Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial
Purpose Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to c...
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| Veröffentlicht in: | Breast cancer research and treatment 2018-02, Vol.168 (1), p.79-93 |
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| creator | Mijwel, Sara Backman, Malin Bolam, Kate A. Jervaeus, Anna Sundberg, Carl Johan Margolin, Sara Browall, Maria Rundqvist, Helene Wengström, Yvonne |
| description | Purpose
Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT–HIIT), and moderate-intensity aerobic and high-intensity interval training (AT–HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.
Methods
Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT–HIIT, AT–HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.
Results
The RT–HIIT group was superior to UC for CRF: total CRF (
p
= 0.02), behavior/daily life (
p
= 0.01), and sensory/physical (
p
= 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT–HIIT compared to declines shown in the UC group (
p
= 0.04). AT–HIIT significantly improved emotional functioning versus UC (
p
= 0.01) and was superior to UC for pain symptoms (
p
= 0.03). RT–HIIT reported a reduced symptom burden, while AT–HIIT remained stable compared to deteriorations shown by UC (
p
|
| doi_str_mv | 10.1007/s10549-017-4571-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_492590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A538249175</galeid><sourcerecordid>A538249175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c745t-244b78d5e350ccabc613818f875ff35154aa5f6d11dd06cc900a3e4c13d0dbd23</originalsourceid><addsrcrecordid>eNqNk91qFDEUxwdRbK0-gDcSEETQqckkmUx6ISz1Ewq9qd6GbJLZyZqZbJPMyvp0PpqZ7lp3xYLMxRxyfud_kvNRFE8RPEUQsjcRQUp4CRErCWWoxPeKY0QZLlmF2P3iGKKalXUD66PiUYxLCCFnkD8sjiqOMM8Kx8XPmdZ2WIDOLrrSDskM0aYNmKywlg6kIO0wAckD5Ye1GZL1w76j91o6m6yJZ8Cvku3tjxtBI13qymCcTEYDPyblexOBHsPkVp3pfepMkKsNaH0A82BkTEDJQZlwBrILXGa1qykNCHLQPgtnoXyJFLxz2UzBSve4eNBKF82T3f-k-PLh_dX5p_Li8uPn89lFqRihqawImbNGU4MpVErOVY1wg5q2YbRtMUWUSEnbWiOkNayVytWR2BCFsIZ6rit8UpRb3fjdrMa5WAXby7ARXlqxO_qWLSMIryiHmX91J__Ofp0JHxaiWwrMq4pk-vV_0DYKRHjTZPztFs9sb7TKXQnSHUQdegbbiYVfC9oQBjHOAi93AsFfjyYm0duojHNyMH7MaXhNas4qPl3t-V_o0o8hj8ANhRmrUUX_UAvpjLBD63NeNYmKGcVNRThiE3X6Dyp_2vQ2d9a0Np8fBLzYC9jOVPRunIYwHoJoC6rgYwymvS0GgmJaFrFdFpGXRUzLIqYiPNuv4m3E7-3IQLXrymoaWhP2nn6n6i81GSVa</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963776125</pqid></control><display><type>article</type><title>Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>SWEPUB Freely available online</source><creator>Mijwel, Sara ; Backman, Malin ; Bolam, Kate A. ; Jervaeus, Anna ; Sundberg, Carl Johan ; Margolin, Sara ; Browall, Maria ; Rundqvist, Helene ; Wengström, Yvonne</creator><creatorcontrib>Mijwel, Sara ; Backman, Malin ; Bolam, Kate A. ; Jervaeus, Anna ; Sundberg, Carl Johan ; Margolin, Sara ; Browall, Maria ; Rundqvist, Helene ; Wengström, Yvonne</creatorcontrib><description>Purpose
Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT–HIIT), and moderate-intensity aerobic and high-intensity interval training (AT–HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.
Methods
Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT–HIIT, AT–HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.
Results
The RT–HIIT group was superior to UC for CRF: total CRF (
p
= 0.02), behavior/daily life (
p
= 0.01), and sensory/physical (
p
= 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT–HIIT compared to declines shown in the UC group (
p
= 0.04). AT–HIIT significantly improved emotional functioning versus UC (
p
= 0.01) and was superior to UC for pain symptoms (
p
= 0.03). RT–HIIT reported a reduced symptom burden, while AT–HIIT remained stable compared to deteriorations shown by UC (
p
< 0.01). Only RT–HIIT was superior to UC for total symptoms (
p
< 0.01).
Conclusions
16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.
Trial registration
Clinicaltrials.gov Registration Number: NCT02522260.</description><identifier>ISSN: 0167-6806</identifier><identifier>ISSN: 1573-7217</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-017-4571-3</identifier><identifier>PMID: 29139007</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Antineoplastic Agents - adverse effects ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - rehabilitation ; Cancer research ; Chemotherapy ; Clinical Trial ; Clinical trials ; Cognitive ability ; Concurrent training ; Exercise ; Exercise therapy ; Exercise Therapy - methods ; Fatigue ; Fatigue - diagnosis ; Fatigue - epidemiology ; Fatigue - etiology ; Fatigue - rehabilitation ; Female ; Health-related quality of life ; High-Intensity Interval Training ; Humans ; Medical schools ; Medicine ; Medicine & Public Health ; Middle Aged ; NCT ; NCT02522260 ; Oncology ; Pain ; Physical Fitness ; Quality of Life ; Rehabilitation ; Symptom burden ; Treatment Outcome ; Välbefinnande vid långvariga hälsoproblem (WeLHP) ; Wellbeing in long-term health problems (WeLHP)</subject><ispartof>Breast cancer research and treatment, 2018-02, Vol.168 (1), p.79-93</ispartof><rights>The Author(s) 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Breast Cancer Research and Treatment is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c745t-244b78d5e350ccabc613818f875ff35154aa5f6d11dd06cc900a3e4c13d0dbd23</citedby><cites>FETCH-LOGICAL-c745t-244b78d5e350ccabc613818f875ff35154aa5f6d11dd06cc900a3e4c13d0dbd23</cites><orcidid>0000-0002-6718-5797</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-017-4571-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-017-4571-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29139007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14988$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39224$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137784390$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Mijwel, Sara</creatorcontrib><creatorcontrib>Backman, Malin</creatorcontrib><creatorcontrib>Bolam, Kate A.</creatorcontrib><creatorcontrib>Jervaeus, Anna</creatorcontrib><creatorcontrib>Sundberg, Carl Johan</creatorcontrib><creatorcontrib>Margolin, Sara</creatorcontrib><creatorcontrib>Browall, Maria</creatorcontrib><creatorcontrib>Rundqvist, Helene</creatorcontrib><creatorcontrib>Wengström, Yvonne</creatorcontrib><title>Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT–HIIT), and moderate-intensity aerobic and high-intensity interval training (AT–HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.
Methods
Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT–HIIT, AT–HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.
Results
The RT–HIIT group was superior to UC for CRF: total CRF (
p
= 0.02), behavior/daily life (
p
= 0.01), and sensory/physical (
p
= 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT–HIIT compared to declines shown in the UC group (
p
= 0.04). AT–HIIT significantly improved emotional functioning versus UC (
p
= 0.01) and was superior to UC for pain symptoms (
p
= 0.03). RT–HIIT reported a reduced symptom burden, while AT–HIIT remained stable compared to deteriorations shown by UC (
p
< 0.01). Only RT–HIIT was superior to UC for total symptoms (
p
< 0.01).
Conclusions
16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.
Trial registration
Clinicaltrials.gov Registration Number: NCT02522260.</description><subject>Adult</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - rehabilitation</subject><subject>Cancer research</subject><subject>Chemotherapy</subject><subject>Clinical Trial</subject><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>Concurrent training</subject><subject>Exercise</subject><subject>Exercise therapy</subject><subject>Exercise Therapy - methods</subject><subject>Fatigue</subject><subject>Fatigue - diagnosis</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - etiology</subject><subject>Fatigue - rehabilitation</subject><subject>Female</subject><subject>Health-related quality of life</subject><subject>High-Intensity Interval Training</subject><subject>Humans</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>NCT</subject><subject>NCT02522260</subject><subject>Oncology</subject><subject>Pain</subject><subject>Physical Fitness</subject><subject>Quality of Life</subject><subject>Rehabilitation</subject><subject>Symptom burden</subject><subject>Treatment Outcome</subject><subject>Välbefinnande vid långvariga hälsoproblem (WeLHP)</subject><subject>Wellbeing in long-term health problems (WeLHP)</subject><issn>0167-6806</issn><issn>1573-7217</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNqNk91qFDEUxwdRbK0-gDcSEETQqckkmUx6ISz1Ewq9qd6GbJLZyZqZbJPMyvp0PpqZ7lp3xYLMxRxyfud_kvNRFE8RPEUQsjcRQUp4CRErCWWoxPeKY0QZLlmF2P3iGKKalXUD66PiUYxLCCFnkD8sjiqOMM8Kx8XPmdZ2WIDOLrrSDskM0aYNmKywlg6kIO0wAckD5Ye1GZL1w76j91o6m6yJZ8Cvku3tjxtBI13qymCcTEYDPyblexOBHsPkVp3pfepMkKsNaH0A82BkTEDJQZlwBrILXGa1qykNCHLQPgtnoXyJFLxz2UzBSve4eNBKF82T3f-k-PLh_dX5p_Li8uPn89lFqRihqawImbNGU4MpVErOVY1wg5q2YbRtMUWUSEnbWiOkNayVytWR2BCFsIZ6rit8UpRb3fjdrMa5WAXby7ARXlqxO_qWLSMIryiHmX91J__Ofp0JHxaiWwrMq4pk-vV_0DYKRHjTZPztFs9sb7TKXQnSHUQdegbbiYVfC9oQBjHOAi93AsFfjyYm0duojHNyMH7MaXhNas4qPl3t-V_o0o8hj8ANhRmrUUX_UAvpjLBD63NeNYmKGcVNRThiE3X6Dyp_2vQ2d9a0Np8fBLzYC9jOVPRunIYwHoJoC6rgYwymvS0GgmJaFrFdFpGXRUzLIqYiPNuv4m3E7-3IQLXrymoaWhP2nn6n6i81GSVa</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Mijwel, Sara</creator><creator>Backman, Malin</creator><creator>Bolam, Kate A.</creator><creator>Jervaeus, Anna</creator><creator>Sundberg, Carl Johan</creator><creator>Margolin, Sara</creator><creator>Browall, Maria</creator><creator>Rundqvist, Helene</creator><creator>Wengström, Yvonne</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ABSHZ</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF6</scope><scope>ZZAVC</scope><scope>AABRY</scope><scope>D8X</scope><orcidid>https://orcid.org/0000-0002-6718-5797</orcidid></search><sort><creationdate>20180201</creationdate><title>Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial</title><author>Mijwel, Sara ; Backman, Malin ; Bolam, Kate A. ; Jervaeus, Anna ; Sundberg, Carl Johan ; Margolin, Sara ; Browall, Maria ; Rundqvist, Helene ; Wengström, Yvonne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c745t-244b78d5e350ccabc613818f875ff35154aa5f6d11dd06cc900a3e4c13d0dbd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - rehabilitation</topic><topic>Cancer research</topic><topic>Chemotherapy</topic><topic>Clinical Trial</topic><topic>Clinical trials</topic><topic>Cognitive ability</topic><topic>Concurrent training</topic><topic>Exercise</topic><topic>Exercise therapy</topic><topic>Exercise Therapy - methods</topic><topic>Fatigue</topic><topic>Fatigue - diagnosis</topic><topic>Fatigue - epidemiology</topic><topic>Fatigue - etiology</topic><topic>Fatigue - rehabilitation</topic><topic>Female</topic><topic>Health-related quality of life</topic><topic>High-Intensity Interval Training</topic><topic>Humans</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>NCT</topic><topic>NCT02522260</topic><topic>Oncology</topic><topic>Pain</topic><topic>Physical Fitness</topic><topic>Quality of Life</topic><topic>Rehabilitation</topic><topic>Symptom burden</topic><topic>Treatment Outcome</topic><topic>Välbefinnande vid långvariga hälsoproblem (WeLHP)</topic><topic>Wellbeing in long-term health problems (WeLHP)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mijwel, Sara</creatorcontrib><creatorcontrib>Backman, Malin</creatorcontrib><creatorcontrib>Bolam, Kate A.</creatorcontrib><creatorcontrib>Jervaeus, Anna</creatorcontrib><creatorcontrib>Sundberg, Carl Johan</creatorcontrib><creatorcontrib>Margolin, Sara</creatorcontrib><creatorcontrib>Browall, Maria</creatorcontrib><creatorcontrib>Rundqvist, Helene</creatorcontrib><creatorcontrib>Wengström, Yvonne</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Högskolan i Skövde full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Högskolan i Skövde</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Högskolan i Jönköping full text</collection><collection>SWEPUB Högskolan i Jönköping</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mijwel, Sara</au><au>Backman, Malin</au><au>Bolam, Kate A.</au><au>Jervaeus, Anna</au><au>Sundberg, Carl Johan</au><au>Margolin, Sara</au><au>Browall, Maria</au><au>Rundqvist, Helene</au><au>Wengström, Yvonne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>168</volume><issue>1</issue><spage>79</spage><epage>93</epage><pages>79-93</pages><issn>0167-6806</issn><issn>1573-7217</issn><eissn>1573-7217</eissn><abstract>Purpose
Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT–HIIT), and moderate-intensity aerobic and high-intensity interval training (AT–HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.
Methods
Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT–HIIT, AT–HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.
Results
The RT–HIIT group was superior to UC for CRF: total CRF (
p
= 0.02), behavior/daily life (
p
= 0.01), and sensory/physical (
p
= 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT–HIIT compared to declines shown in the UC group (
p
= 0.04). AT–HIIT significantly improved emotional functioning versus UC (
p
= 0.01) and was superior to UC for pain symptoms (
p
= 0.03). RT–HIIT reported a reduced symptom burden, while AT–HIIT remained stable compared to deteriorations shown by UC (
p
< 0.01). Only RT–HIIT was superior to UC for total symptoms (
p
< 0.01).
Conclusions
16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.
Trial registration
Clinicaltrials.gov Registration Number: NCT02522260.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29139007</pmid><doi>10.1007/s10549-017-4571-3</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-6718-5797</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-6806 |
| ispartof | Breast cancer research and treatment, 2018-02, Vol.168 (1), p.79-93 |
| issn | 0167-6806 1573-7217 1573-7217 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_492590 |
| source | MEDLINE; SpringerLink Journals; SWEPUB Freely available online |
| subjects | Adult Antineoplastic Agents - adverse effects Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - rehabilitation Cancer research Chemotherapy Clinical Trial Clinical trials Cognitive ability Concurrent training Exercise Exercise therapy Exercise Therapy - methods Fatigue Fatigue - diagnosis Fatigue - epidemiology Fatigue - etiology Fatigue - rehabilitation Female Health-related quality of life High-Intensity Interval Training Humans Medical schools Medicine Medicine & Public Health Middle Aged NCT NCT02522260 Oncology Pain Physical Fitness Quality of Life Rehabilitation Symptom burden Treatment Outcome Välbefinnande vid långvariga hälsoproblem (WeLHP) Wellbeing in long-term health problems (WeLHP) |
| title | Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T20%3A28%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adding%20high-intensity%20interval%20training%20to%20conventional%20training%20modalities:%20optimizing%20health-related%20outcomes%20during%20chemotherapy%20for%20breast%20cancer:%20the%20OptiTrain%20randomized%20controlled%20trial&rft.jtitle=Breast%20cancer%20research%20and%20treatment&rft.au=Mijwel,%20Sara&rft.date=2018-02-01&rft.volume=168&rft.issue=1&rft.spage=79&rft.epage=93&rft.pages=79-93&rft.issn=0167-6806&rft.eissn=1573-7217&rft_id=info:doi/10.1007/s10549-017-4571-3&rft_dat=%3Cgale_swepu%3EA538249175%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1963776125&rft_id=info:pmid/29139007&rft_galeid=A538249175&rfr_iscdi=true |