioeconomics</topic><topic>Telomere - drug effects</topic><topic>Telomere - ultrastructure</topic><topic>Telomere length</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeates, Alison J</creatorcontrib><creatorcontrib>Thurston, Sally W</creatorcontrib><creatorcontrib>Li, Huiqi</creatorcontrib><creatorcontrib>Mulhern, Maria S</creatorcontrib><creatorcontrib>McSorley, Emeir M</creatorcontrib><creatorcontrib>Watson, Gene E</creatorcontrib><creatorcontrib>Shamlaye, Conrad F</creatorcontrib><creatorcontrib>Strain, JJ</creatorcontrib><creatorcontrib>Myers, Gary J</creatorcontrib><creatorcontrib>Davidson, Philip W</creatorcontrib><creatorcontrib>van Wijngaarden, Edwin</creatorcontrib><creatorcontrib>Broberg, Karin</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeates, Alison J</au><au>Thurston, Sally W</au><au>Li, Huiqi</au><au>Mulhern, Maria S</au><au>McSorley, Emeir M</au><au>Watson, Gene E</au><au>Shamlaye, Conrad F</au><au>Strain, JJ</au><au>Myers, Gary J</au><au>Davidson, Philip W</au><au>van Wijngaarden, Edwin</au><au>Broberg, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>147</volume><issue>11</issue><spage>2018</spage><epage>2024</epage><pages>2018-2024</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.
The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high.
Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatal mercury was also measured in children's hair samples with the use of a cumulative metric derived from values obtained at 3–5 y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL.
Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n–6:n–3 PUFA ratio was significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status and methylmercury exposure were not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of age were significantly associated with longer TLs in cord blood (β = 0.005, P = 0.03).
We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28978678</pmid><doi>10.3945/jn.117.253021</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3397-1116</orcidid><orcidid>https://orcid.org/0000-0003-4317-015X</orcidid><orcidid>https://orcid.org/0000-0002-2393-1663</orcidid><orcidid>https://orcid.org/0000-0002-5862-468X</orcidid><orcidid>https://orcid.org/0000-0003-1861-3991</orcidid><orcidid>https://orcid.org/0000-0002-2212-3744</orcidid><orcidid>https://orcid.org/0000-0002-1127-0829</orcidid><orcidid>https://orcid.org/0000-0002-1633-2873</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 2017-11, Vol.147 (11), p.2018-2024 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_493594 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adolescent Adult Age related diseases Animals Arbetsmedicin och miljömedicin Bioaccumulation Biochemical, Molecular, and Genetic Mechanisms Blood Child Development - drug effects Child, Preschool Children & youth Cohort Studies Diet Environmental Health and Occupational Health Exposure Fatty acids Fatty Acids, Unsaturated - administration & dosage Fatty Acids, Unsaturated - blood Fish Fish consumption Fishes Food Contamination - analysis Gestation Hair Hair - chemistry Health Sciences Humans Hälsovetenskap Leukocytes Leukocytes - drug effects Linear Models Maternal infant nutrition Medical and Health Sciences Medicin och hälsovetenskap Mercury Mercury (metal) Methylmercury Methylmercury Compounds - analysis Methylmercury exposure Mothers Nutrition Polymerase chain reaction Polyunsaturated fatty acid status Polyunsaturated fatty acids Pregnancy Regression analysis Regression models Seafood - analysis Seychelles Seychelles Child Development Study Socioeconomics Telomere - drug effects Telomere - ultrastructure Telomere length Young Adult |
| title | PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T04%3A55%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PUFA%20Status%20and%20Methylmercury%20Exposure%20Are%20Not%20Associated%20with%20Leukocyte%20Telomere%20Length%20in%20Mothers%20or%20Their%20Children%20in%20the%20Seychelles%20Child%20Development%20Study&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=Yeates,%20Alison%20J&rft.date=2017-11-01&rft.volume=147&rft.issue=11&rft.spage=2018&rft.epage=2024&rft.pages=2018-2024&rft.issn=0022-3166&rft.eissn=1541-6100&rft_id=info:doi/10.3945/jn.117.253021&rft_dat=%3Cproquest_swepu%3E1982170447%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1982170447&rft_id=info:pmid/28978678&rft_els_id=S0022316622106152&rfr_iscdi=true |