Animal models to explore the effects of glucocorticoids on skeletal growth and structure

Glucocorticoids (GCs) are effective for the treatment of many chronic conditions, but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear,...

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Veröffentlicht in:	Journal of endocrinology 2018-01, Vol.236 (1), p.R69-R91
Hauptverfasser:	Wood, Claire L, Soucek, Ondrej, Wong, Sze C, Zaman, Farasat, Farquharson, Colin, Savendahl, Lars, Ahmed, S Faisal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Genetically Modified Bone Development - drug effects Chronic illnesses Disease Models, Animal Glucocorticoids Glucocorticoids - adverse effects Growth Disorders - chemically induced Growth rate Humans Osteoclasts - drug effects Osteocytes - drug effects Osteoporosis Osteoporosis - chemically induced Review Skeleton - growth & development Studies
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