The Missing Siblings of Infants Born Preterm
Parents of very or extremely low birth weight infants have fewer subsequent children after preterm birth. Whether this applies to parents of less preterm infants is unknown. In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Fi...
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| Veröffentlicht in: | Pediatrics (Evanston) 2018-01, Vol.141 (1), p.1 |
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| creator | Alenius, Suvi Kajantie, Eero Sund, Reijo Näsänen-Gilmore, Pieta Vääräsmäki, Marja Gissler, Mika Hovi, Petteri |
| description | Parents of very or extremely low birth weight infants have fewer subsequent children after preterm birth. Whether this applies to parents of less preterm infants is unknown.
In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Finland between January 1, 1987, and September 30, 1990, and their parents. Quantitative contribution of gestational age of child to the birth of parental subsequent children was assessed by multivariate Cox regression models, stratifying by the number of previous children. The impact of gestational age on sibling count was estimated at individual and population level.
Mothers of extremely preterm (23-27 completed weeks) infants were, compared with mothers of term infants (39-41 weeks), less likely to have a subsequent live-born child (adjusted hazard ratio [HR]: 0.74; 95% confidence interval: 0.63-0.86). Corresponding HRs and confidence intervals were as follows: 28 to 31 weeks: 0.72 (0.65-0.80), 32 to 33 weeks: 0.82 (0.74-0.90), and 34 to 36 weeks: 0.90 (0.87-0.93). These HRs were consistent with those of fathers and couples. The cohort included 8002 firstborn preterm children, of whom 356 (4.4%) died in infancy. The 8002 children had a total of 13 826 subsequent siblings (1138 less than expected); per 1000 preterm births, this translates to the death of 44 preterm infants and 142 missing subsequent siblings.
Families with a preterm singleton child have fewer subsequent children. In a high-income country, the main population effect of preterm birth is caused by these "missing siblings," whose number exceeds the number of those preterm infants who die. |
| doi_str_mv | 10.1542/peds.2017-1354 |
| format | Article |
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In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Finland between January 1, 1987, and September 30, 1990, and their parents. Quantitative contribution of gestational age of child to the birth of parental subsequent children was assessed by multivariate Cox regression models, stratifying by the number of previous children. The impact of gestational age on sibling count was estimated at individual and population level.
Mothers of extremely preterm (23-27 completed weeks) infants were, compared with mothers of term infants (39-41 weeks), less likely to have a subsequent live-born child (adjusted hazard ratio [HR]: 0.74; 95% confidence interval: 0.63-0.86). Corresponding HRs and confidence intervals were as follows: 28 to 31 weeks: 0.72 (0.65-0.80), 32 to 33 weeks: 0.82 (0.74-0.90), and 34 to 36 weeks: 0.90 (0.87-0.93). These HRs were consistent with those of fathers and couples. The cohort included 8002 firstborn preterm children, of whom 356 (4.4%) died in infancy. The 8002 children had a total of 13 826 subsequent siblings (1138 less than expected); per 1000 preterm births, this translates to the death of 44 preterm infants and 142 missing subsequent siblings.
Families with a preterm singleton child have fewer subsequent children. In a high-income country, the main population effect of preterm birth is caused by these "missing siblings," whose number exceeds the number of those preterm infants who die.</description><identifier>ISSN: 0031-4005</identifier><identifier>ISSN: 1098-4275</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2017-1354</identifier><identifier>PMID: 29247118</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adult ; Attitude to Health ; Babies ; Birth weight ; Birth weight, Low ; Children ; Cohort Studies ; Congenital Abnormalities - diagnosis ; Congenital Abnormalities - epidemiology ; Female ; Finland ; Gestational age ; Health aspects ; Humans ; Infant ; Infant Mortality - trends ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Infants ; Infants (Premature) ; Low birth weight ; Male ; Medicin och hälsovetenskap ; Parents & parenting ; Parents - psychology ; Pediatrics ; Pregnancy ; Premature birth ; Premature infants ; Proportional Hazards Models ; Registries ; Regression analysis ; Retrospective Studies ; Sibling relations ; Siblings</subject><ispartof>Pediatrics (Evanston), 2018-01, Vol.141 (1), p.1</ispartof><rights>Copyright © 2018 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Jan 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-43ede5d19f9fbbeba78486fa90364a7e61e7cd506e5e4baa7b7d8267d51206bd3</citedby><cites>FETCH-LOGICAL-c489t-43ede5d19f9fbbeba78486fa90364a7e61e7cd506e5e4baa7b7d8267d51206bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29247118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:137374452$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Alenius, Suvi</creatorcontrib><creatorcontrib>Kajantie, Eero</creatorcontrib><creatorcontrib>Sund, Reijo</creatorcontrib><creatorcontrib>Näsänen-Gilmore, Pieta</creatorcontrib><creatorcontrib>Vääräsmäki, Marja</creatorcontrib><creatorcontrib>Gissler, Mika</creatorcontrib><creatorcontrib>Hovi, Petteri</creatorcontrib><title>The Missing Siblings of Infants Born Preterm</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Parents of very or extremely low birth weight infants have fewer subsequent children after preterm birth. Whether this applies to parents of less preterm infants is unknown.
In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Finland between January 1, 1987, and September 30, 1990, and their parents. Quantitative contribution of gestational age of child to the birth of parental subsequent children was assessed by multivariate Cox regression models, stratifying by the number of previous children. The impact of gestational age on sibling count was estimated at individual and population level.
Mothers of extremely preterm (23-27 completed weeks) infants were, compared with mothers of term infants (39-41 weeks), less likely to have a subsequent live-born child (adjusted hazard ratio [HR]: 0.74; 95% confidence interval: 0.63-0.86). Corresponding HRs and confidence intervals were as follows: 28 to 31 weeks: 0.72 (0.65-0.80), 32 to 33 weeks: 0.82 (0.74-0.90), and 34 to 36 weeks: 0.90 (0.87-0.93). These HRs were consistent with those of fathers and couples. The cohort included 8002 firstborn preterm children, of whom 356 (4.4%) died in infancy. The 8002 children had a total of 13 826 subsequent siblings (1138 less than expected); per 1000 preterm births, this translates to the death of 44 preterm infants and 142 missing subsequent siblings.
Families with a preterm singleton child have fewer subsequent children. In a high-income country, the main population effect of preterm birth is caused by these "missing siblings," whose number exceeds the number of those preterm infants who die.</description><subject>Adult</subject><subject>Attitude to Health</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Birth weight, Low</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Congenital Abnormalities - diagnosis</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Female</subject><subject>Finland</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Mortality - trends</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Low birth weight</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Parents & parenting</subject><subject>Parents - psychology</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Premature infants</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Sibling relations</subject><subject>Siblings</subject><issn>0031-4005</issn><issn>1098-4275</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1r3DAQhkVJababXHsMhl56qLf6lnVMlnxByhaSnIVkjbdOvNZWsmny7yuzmwQK0WWEeF4xMw9CXwheEMHpjy34tKCYqJIwwT-gGcG6KjlV4gDNMGak5BiLQ_Q5pQeMMReKfkKHVFOuCKlm6Pvdbyh-tim1_bq4bV2XaypCU1z3je2HVJyF2Be_IgwQN0foY2O7BMf7Okf3F-d3y6vyZnV5vTy9KWte6aHkDDwIT3SjG-fAWVXxSjZWYya5VSAJqNoLLEEAd9Yqp3xFpfKCUCydZ3NU7v5Nf2E7OrON7cbGZxNsa_ZPj_kGhmtSMZl5_S6_jcG_hV6ChCmmOBc0Z7_tshn8M0IazKZNNXSd7SGMyRCt8tGM4Yx-_Q99CGPs8yYypankmDPy1vzadmDavg79AE9DHboO1mDyopYrcyryvFmPnPjFjq9jSClC89o-wWZybCbHZnJsJsc5cLJvY3Qb8K_4i1T2D0BuoM8</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Alenius, Suvi</creator><creator>Kajantie, Eero</creator><creator>Sund, Reijo</creator><creator>Näsänen-Gilmore, Pieta</creator><creator>Vääräsmäki, Marja</creator><creator>Gissler, Mika</creator><creator>Hovi, Petteri</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>201801</creationdate><title>The Missing Siblings of Infants Born Preterm</title><author>Alenius, Suvi ; Kajantie, Eero ; Sund, Reijo ; Näsänen-Gilmore, Pieta ; Vääräsmäki, Marja ; Gissler, Mika ; Hovi, Petteri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-43ede5d19f9fbbeba78486fa90364a7e61e7cd506e5e4baa7b7d8267d51206bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Attitude to Health</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Birth weight, Low</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Congenital Abnormalities - diagnosis</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Female</topic><topic>Finland</topic><topic>Gestational age</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Mortality - trends</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>Low birth weight</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Parents & parenting</topic><topic>Parents - psychology</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Premature infants</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Sibling relations</topic><topic>Siblings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alenius, Suvi</creatorcontrib><creatorcontrib>Kajantie, Eero</creatorcontrib><creatorcontrib>Sund, Reijo</creatorcontrib><creatorcontrib>Näsänen-Gilmore, Pieta</creatorcontrib><creatorcontrib>Vääräsmäki, Marja</creatorcontrib><creatorcontrib>Gissler, Mika</creatorcontrib><creatorcontrib>Hovi, Petteri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alenius, Suvi</au><au>Kajantie, Eero</au><au>Sund, Reijo</au><au>Näsänen-Gilmore, Pieta</au><au>Vääräsmäki, Marja</au><au>Gissler, Mika</au><au>Hovi, Petteri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Missing Siblings of Infants Born Preterm</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2018-01</date><risdate>2018</risdate><volume>141</volume><issue>1</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><issn>1098-4275</issn><eissn>1098-4275</eissn><abstract>Parents of very or extremely low birth weight infants have fewer subsequent children after preterm birth. Whether this applies to parents of less preterm infants is unknown.
In this nationwide cohort study, we identified all 230 308 traceable (>99%) singletons (9983 preterm, 4.3%) live born in Finland between January 1, 1987, and September 30, 1990, and their parents. Quantitative contribution of gestational age of child to the birth of parental subsequent children was assessed by multivariate Cox regression models, stratifying by the number of previous children. The impact of gestational age on sibling count was estimated at individual and population level.
Mothers of extremely preterm (23-27 completed weeks) infants were, compared with mothers of term infants (39-41 weeks), less likely to have a subsequent live-born child (adjusted hazard ratio [HR]: 0.74; 95% confidence interval: 0.63-0.86). Corresponding HRs and confidence intervals were as follows: 28 to 31 weeks: 0.72 (0.65-0.80), 32 to 33 weeks: 0.82 (0.74-0.90), and 34 to 36 weeks: 0.90 (0.87-0.93). These HRs were consistent with those of fathers and couples. The cohort included 8002 firstborn preterm children, of whom 356 (4.4%) died in infancy. The 8002 children had a total of 13 826 subsequent siblings (1138 less than expected); per 1000 preterm births, this translates to the death of 44 preterm infants and 142 missing subsequent siblings.
Families with a preterm singleton child have fewer subsequent children. In a high-income country, the main population effect of preterm birth is caused by these "missing siblings," whose number exceeds the number of those preterm infants who die.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>29247118</pmid><doi>10.1542/peds.2017-1354</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Attitude to Health Babies Birth weight Birth weight, Low Children Cohort Studies Congenital Abnormalities - diagnosis Congenital Abnormalities - epidemiology Female Finland Gestational age Health aspects Humans Infant Infant Mortality - trends Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Infants Infants (Premature) Low birth weight Male Medicin och hälsovetenskap Parents & parenting Parents - psychology Pediatrics Pregnancy Premature birth Premature infants Proportional Hazards Models Registries Regression analysis Retrospective Studies Sibling relations Siblings |
| title | The Missing Siblings of Infants Born Preterm |
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