Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening

Alzheimer disease and related dementias are major challenges, demanding urgent needs for earliest possible diagnosis to optimize the success rate in finding effective therapeutic interventions. Mounting solid scientific premises point at the core acetylcholine-biosynthesizing cholinergic enzyme, ChA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16287-17, Article 16287
Hauptverfasser:	Kumar, Rajnish, Kumar, Amit, Långström, Bengt, Darreh-Shori, Taher
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 59/78 631/114/2248 631/154/309/2420 631/154/53/2421 82 82/80 82/83 Acetylcholinesterase Acetylcholinesterase - metabolism Acetyltransferase Alzheimer's disease Animals Blood-Brain Barrier - metabolism Choline Choline O-acetyltransferase Choline O-Acetyltransferase - antagonists & inhibitors Dementia Down Syndrome - metabolism Humanities and Social Sciences Humans Lewy bodies Lewy Bodies - metabolism Ligands Medicin och hälsovetenskap multidisciplinary Neurodegenerative diseases Neurodegenerative Diseases - metabolism Pharmacodynamics Positron emission tomography Science Science (multidisciplinary) Therapeutic applications
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!