Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data
Objectives To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large popu...
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| Veröffentlicht in: | European radiology 2018-04, Vol.28 (4), p.1739-1747 |
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| container_title | European radiology |
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| creator | Velickaite, V. Ferreira, D. Cavallin, L. Lind, L. Ahlström, H. Kilander, L. Westman, E. Larsson, E.-M. |
| description | Objectives
To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.
Methods
Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens’s scale was used to assess visually MTA scores (0–4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.
Results
Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.
Conclusion
At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.
Key Points
•
Gender and education are confounders for MTA grading.
•
We suggest cut-off values for 75-year-olds, taking gender and education into account.
•
Males have higher MTA scores than women.
•
Higher MTA scores are associated with worse cognitive performance. |
| doi_str_mv | 10.1007/s00330-017-5103-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_492689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1963278686</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-1c4b0c3f0f292f6b40ff1a69c3e29af64de22efc12ade399e4cc6ab18e2e946a3</originalsourceid><addsrcrecordid>eNp1kstu1TAQhiMEoqeFB2CDLLFhUYNvsWMWSFW5SkVsgK3lOJOclMRO7aTovAMPjY9yaClSVx7NfPOPPf6L4hklrygh6nUihHOCCVW4pIRj-aDYUMEZpqQSD4sN0bzCSmtxVByndEkI0VSox8UR05QJXvFN8fsLNL0d0AzjFGIOhlADsnMM03aHop173yXUe2TRYGMHSJV4BzbiMDRoCtMyZCR4XNsEDXJhG-L8BnXgG4jYhRjBzblgfYOgWdwK3-Z9iGPOXQNq7GyfFI9aOyR4ejhPiu8f3n87_4Qvvn78fH52gV2p-YypEzVxvCUt06yVtSBtS63UjgPTtpWiAcagdZTZBrjWIJyTtqYVMNBCWn5S4FU3_YJpqc0U-9HGnQm2N4fUzxyBEZrJSmf-9F7-Xf_jzITYmWUxnHOlRMbfrnhmR2gc-Dlv9k7X3Yrvt6YL16asuChLlQVeHgRiuFogzWbsk4NhsB7CkgzVkjNVyUpm9MV_6GVYos_bMyx_d0WVKmmm6Eq5GFKK0N5chhKzt5JZrWSylczeSmav_PzfV9x0_PVOBthhK7nkO4i3o-9X_QO5h9iR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2009817751</pqid></control><display><type>article</type><title>Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>SWEPUB Freely available online</source><creator>Velickaite, V. ; Ferreira, D. ; Cavallin, L. ; Lind, L. ; Ahlström, H. ; Kilander, L. ; Westman, E. ; Larsson, E.-M.</creator><creatorcontrib>Velickaite, V. ; Ferreira, D. ; Cavallin, L. ; Lind, L. ; Ahlström, H. ; Kilander, L. ; Westman, E. ; Larsson, E.-M.</creatorcontrib><description>Objectives
To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.
Methods
Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens’s scale was used to assess visually MTA scores (0–4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.
Results
Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.
Conclusion
At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.
Key Points
•
Gender and education are confounders for MTA grading.
•
We suggest cut-off values for 75-year-olds, taking gender and education into account.
•
Males have higher MTA scores than women.
•
Higher MTA scores are associated with worse cognitive performance.</description><identifier>ISSN: 0938-7994</identifier><identifier>ISSN: 1432-1084</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-017-5103-6</identifier><identifier>PMID: 29124383</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Aging - pathology ; Aging - psychology ; Atrophy ; Atrophy - diagnostic imaging ; Brain ; Cognition ; Cognitive ability ; Cognitive tasks ; Cognitive test ; Cohort Studies ; Confounding Factors, Epidemiologic ; Dementia ; Dementia - pathology ; Diagnostic Radiology ; Education ; Educational Status ; Evaluation ; Female ; Gender ; Grading ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Longitudinal analysis ; Magnetic Resonance Imaging ; Male ; Males ; Medial temporal lobe atrophy (MTA) ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuro ; Neuroimaging ; Neuroradiology ; Population-based ; Radiology ; Reference Values ; Scheltens’s scale ; Sex Factors ; Temporal lobe ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - pathology ; Ultrasound</subject><ispartof>European radiology, 2018-04, Vol.28 (4), p.1739-1747</ispartof><rights>The Author(s) 2017</rights><rights>European Radiology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-1c4b0c3f0f292f6b40ff1a69c3e29af64de22efc12ade399e4cc6ab18e2e946a3</citedby><cites>FETCH-LOGICAL-c593t-1c4b0c3f0f292f6b40ff1a69c3e29af64de22efc12ade399e4cc6ab18e2e946a3</cites><orcidid>0000-0001-7270-075X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-017-5103-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-017-5103-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29124383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333774$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137789517$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Velickaite, V.</creatorcontrib><creatorcontrib>Ferreira, D.</creatorcontrib><creatorcontrib>Cavallin, L.</creatorcontrib><creatorcontrib>Lind, L.</creatorcontrib><creatorcontrib>Ahlström, H.</creatorcontrib><creatorcontrib>Kilander, L.</creatorcontrib><creatorcontrib>Westman, E.</creatorcontrib><creatorcontrib>Larsson, E.-M.</creatorcontrib><title>Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.
Methods
Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens’s scale was used to assess visually MTA scores (0–4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.
Results
Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.
Conclusion
At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.
Key Points
•
Gender and education are confounders for MTA grading.
•
We suggest cut-off values for 75-year-olds, taking gender and education into account.
•
Males have higher MTA scores than women.
•
Higher MTA scores are associated with worse cognitive performance.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Aging - psychology</subject><subject>Atrophy</subject><subject>Atrophy - diagnostic imaging</subject><subject>Brain</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive tasks</subject><subject>Cognitive test</subject><subject>Cohort Studies</subject><subject>Confounding Factors, Epidemiologic</subject><subject>Dementia</subject><subject>Dementia - pathology</subject><subject>Diagnostic Radiology</subject><subject>Education</subject><subject>Educational Status</subject><subject>Evaluation</subject><subject>Female</subject><subject>Gender</subject><subject>Grading</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Longitudinal analysis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Medial temporal lobe atrophy (MTA)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuro</subject><subject>Neuroimaging</subject><subject>Neuroradiology</subject><subject>Population-based</subject><subject>Radiology</subject><subject>Reference Values</subject><subject>Scheltens’s scale</subject><subject>Sex Factors</subject><subject>Temporal lobe</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - pathology</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNp1kstu1TAQhiMEoqeFB2CDLLFhUYNvsWMWSFW5SkVsgK3lOJOclMRO7aTovAMPjY9yaClSVx7NfPOPPf6L4hklrygh6nUihHOCCVW4pIRj-aDYUMEZpqQSD4sN0bzCSmtxVByndEkI0VSox8UR05QJXvFN8fsLNL0d0AzjFGIOhlADsnMM03aHop173yXUe2TRYGMHSJV4BzbiMDRoCtMyZCR4XNsEDXJhG-L8BnXgG4jYhRjBzblgfYOgWdwK3-Z9iGPOXQNq7GyfFI9aOyR4ejhPiu8f3n87_4Qvvn78fH52gV2p-YypEzVxvCUt06yVtSBtS63UjgPTtpWiAcagdZTZBrjWIJyTtqYVMNBCWn5S4FU3_YJpqc0U-9HGnQm2N4fUzxyBEZrJSmf-9F7-Xf_jzITYmWUxnHOlRMbfrnhmR2gc-Dlv9k7X3Yrvt6YL16asuChLlQVeHgRiuFogzWbsk4NhsB7CkgzVkjNVyUpm9MV_6GVYos_bMyx_d0WVKmmm6Eq5GFKK0N5chhKzt5JZrWSylczeSmav_PzfV9x0_PVOBthhK7nkO4i3o-9X_QO5h9iR</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Velickaite, V.</creator><creator>Ferreira, D.</creator><creator>Cavallin, L.</creator><creator>Lind, L.</creator><creator>Ahlström, H.</creator><creator>Kilander, L.</creator><creator>Westman, E.</creator><creator>Larsson, E.-M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-7270-075X</orcidid></search><sort><creationdate>20180401</creationdate><title>Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data</title><author>Velickaite, V. ; Ferreira, D. ; Cavallin, L. ; Lind, L. ; Ahlström, H. ; Kilander, L. ; Westman, E. ; Larsson, E.-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-1c4b0c3f0f292f6b40ff1a69c3e29af64de22efc12ade399e4cc6ab18e2e946a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Aging - psychology</topic><topic>Atrophy</topic><topic>Atrophy - diagnostic imaging</topic><topic>Brain</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive tasks</topic><topic>Cognitive test</topic><topic>Cohort Studies</topic><topic>Confounding Factors, Epidemiologic</topic><topic>Dementia</topic><topic>Dementia - pathology</topic><topic>Diagnostic Radiology</topic><topic>Education</topic><topic>Educational Status</topic><topic>Evaluation</topic><topic>Female</topic><topic>Gender</topic><topic>Grading</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Longitudinal analysis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Males</topic><topic>Medial temporal lobe atrophy (MTA)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuro</topic><topic>Neuroimaging</topic><topic>Neuroradiology</topic><topic>Population-based</topic><topic>Radiology</topic><topic>Reference Values</topic><topic>Scheltens’s scale</topic><topic>Sex Factors</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - pathology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velickaite, V.</creatorcontrib><creatorcontrib>Ferreira, D.</creatorcontrib><creatorcontrib>Cavallin, L.</creatorcontrib><creatorcontrib>Lind, L.</creatorcontrib><creatorcontrib>Ahlström, H.</creatorcontrib><creatorcontrib>Kilander, L.</creatorcontrib><creatorcontrib>Westman, E.</creatorcontrib><creatorcontrib>Larsson, E.-M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velickaite, V.</au><au>Ferreira, D.</au><au>Cavallin, L.</au><au>Lind, L.</au><au>Ahlström, H.</au><au>Kilander, L.</au><au>Westman, E.</au><au>Larsson, E.-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>28</volume><issue>4</issue><spage>1739</spage><epage>1747</epage><pages>1739-1747</pages><issn>0938-7994</issn><issn>1432-1084</issn><eissn>1432-1084</eissn><abstract>Objectives
To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.
Methods
Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens’s scale was used to assess visually MTA scores (0–4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.
Results
Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.
Conclusion
At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.
Key Points
•
Gender and education are confounders for MTA grading.
•
We suggest cut-off values for 75-year-olds, taking gender and education into account.
•
Males have higher MTA scores than women.
•
Higher MTA scores are associated with worse cognitive performance.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29124383</pmid><doi>10.1007/s00330-017-5103-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7270-075X</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0938-7994 1432-1084 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; SWEPUB Freely available online |
| subjects | Aged Aged, 80 and over Aging - pathology Aging - psychology Atrophy Atrophy - diagnostic imaging Brain Cognition Cognitive ability Cognitive tasks Cognitive test Cohort Studies Confounding Factors, Epidemiologic Dementia Dementia - pathology Diagnostic Radiology Education Educational Status Evaluation Female Gender Grading Humans Imaging Internal Medicine Interventional Radiology Longitudinal analysis Magnetic Resonance Imaging Male Males Medial temporal lobe atrophy (MTA) Medicine Medicine & Public Health Middle Aged Neuro Neuroimaging Neuroradiology Population-based Radiology Reference Values Scheltens’s scale Sex Factors Temporal lobe Temporal Lobe - diagnostic imaging Temporal Lobe - pathology Ultrasound |
| title | Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data |
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