Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth
Objective Systemic lupus erythematosus (SLE) and asthma share inheritable IgE‐related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and...
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| Veröffentlicht in: | Arthritis care & research (2010) 2018-08, Vol.70 (8), p.1269-1274 |
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| creator | Rossides, Marios Nguyen, Cathina Arkema, Elizabeth V. Simard, Julia F. |
| description | Objective
Systemic lupus erythematosus (SLE) and asthma share inheritable IgE‐related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and examine the role of preterm birth as a mediator of the association using Swedish register data.
Methods
Information on 12,000 singleton live births (2001–2013) was collected from the Medical Birth Register. Childhood asthma was defined as at least 1 International Classification of Diseases–coded visit in the National Patient Register. Prevalent maternal SLE at delivery was identified from the Medical Birth Register and the National Patient Register. Risk ratios for asthma were estimated while controlling for confounders. Mediation analysis was used to estimate what percentage of the total effect can be explained by preterm birth (defined as either |
| doi_str_mv | 10.1002/acr.23472 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_492679</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1963274354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4812-a8ccc2acce7d039fe9c77f1e5439dfe58e9c7cb71b6a9d748f5ac7ded4221a133</originalsourceid><addsrcrecordid>eNp1kctu1DAUhi0EolXpghdAltjAIm18i-MN0nRULtIgUAHBCsvjnBCXJB5sh2rehmfhyfCQYUSR8Mbn8p1fR-dH6CEpz0hZ0nNjwxllXNI76JgSQQpeifruIeafjtBpjNdlfozWNVP30RFVhApV0mP0eRFTNxjsRrzsXN8EGLFv8WufOggRf3Spw--2McHg7M8fq2kzRXwZtrk7mORjzszY4JziK9_DbvRtgARhwBcupO4ButeaPsLp_j9BH55fvl--LFZvXrxaLlaF5TWhhamttdRYC7IpmWpBWSlbAoIz1bQg6l3BriVZV0Y1ktetMFY20HBKiSGMnaBi1o03sJnWehPcYMJWe-P0vvQ1R6C5opVUmX8287kzQGNhTMH0t8Zud0bX6S_-uxaKC8Z5FniyFwj-2wQx6cFFC31vRvBT1ERVjErOxA59_A967acw5nNoWspKMVYpkamnM2WDjzFAe1iGlHpntM5G699GZ_bR39sfyD-2ZuB8Bm5cD9v_K-nF8mqW_AWQebTT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2076933695</pqid></control><display><type>article</type><title>Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><creator>Rossides, Marios ; Nguyen, Cathina ; Arkema, Elizabeth V. ; Simard, Julia F.</creator><creatorcontrib>Rossides, Marios ; Nguyen, Cathina ; Arkema, Elizabeth V. ; Simard, Julia F.</creatorcontrib><description>Objective
Systemic lupus erythematosus (SLE) and asthma share inheritable IgE‐related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and examine the role of preterm birth as a mediator of the association using Swedish register data.
Methods
Information on 12,000 singleton live births (2001–2013) was collected from the Medical Birth Register. Childhood asthma was defined as at least 1 International Classification of Diseases–coded visit in the National Patient Register. Prevalent maternal SLE at delivery was identified from the Medical Birth Register and the National Patient Register. Risk ratios for asthma were estimated while controlling for confounders. Mediation analysis was used to estimate what percentage of the total effect can be explained by preterm birth (defined as either <34 or <37 weeks of gestation).
Results
We compared 775 children born to mothers with SLE with 11,225 born to mothers without SLE. Ninety seven children of mothers with SLE (13%) were diagnosed with asthma, compared to 1,211 in the unexposed group (11%). The risk ratio for childhood asthma was 1.46 (95% confidence interval 1.16–1.84). In mediation analysis, 20–29% of the total effect of SLE was explained by preterm birth.
Conclusion
Prevalent maternal SLE during pregnancy is associated with an increased risk of asthma in the offspring. While preterm birth can explain a fair proportion of this association, additional unidentified mechanisms also likely play a role.</description><identifier>ISSN: 2151-464X</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.23472</identifier><identifier>PMID: 29125902</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Asthma ; Asthma - epidemiology ; Asthma - etiology ; Asthma - physiopathology ; Birth ; Children ; Cohort Studies ; Female ; Gestation ; Health risk assessment ; Humans ; Immunoglobulin E ; Incidence ; Infant, Newborn ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - diagnosis ; Male ; Maternal Age ; Offspring ; Pregnancy ; Pregnancy Complications ; Pregnancy, High-Risk ; Premature Birth ; Reference Values ; Registries ; Retrospective Studies ; Risk Assessment ; Smoking - adverse effects ; Smoking - epidemiology ; Sweden - epidemiology ; Systemic lupus erythematosus</subject><ispartof>Arthritis care & research (2010), 2018-08, Vol.70 (8), p.1269-1274</ispartof><rights>2017, American College of Rheumatology</rights><rights>2017, American College of Rheumatology.</rights><rights>2018 American College of Rheumatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4812-a8ccc2acce7d039fe9c77f1e5439dfe58e9c7cb71b6a9d748f5ac7ded4221a133</citedby><cites>FETCH-LOGICAL-c4812-a8ccc2acce7d039fe9c77f1e5439dfe58e9c7cb71b6a9d748f5ac7ded4221a133</cites><orcidid>0000-0002-9769-324X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.23472$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.23472$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29125902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:139209335$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rossides, Marios</creatorcontrib><creatorcontrib>Nguyen, Cathina</creatorcontrib><creatorcontrib>Arkema, Elizabeth V.</creatorcontrib><creatorcontrib>Simard, Julia F.</creatorcontrib><title>Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description>Objective
Systemic lupus erythematosus (SLE) and asthma share inheritable IgE‐related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and examine the role of preterm birth as a mediator of the association using Swedish register data.
Methods
Information on 12,000 singleton live births (2001–2013) was collected from the Medical Birth Register. Childhood asthma was defined as at least 1 International Classification of Diseases–coded visit in the National Patient Register. Prevalent maternal SLE at delivery was identified from the Medical Birth Register and the National Patient Register. Risk ratios for asthma were estimated while controlling for confounders. Mediation analysis was used to estimate what percentage of the total effect can be explained by preterm birth (defined as either <34 or <37 weeks of gestation).
Results
We compared 775 children born to mothers with SLE with 11,225 born to mothers without SLE. Ninety seven children of mothers with SLE (13%) were diagnosed with asthma, compared to 1,211 in the unexposed group (11%). The risk ratio for childhood asthma was 1.46 (95% confidence interval 1.16–1.84). In mediation analysis, 20–29% of the total effect of SLE was explained by preterm birth.
Conclusion
Prevalent maternal SLE during pregnancy is associated with an increased risk of asthma in the offspring. While preterm birth can explain a fair proportion of this association, additional unidentified mechanisms also likely play a role.</description><subject>Adult</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Asthma - physiopathology</subject><subject>Birth</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gestation</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy, High-Risk</subject><subject>Premature Birth</subject><subject>Reference Values</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Sweden - epidemiology</subject><subject>Systemic lupus erythematosus</subject><issn>2151-464X</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kctu1DAUhi0EolXpghdAltjAIm18i-MN0nRULtIgUAHBCsvjnBCXJB5sh2rehmfhyfCQYUSR8Mbn8p1fR-dH6CEpz0hZ0nNjwxllXNI76JgSQQpeifruIeafjtBpjNdlfozWNVP30RFVhApV0mP0eRFTNxjsRrzsXN8EGLFv8WufOggRf3Spw--2McHg7M8fq2kzRXwZtrk7mORjzszY4JziK9_DbvRtgARhwBcupO4ButeaPsLp_j9BH55fvl--LFZvXrxaLlaF5TWhhamttdRYC7IpmWpBWSlbAoIz1bQg6l3BriVZV0Y1ktetMFY20HBKiSGMnaBi1o03sJnWehPcYMJWe-P0vvQ1R6C5opVUmX8287kzQGNhTMH0t8Zud0bX6S_-uxaKC8Z5FniyFwj-2wQx6cFFC31vRvBT1ERVjErOxA59_A967acw5nNoWspKMVYpkamnM2WDjzFAe1iGlHpntM5G699GZ_bR39sfyD-2ZuB8Bm5cD9v_K-nF8mqW_AWQebTT</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Rossides, Marios</creator><creator>Nguyen, Cathina</creator><creator>Arkema, Elizabeth V.</creator><creator>Simard, Julia F.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-9769-324X</orcidid></search><sort><creationdate>201808</creationdate><title>Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth</title><author>Rossides, Marios ; Nguyen, Cathina ; Arkema, Elizabeth V. ; Simard, Julia F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4812-a8ccc2acce7d039fe9c77f1e5439dfe58e9c7cb71b6a9d748f5ac7ded4221a133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Asthma - physiopathology</topic><topic>Birth</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Gestation</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy, High-Risk</topic><topic>Premature Birth</topic><topic>Reference Values</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Sweden - epidemiology</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossides, Marios</creatorcontrib><creatorcontrib>Nguyen, Cathina</creatorcontrib><creatorcontrib>Arkema, Elizabeth V.</creatorcontrib><creatorcontrib>Simard, Julia F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rossides, Marios</au><au>Nguyen, Cathina</au><au>Arkema, Elizabeth V.</au><au>Simard, Julia F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2018-08</date><risdate>2018</risdate><volume>70</volume><issue>8</issue><spage>1269</spage><epage>1274</epage><pages>1269-1274</pages><issn>2151-464X</issn><eissn>2151-4658</eissn><abstract>Objective
Systemic lupus erythematosus (SLE) and asthma share inheritable IgE‐related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and examine the role of preterm birth as a mediator of the association using Swedish register data.
Methods
Information on 12,000 singleton live births (2001–2013) was collected from the Medical Birth Register. Childhood asthma was defined as at least 1 International Classification of Diseases–coded visit in the National Patient Register. Prevalent maternal SLE at delivery was identified from the Medical Birth Register and the National Patient Register. Risk ratios for asthma were estimated while controlling for confounders. Mediation analysis was used to estimate what percentage of the total effect can be explained by preterm birth (defined as either <34 or <37 weeks of gestation).
Results
We compared 775 children born to mothers with SLE with 11,225 born to mothers without SLE. Ninety seven children of mothers with SLE (13%) were diagnosed with asthma, compared to 1,211 in the unexposed group (11%). The risk ratio for childhood asthma was 1.46 (95% confidence interval 1.16–1.84). In mediation analysis, 20–29% of the total effect of SLE was explained by preterm birth.
Conclusion
Prevalent maternal SLE during pregnancy is associated with an increased risk of asthma in the offspring. While preterm birth can explain a fair proportion of this association, additional unidentified mechanisms also likely play a role.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29125902</pmid><doi>10.1002/acr.23472</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9769-324X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Adult Asthma Asthma - epidemiology Asthma - etiology Asthma - physiopathology Birth Children Cohort Studies Female Gestation Health risk assessment Humans Immunoglobulin E Incidence Infant, Newborn Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - diagnosis Male Maternal Age Offspring Pregnancy Pregnancy Complications Pregnancy, High-Risk Premature Birth Reference Values Registries Retrospective Studies Risk Assessment Smoking - adverse effects Smoking - epidemiology Sweden - epidemiology Systemic lupus erythematosus |
| title | Asthma in Children of Mothers With Systemic Lupus Erythematosus and the Role of Preterm Birth |
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