Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials

Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of t...

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Veröffentlicht in:	The lancet oncology 2018-01, Vol.19 (1), p.27-39
Hauptverfasser:	Asselain, Bernard, Barlow, William, Bergh, Jonas, Bergsten-Nordström, Elizabeth, Bliss, Judith, Boccardo, Francesco, Boddington, Clare, Bogaerts, Jan, Bradley, Rosie, Brain, Etienne, Braybrooke, Jeremy, Broet, Philippe, Bryant, John, Burrett, Julie, Cameron, David, Clarke, Mike, Coates, Alan, Coleman, Robert, Coombes, Raoul Charles, Correa, Candace, Costantino, Joe, Cuzick, Jack, Davidson, Nancy, Davies, Christina, Davies, Lucy, Di Leo, Angelo, Dodwell, David, Dowsett, Mitch, Evans, Vaughan, Ewertz, Marianne, Fisher, Bernard, Forbes, John, Ford, Leslie, Gazet, Jean-Claude, Gelber, Richard, Gettins, Lucy, Gianni, Luca, Gnant, Michael, Godwin, Jon, Goldhirsch, Aron, Goodwin, Pamela, Gray, Richard, Hill, Catherine, Ingle, James, Jagsi, Reshma, Jakesz, Raimund, James, Sam, Janni, Wolfgang, Liu, Hui, Liu, Zulian, Lohrisch, Caroline, Loibl, Sibylle, Mamounas, Eleftherios, Mannu, Gurdeep, Martín, Miguel, Mathoulin, Simone, Mauriac, Louis, McGale, Paul, Morris, Philip, Mukai, Hirofumi, Norton, Larry, Ohashi, Yasuo, Olivotto, Ivo, Paik, Soon, Peto, Richard, Piccart, Martine, Pierce, Lori, Poortmans, Philip, Powles, Trevor, Pritchard, Kathy, Ragaz, Joseph, Raina, Vinod, Ravdin, Peter, Read, Simon, Regan, Meredith, Robertson, John, Rutgers, Emiel, Scholl, Suzy, Slamon, Dennis, Sölkner, Lidija, Steinberg, Seth, Sutcliffe, Rosemary, Swain, Sandra, Taylor, Carolyn, Tutt, Andrew, Valagussa, Pinuccia, van de Velde, Cornelis, van der Hage, Jos, Viale, Giuseppe, von Minckwitz, Gunter, Wang, Yaochen, Wang, Zhe, Wang, Xiang, Whelan, Tim, Wilcken, Nicholas, Winer, Eric, Wolmark, Norman, Wood, William, Zambetti, Milvia, Zujewski, Jo Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anthracycline Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Biopsy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer and Oncology Cancer och onkologi Cancer therapies Chemotherapy Chemotherapy, Adjuvant Clinical Medicine Clinical trials Disease Progression Female Humans Investigations Klinisk medicin Mammography Mastectomy Mastectomy, Segmental Medical and Health Sciences Medical research Medicin och hälsovetenskap Meta-analysis Middle Aged Mortality Neoadjuvant Therapy - adverse effects Neoadjuvant Therapy - mortality Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Staging Patients Radiation therapy Randomized Controlled Trials as Topic Risk Factors Statistics Surgery Systematic review Time Factors Treatment Outcome Trends Tumors Womens health
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