Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS
Summary This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly...
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| creator | Svedbom, A. Borgstöm, F. Hernlund, E. Ström, O. Alekna, V. Bianchi, M. L. Clark, P. Curiel, M. D. Dimai, H. P. Jürisson, M. Kallikorm, R. Lember, M. Lesnyak, O. McCloskey, E. Sanders, K. M. Silverman, S. Solodovnikov, A. Tamulaitiene, M. Thomas, T. Toroptsova, N. Uusküla, A. Tosteson, A. N. A. Jönsson, B. Kanis, J. A. |
| description | Summary
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months.
Introduction
The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures. To date, 11 countries have participated in the study: Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, the UK, and the USA. The objective of this paper is to describe the QoL impact of hip, vertebral, and distal forearm fracture.
Methods
Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall) and at 4, 12, and 18 months after fracture. Quality of life was measured as health state utility values (HSUVs) derived from the EQ-5D-3L. Complete case analysis was conducted as the base case with available case and multiple imputation performed as sensitivity analyses. Multivariate analysis was performed to explore predictors of QoL impact of fracture.
Results
Among 5456 patients enrolled using convenience sampling, 3021 patients were eligible for the base case analysis (1415 hip, 1047 distal forearm, and 559 vertebral fractures). The mean (SD) difference between HSUV before and after fracture for hip, vertebral, and distal forearm fracture was estimated at 0.89 (0.40), 0.67 (0.45), and 0.48 (0.34), respectively (
p
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| doi_str_mv | 10.1007/s00198-017-4317-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_491959</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1976001782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-a2d32e4645864fc8d9475a5ad247ff523b7c968d1b21838d17e348bff317eac53</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi1ERbcLD8AFWeLCoQH_Sxwf0aqUSpWqApW4WU4y7qY4cbAdqpU48BA8AM_SR-mT4NUuFULiMmONf_PZMx9Czyl5TQmRbyIhVNUFobIQfBseoQUVnBdMVeVjtCCKy0IJ-vkQHcV4Q3KPUvIJOmSKcVJSukDfL2fj-rTB3mLXW8DWBzxPOHlM67tfgx_TOmJjEwTs_G0BI4TrDV730zH-BiFBE4w7xmbscNfHZNxWAEwYsA2mTXOAeP_jZ46zSzHX_IDTGvDZ6urDxcen6MAaF-HZPi_R1buTT6v3xfnF6dnq7XnRClmlwrCOMxCVKOtK2LbulJClKU3HhLS2ZLyRrarqjjaM1jxnCVzUjbV5J2Daki9RsdONtzDNjZ5CP5iw0d70el_6kk-ghaKqVJl_teOn4L_OEJMe-tiCc2YEP0dNlazy6mXNMvryH_TGz2HM02QqLzsbVNFM0R3VBh9jAPvwBUr01kq9s1JnUb21MoclerFXnpsBuoeOP95lgO2nylfjNYS_nv6v6m9wmKsf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1999701961</pqid></control><display><type>article</type><title>Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Svedbom, A. ; Borgstöm, F. ; Hernlund, E. ; Ström, O. ; Alekna, V. ; Bianchi, M. L. ; Clark, P. ; Curiel, M. D. ; Dimai, H. P. ; Jürisson, M. ; Kallikorm, R. ; Lember, M. ; Lesnyak, O. ; McCloskey, E. ; Sanders, K. M. ; Silverman, S. ; Solodovnikov, A. ; Tamulaitiene, M. ; Thomas, T. ; Toroptsova, N. ; Uusküla, A. ; Tosteson, A. N. A. ; Jönsson, B. ; Kanis, J. A.</creator><creatorcontrib>Svedbom, A. ; Borgstöm, F. ; Hernlund, E. ; Ström, O. ; Alekna, V. ; Bianchi, M. L. ; Clark, P. ; Curiel, M. D. ; Dimai, H. P. ; Jürisson, M. ; Kallikorm, R. ; Lember, M. ; Lesnyak, O. ; McCloskey, E. ; Sanders, K. M. ; Silverman, S. ; Solodovnikov, A. ; Tamulaitiene, M. ; Thomas, T. ; Toroptsova, N. ; Uusküla, A. ; Tosteson, A. N. A. ; Jönsson, B. ; Kanis, J. A.</creatorcontrib><description>Summary
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months.
Introduction
The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures. To date, 11 countries have participated in the study: Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, the UK, and the USA. The objective of this paper is to describe the QoL impact of hip, vertebral, and distal forearm fracture.
Methods
Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall) and at 4, 12, and 18 months after fracture. Quality of life was measured as health state utility values (HSUVs) derived from the EQ-5D-3L. Complete case analysis was conducted as the base case with available case and multiple imputation performed as sensitivity analyses. Multivariate analysis was performed to explore predictors of QoL impact of fracture.
Results
Among 5456 patients enrolled using convenience sampling, 3021 patients were eligible for the base case analysis (1415 hip, 1047 distal forearm, and 559 vertebral fractures). The mean (SD) difference between HSUV before and after fracture for hip, vertebral, and distal forearm fracture was estimated at 0.89 (0.40), 0.67 (0.45), and 0.48 (0.34), respectively (
p
< 0.001 for all fracture types). Eighteen months after fracture, mean HSUVs were lower than before the fracture in patients with hip fracture (0.66 vs. 0.77
p
< 0.001) and vertebral fracture (0.70 vs. 0.83
p
< 0.001). Hospitalization and higher recalled pre-fracture QoL were associated with increased QoL impact for all fracture types.
Conclusions
Hip, vertebral, and distal forearm fractures incur substantial loss in QoL and for patients with hip or vertebral fracture, QoL is markedly impaired for at least 18 months.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-017-4317-4</identifier><identifier>PMID: 29230511</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Aged ; Aged, 80 and over ; Endocrinology ; Female ; Forearm ; Forearm Injuries - rehabilitation ; Fractures ; Hip ; Hip Fractures - rehabilitation ; Hospitalization - statistics & numerical data ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Original Article ; Orthopedics ; Osteoporosis ; Osteoporotic Fractures - rehabilitation ; Psychometrics ; Quality of Life ; Recurrence ; Rheumatology ; Sensitivity analysis ; Socioeconomic Factors ; Spinal Fractures - rehabilitation ; Vertebrae</subject><ispartof>Osteoporosis international, 2018-03, Vol.29 (3), p.557-566</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2017</rights><rights>Osteoporosis International is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-a2d32e4645864fc8d9475a5ad247ff523b7c968d1b21838d17e348bff317eac53</citedby><cites>FETCH-LOGICAL-c476t-a2d32e4645864fc8d9475a5ad247ff523b7c968d1b21838d17e348bff317eac53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-017-4317-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-017-4317-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29230511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137801076$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Svedbom, A.</creatorcontrib><creatorcontrib>Borgstöm, F.</creatorcontrib><creatorcontrib>Hernlund, E.</creatorcontrib><creatorcontrib>Ström, O.</creatorcontrib><creatorcontrib>Alekna, V.</creatorcontrib><creatorcontrib>Bianchi, M. L.</creatorcontrib><creatorcontrib>Clark, P.</creatorcontrib><creatorcontrib>Curiel, M. D.</creatorcontrib><creatorcontrib>Dimai, H. P.</creatorcontrib><creatorcontrib>Jürisson, M.</creatorcontrib><creatorcontrib>Kallikorm, R.</creatorcontrib><creatorcontrib>Lember, M.</creatorcontrib><creatorcontrib>Lesnyak, O.</creatorcontrib><creatorcontrib>McCloskey, E.</creatorcontrib><creatorcontrib>Sanders, K. M.</creatorcontrib><creatorcontrib>Silverman, S.</creatorcontrib><creatorcontrib>Solodovnikov, A.</creatorcontrib><creatorcontrib>Tamulaitiene, M.</creatorcontrib><creatorcontrib>Thomas, T.</creatorcontrib><creatorcontrib>Toroptsova, N.</creatorcontrib><creatorcontrib>Uusküla, A.</creatorcontrib><creatorcontrib>Tosteson, A. N. A.</creatorcontrib><creatorcontrib>Jönsson, B.</creatorcontrib><creatorcontrib>Kanis, J. A.</creatorcontrib><title>Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months.
Introduction
The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures. To date, 11 countries have participated in the study: Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, the UK, and the USA. The objective of this paper is to describe the QoL impact of hip, vertebral, and distal forearm fracture.
Methods
Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall) and at 4, 12, and 18 months after fracture. Quality of life was measured as health state utility values (HSUVs) derived from the EQ-5D-3L. Complete case analysis was conducted as the base case with available case and multiple imputation performed as sensitivity analyses. Multivariate analysis was performed to explore predictors of QoL impact of fracture.
Results
Among 5456 patients enrolled using convenience sampling, 3021 patients were eligible for the base case analysis (1415 hip, 1047 distal forearm, and 559 vertebral fractures). The mean (SD) difference between HSUV before and after fracture for hip, vertebral, and distal forearm fracture was estimated at 0.89 (0.40), 0.67 (0.45), and 0.48 (0.34), respectively (
p
< 0.001 for all fracture types). Eighteen months after fracture, mean HSUVs were lower than before the fracture in patients with hip fracture (0.66 vs. 0.77
p
< 0.001) and vertebral fracture (0.70 vs. 0.83
p
< 0.001). Hospitalization and higher recalled pre-fracture QoL were associated with increased QoL impact for all fracture types.
Conclusions
Hip, vertebral, and distal forearm fractures incur substantial loss in QoL and for patients with hip or vertebral fracture, QoL is markedly impaired for at least 18 months.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Forearm</subject><subject>Forearm Injuries - rehabilitation</subject><subject>Fractures</subject><subject>Hip</subject><subject>Hip Fractures - rehabilitation</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporotic Fractures - rehabilitation</subject><subject>Psychometrics</subject><subject>Quality of Life</subject><subject>Recurrence</subject><subject>Rheumatology</subject><subject>Sensitivity analysis</subject><subject>Socioeconomic Factors</subject><subject>Spinal Fractures - rehabilitation</subject><subject>Vertebrae</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9u1DAQxi1ERbcLD8AFWeLCoQH_Sxwf0aqUSpWqApW4WU4y7qY4cbAdqpU48BA8AM_SR-mT4NUuFULiMmONf_PZMx9Czyl5TQmRbyIhVNUFobIQfBseoQUVnBdMVeVjtCCKy0IJ-vkQHcV4Q3KPUvIJOmSKcVJSukDfL2fj-rTB3mLXW8DWBzxPOHlM67tfgx_TOmJjEwTs_G0BI4TrDV730zH-BiFBE4w7xmbscNfHZNxWAEwYsA2mTXOAeP_jZ46zSzHX_IDTGvDZ6urDxcen6MAaF-HZPi_R1buTT6v3xfnF6dnq7XnRClmlwrCOMxCVKOtK2LbulJClKU3HhLS2ZLyRrarqjjaM1jxnCVzUjbV5J2Daki9RsdONtzDNjZ5CP5iw0d70el_6kk-ghaKqVJl_teOn4L_OEJMe-tiCc2YEP0dNlazy6mXNMvryH_TGz2HM02QqLzsbVNFM0R3VBh9jAPvwBUr01kq9s1JnUb21MoclerFXnpsBuoeOP95lgO2nylfjNYS_nv6v6m9wmKsf</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Svedbom, A.</creator><creator>Borgstöm, F.</creator><creator>Hernlund, E.</creator><creator>Ström, O.</creator><creator>Alekna, V.</creator><creator>Bianchi, M. L.</creator><creator>Clark, P.</creator><creator>Curiel, M. D.</creator><creator>Dimai, H. P.</creator><creator>Jürisson, M.</creator><creator>Kallikorm, R.</creator><creator>Lember, M.</creator><creator>Lesnyak, O.</creator><creator>McCloskey, E.</creator><creator>Sanders, K. M.</creator><creator>Silverman, S.</creator><creator>Solodovnikov, A.</creator><creator>Tamulaitiene, M.</creator><creator>Thomas, T.</creator><creator>Toroptsova, N.</creator><creator>Uusküla, A.</creator><creator>Tosteson, A. N. A.</creator><creator>Jönsson, B.</creator><creator>Kanis, J. A.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20180301</creationdate><title>Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS</title><author>Svedbom, A. ; Borgstöm, F. ; Hernlund, E. ; Ström, O. ; Alekna, V. ; Bianchi, M. L. ; Clark, P. ; Curiel, M. D. ; Dimai, H. P. ; Jürisson, M. ; Kallikorm, R. ; Lember, M. ; Lesnyak, O. ; McCloskey, E. ; Sanders, K. M. ; Silverman, S. ; Solodovnikov, A. ; Tamulaitiene, M. ; Thomas, T. ; Toroptsova, N. ; Uusküla, A. ; Tosteson, A. N. A. ; Jönsson, B. ; Kanis, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-a2d32e4645864fc8d9475a5ad247ff523b7c968d1b21838d17e348bff317eac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Forearm</topic><topic>Forearm Injuries - rehabilitation</topic><topic>Fractures</topic><topic>Hip</topic><topic>Hip Fractures - rehabilitation</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporotic Fractures - rehabilitation</topic><topic>Psychometrics</topic><topic>Quality of Life</topic><topic>Recurrence</topic><topic>Rheumatology</topic><topic>Sensitivity analysis</topic><topic>Socioeconomic Factors</topic><topic>Spinal Fractures - rehabilitation</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svedbom, A.</creatorcontrib><creatorcontrib>Borgstöm, F.</creatorcontrib><creatorcontrib>Hernlund, E.</creatorcontrib><creatorcontrib>Ström, O.</creatorcontrib><creatorcontrib>Alekna, V.</creatorcontrib><creatorcontrib>Bianchi, M. L.</creatorcontrib><creatorcontrib>Clark, P.</creatorcontrib><creatorcontrib>Curiel, M. D.</creatorcontrib><creatorcontrib>Dimai, H. P.</creatorcontrib><creatorcontrib>Jürisson, M.</creatorcontrib><creatorcontrib>Kallikorm, R.</creatorcontrib><creatorcontrib>Lember, M.</creatorcontrib><creatorcontrib>Lesnyak, O.</creatorcontrib><creatorcontrib>McCloskey, E.</creatorcontrib><creatorcontrib>Sanders, K. M.</creatorcontrib><creatorcontrib>Silverman, S.</creatorcontrib><creatorcontrib>Solodovnikov, A.</creatorcontrib><creatorcontrib>Tamulaitiene, M.</creatorcontrib><creatorcontrib>Thomas, T.</creatorcontrib><creatorcontrib>Toroptsova, N.</creatorcontrib><creatorcontrib>Uusküla, A.</creatorcontrib><creatorcontrib>Tosteson, A. N. A.</creatorcontrib><creatorcontrib>Jönsson, B.</creatorcontrib><creatorcontrib>Kanis, J. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svedbom, A.</au><au>Borgstöm, F.</au><au>Hernlund, E.</au><au>Ström, O.</au><au>Alekna, V.</au><au>Bianchi, M. L.</au><au>Clark, P.</au><au>Curiel, M. D.</au><au>Dimai, H. P.</au><au>Jürisson, M.</au><au>Kallikorm, R.</au><au>Lember, M.</au><au>Lesnyak, O.</au><au>McCloskey, E.</au><au>Sanders, K. M.</au><au>Silverman, S.</au><au>Solodovnikov, A.</au><au>Tamulaitiene, M.</au><au>Thomas, T.</au><au>Toroptsova, N.</au><au>Uusküla, A.</au><au>Tosteson, A. N. A.</au><au>Jönsson, B.</au><au>Kanis, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>29</volume><issue>3</issue><spage>557</spage><epage>566</epage><pages>557-566</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months.
Introduction
The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures. To date, 11 countries have participated in the study: Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, the UK, and the USA. The objective of this paper is to describe the QoL impact of hip, vertebral, and distal forearm fracture.
Methods
Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall) and at 4, 12, and 18 months after fracture. Quality of life was measured as health state utility values (HSUVs) derived from the EQ-5D-3L. Complete case analysis was conducted as the base case with available case and multiple imputation performed as sensitivity analyses. Multivariate analysis was performed to explore predictors of QoL impact of fracture.
Results
Among 5456 patients enrolled using convenience sampling, 3021 patients were eligible for the base case analysis (1415 hip, 1047 distal forearm, and 559 vertebral fractures). The mean (SD) difference between HSUV before and after fracture for hip, vertebral, and distal forearm fracture was estimated at 0.89 (0.40), 0.67 (0.45), and 0.48 (0.34), respectively (
p
< 0.001 for all fracture types). Eighteen months after fracture, mean HSUVs were lower than before the fracture in patients with hip fracture (0.66 vs. 0.77
p
< 0.001) and vertebral fracture (0.70 vs. 0.83
p
< 0.001). Hospitalization and higher recalled pre-fracture QoL were associated with increased QoL impact for all fracture types.
Conclusions
Hip, vertebral, and distal forearm fractures incur substantial loss in QoL and for patients with hip or vertebral fracture, QoL is markedly impaired for at least 18 months.</abstract><cop>London</cop><pub>Springer London</pub><pmid>29230511</pmid><doi>10.1007/s00198-017-4317-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Osteoporosis international, 2018-03, Vol.29 (3), p.557-566 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_491959 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Aged, 80 and over Endocrinology Female Forearm Forearm Injuries - rehabilitation Fractures Hip Hip Fractures - rehabilitation Hospitalization - statistics & numerical data Humans Male Medicine Medicine & Public Health Middle Aged Multivariate analysis Original Article Orthopedics Osteoporosis Osteoporotic Fractures - rehabilitation Psychometrics Quality of Life Recurrence Rheumatology Sensitivity analysis Socioeconomic Factors Spinal Fractures - rehabilitation Vertebrae |
| title | Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T19%3A30%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quality%20of%20life%20for%20up%20to%2018%C2%A0months%20after%20low-energy%20hip,%20vertebral,%20and%20distal%20forearm%20fractures%E2%80%94results%20from%20the%20ICUROS&rft.jtitle=Osteoporosis%20international&rft.au=Svedbom,%20A.&rft.date=2018-03-01&rft.volume=29&rft.issue=3&rft.spage=557&rft.epage=566&rft.pages=557-566&rft.issn=0937-941X&rft.eissn=1433-2965&rft_id=info:doi/10.1007/s00198-017-4317-4&rft_dat=%3Cproquest_swepu%3E1976001782%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1999701961&rft_id=info:pmid/29230511&rfr_iscdi=true |