Long‐term cardiovascular reprogramming by short‐term perinatal exposure to nicotine's main metabolite cotinine

Aim Gather ‘proof‐of‐concept’ evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine/tobacco smoke exposure). Methods Pregnant C57 mice drank nicotine‐ or cotinine‐laced water for 6 wks from conception (NPRE = 2% saccharin + 100 μg nicotine/mL; C...

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Veröffentlicht in:	Acta Paediatrica 2018-04, Vol.107 (4), p.638-646
Hauptverfasser:	Bastianini, Stefano, Lo Martire, Viviana, Silvani, Alessandro, Zoccoli, Giovanna, Berteotti, Chiara, Lagercrantz, Hugo, Arner, Anders, Cohen, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Animals Animals, Newborn Arteries Blood pressure Blood Pressure - physiology Bradycardia Cardiovascular system Cotinine Cotinine - metabolism Disease Models, Animal Endothelium, Vascular - physiopathology Exposure Female Fetuses Heart Rate - physiology Hypotension Infants Kinases Male Maternal-Fetal Exchange - physiology Medicin och hälsovetenskap Mice mRNA Nicotine Nicotine - metabolism Perinatal exposure Perinatal reprogramming Pregnancy Protein kinase C Saccharin Sleep Smoke Tobacco Tobacco smoke Tobacco Smoke Pollution - adverse effects Vascular reactivity
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