Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer
The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre‐diagnostically....
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 2018-07, Vol.143 (2), p.245-252 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 252 |
|---|---|
| container_issue | 2 |
| container_start_page | 245 |
| container_title | International journal of cancer |
| container_volume | 143 |
| creator | Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. |
| description | The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.
What's new?
The gut bacterium Streptococcus gallolyticus subspecies gallolyticus (SGG) has been associated with colorectal cancer (CRC), but whether this association exists pre‐diagnostically remains unknown. Here the authors performed a serological study in a prospective setting with samples from the European Prospective Investigation into Nutrition and Cancer (EPIC). They demonstrate a positive association of antibody responses to SGG proteins with CRC risk in pre‐diagnostic samples, implicating SGG serology as a new marker for risk of developing CRC. |
| doi_str_mv | 10.1002/ijc.31283 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_490936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047410025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4263-42ecebb2f79e3c3ee0fab5e0d3e506eceda9c4654869bd019faec816354aa66f3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EokvhwB9AlrjAIe04dpz4iFYFWlVqJeBsOc6k8tYbBztptf--Dll6QOLkj3n8yDMvIe8ZnDGA8tzt7BlnZcNfkA0DVRdQsuol2eQaFDXj8oS8SWkHwFgF4jU5KRWva1bzDbm7jSGNaCf3gBQfjJ_N5MJAQ0_NMLk2dAcaMY1hSEinQH9MEccp2GDtnOid8T74w-SWgxk6Gl26X97a4EPMVuOpNYPF-Ja86o1P-O64npJfXy9-br8X1zffLrdfrgsrSskLUaLFti37WiG3HBF601YIHccKZK51RlkhK9FI1XbAVG_QNkzyShgjZc9PSbF60yOOc6vH6PYmHnQwTh-v7vMOtVCguMz8p5UfY_g9Y5r03iWL3psBw5w0U4oDg6apMvrxH3QX5jjkbnQJohZLFAv1eaVsHmyK2D9_gYFeEJ3T0n_SyuyHo3Fu99g9k3_jycD5Cjw6j4f_m_Tl1XZVPgEyLaDt</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047410025</pqid></control><display><type>article</type><title>Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Butt, Julia ; Jenab, Mazda ; Willhauck‐Fleckenstein, Martina ; Michel, Angelika ; Pawlita, Michael ; Kyrø, Cecilie ; Tjønneland, Anne ; Boutron‐Ruault, Marie‐Christine ; Carbonnel, Franck ; Severi, Gianluca ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; la Vecchia, Carlo ; Karakatsani, Anna ; Panico, Salvatore ; Tumino, Rosario ; Agnoli, Claudia ; Palli, Domenico ; Sacerdote, Carlotta ; Bueno‐de‐Mesquita, H. B(as) ; Weiderpass, Elisabete ; Sánchez, Maria‐José ; Bonet Bonet, Catalina ; Huerta, José María ; Ardanaz, Eva ; Bradbury, Kathryn ; Gunter, Marc ; Murphy, Neil ; Freisling, Heinz ; Riboli, Elio ; Tsilidis, Kostas ; Aune, Dagfinn ; Waterboer, Tim ; Hughes, David J.</creator><creatorcontrib>Butt, Julia ; Jenab, Mazda ; Willhauck‐Fleckenstein, Martina ; Michel, Angelika ; Pawlita, Michael ; Kyrø, Cecilie ; Tjønneland, Anne ; Boutron‐Ruault, Marie‐Christine ; Carbonnel, Franck ; Severi, Gianluca ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; la Vecchia, Carlo ; Karakatsani, Anna ; Panico, Salvatore ; Tumino, Rosario ; Agnoli, Claudia ; Palli, Domenico ; Sacerdote, Carlotta ; Bueno‐de‐Mesquita, H. B(as) ; Weiderpass, Elisabete ; Sánchez, Maria‐José ; Bonet Bonet, Catalina ; Huerta, José María ; Ardanaz, Eva ; Bradbury, Kathryn ; Gunter, Marc ; Murphy, Neil ; Freisling, Heinz ; Riboli, Elio ; Tsilidis, Kostas ; Aune, Dagfinn ; Waterboer, Tim ; Hughes, David J.</creatorcontrib><description>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.
What's new?
The gut bacterium Streptococcus gallolyticus subspecies gallolyticus (SGG) has been associated with colorectal cancer (CRC), but whether this association exists pre‐diagnostically remains unknown. Here the authors performed a serological study in a prospective setting with samples from the European Prospective Investigation into Nutrition and Cancer (EPIC). They demonstrate a positive association of antibody responses to SGG proteins with CRC risk in pre‐diagnostic samples, implicating SGG serology as a new marker for risk of developing CRC.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.31283</identifier><identifier>PMID: 29377173</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; antibodies ; Antibodies, Bacterial - metabolism ; Antibody response ; Bacterial Proteins - blood ; Bacterial Proteins - immunology ; bacterial serology ; Cancer ; Case-Control Studies ; Colorectal cancer ; Colorectal carcinoma ; colorectal neoplasms ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - immunology ; Colorectal Neoplasms - microbiology ; Female ; Gastrointestinal Microbiome ; Health risk assessment ; Health risks ; Humans ; Intestinal microflora ; Male ; Medical research ; Microbiomes ; Middle Aged ; Odds Ratio ; prospective cohort ; Prospective Studies ; Proteins ; Regression analysis ; Serology ; Stratification ; Streptococcal Infections - immunology ; Streptococcus ; Streptococcus gallolyticus ; Streptococcus gallolyticus subspecies gallolyticus - immunology ; Streptococcus infections</subject><ispartof>International journal of cancer, 2018-07, Vol.143 (2), p.245-252</ispartof><rights>2018 UICC</rights><rights>2018 UICC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-42ecebb2f79e3c3ee0fab5e0d3e506eceda9c4654869bd019faec816354aa66f3</citedby><cites>FETCH-LOGICAL-c4263-42ecebb2f79e3c3ee0fab5e0d3e506eceda9c4654869bd019faec816354aa66f3</cites><orcidid>0000-0002-8008-5096 ; 0000-0002-9083-8960 ; 0000-0003-3347-8249 ; 0000-0001-7738-8611 ; 0000-0002-5558-2437 ; 0000-0003-3345-7333 ; 0000-0003-1441-897X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.31283$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.31283$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29377173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:138449379$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Butt, Julia</creatorcontrib><creatorcontrib>Jenab, Mazda</creatorcontrib><creatorcontrib>Willhauck‐Fleckenstein, Martina</creatorcontrib><creatorcontrib>Michel, Angelika</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><creatorcontrib>Kyrø, Cecilie</creatorcontrib><creatorcontrib>Tjønneland, Anne</creatorcontrib><creatorcontrib>Boutron‐Ruault, Marie‐Christine</creatorcontrib><creatorcontrib>Carbonnel, Franck</creatorcontrib><creatorcontrib>Severi, Gianluca</creatorcontrib><creatorcontrib>Kaaks, Rudolf</creatorcontrib><creatorcontrib>Kühn, Tilman</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Trichopoulou, Antonia</creatorcontrib><creatorcontrib>la Vecchia, Carlo</creatorcontrib><creatorcontrib>Karakatsani, Anna</creatorcontrib><creatorcontrib>Panico, Salvatore</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Agnoli, Claudia</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Sacerdote, Carlotta</creatorcontrib><creatorcontrib>Bueno‐de‐Mesquita, H. B(as)</creatorcontrib><creatorcontrib>Weiderpass, Elisabete</creatorcontrib><creatorcontrib>Sánchez, Maria‐José</creatorcontrib><creatorcontrib>Bonet Bonet, Catalina</creatorcontrib><creatorcontrib>Huerta, José María</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Bradbury, Kathryn</creatorcontrib><creatorcontrib>Gunter, Marc</creatorcontrib><creatorcontrib>Murphy, Neil</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Tsilidis, Kostas</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Waterboer, Tim</creatorcontrib><creatorcontrib>Hughes, David J.</creatorcontrib><title>Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.
What's new?
The gut bacterium Streptococcus gallolyticus subspecies gallolyticus (SGG) has been associated with colorectal cancer (CRC), but whether this association exists pre‐diagnostically remains unknown. Here the authors performed a serological study in a prospective setting with samples from the European Prospective Investigation into Nutrition and Cancer (EPIC). They demonstrate a positive association of antibody responses to SGG proteins with CRC risk in pre‐diagnostic samples, implicating SGG serology as a new marker for risk of developing CRC.</description><subject>Adult</subject><subject>Aged</subject><subject>antibodies</subject><subject>Antibodies, Bacterial - metabolism</subject><subject>Antibody response</subject><subject>Bacterial Proteins - blood</subject><subject>Bacterial Proteins - immunology</subject><subject>bacterial serology</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>colorectal neoplasms</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Male</subject><subject>Medical research</subject><subject>Microbiomes</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>prospective cohort</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Serology</subject><subject>Stratification</subject><subject>Streptococcal Infections - immunology</subject><subject>Streptococcus</subject><subject>Streptococcus gallolyticus</subject><subject>Streptococcus gallolyticus subspecies gallolyticus - immunology</subject><subject>Streptococcus infections</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kU1v1DAQhi0EokvhwB9AlrjAIe04dpz4iFYFWlVqJeBsOc6k8tYbBztptf--Dll6QOLkj3n8yDMvIe8ZnDGA8tzt7BlnZcNfkA0DVRdQsuol2eQaFDXj8oS8SWkHwFgF4jU5KRWva1bzDbm7jSGNaCf3gBQfjJ_N5MJAQ0_NMLk2dAcaMY1hSEinQH9MEccp2GDtnOid8T74w-SWgxk6Gl26X97a4EPMVuOpNYPF-Ja86o1P-O64npJfXy9-br8X1zffLrdfrgsrSskLUaLFti37WiG3HBF601YIHccKZK51RlkhK9FI1XbAVG_QNkzyShgjZc9PSbF60yOOc6vH6PYmHnQwTh-v7vMOtVCguMz8p5UfY_g9Y5r03iWL3psBw5w0U4oDg6apMvrxH3QX5jjkbnQJohZLFAv1eaVsHmyK2D9_gYFeEJ3T0n_SyuyHo3Fu99g9k3_jycD5Cjw6j4f_m_Tl1XZVPgEyLaDt</recordid><startdate>20180715</startdate><enddate>20180715</enddate><creator>Butt, Julia</creator><creator>Jenab, Mazda</creator><creator>Willhauck‐Fleckenstein, Martina</creator><creator>Michel, Angelika</creator><creator>Pawlita, Michael</creator><creator>Kyrø, Cecilie</creator><creator>Tjønneland, Anne</creator><creator>Boutron‐Ruault, Marie‐Christine</creator><creator>Carbonnel, Franck</creator><creator>Severi, Gianluca</creator><creator>Kaaks, Rudolf</creator><creator>Kühn, Tilman</creator><creator>Boeing, Heiner</creator><creator>Trichopoulou, Antonia</creator><creator>la Vecchia, Carlo</creator><creator>Karakatsani, Anna</creator><creator>Panico, Salvatore</creator><creator>Tumino, Rosario</creator><creator>Agnoli, Claudia</creator><creator>Palli, Domenico</creator><creator>Sacerdote, Carlotta</creator><creator>Bueno‐de‐Mesquita, H. B(as)</creator><creator>Weiderpass, Elisabete</creator><creator>Sánchez, Maria‐José</creator><creator>Bonet Bonet, Catalina</creator><creator>Huerta, José María</creator><creator>Ardanaz, Eva</creator><creator>Bradbury, Kathryn</creator><creator>Gunter, Marc</creator><creator>Murphy, Neil</creator><creator>Freisling, Heinz</creator><creator>Riboli, Elio</creator><creator>Tsilidis, Kostas</creator><creator>Aune, Dagfinn</creator><creator>Waterboer, Tim</creator><creator>Hughes, David J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-8008-5096</orcidid><orcidid>https://orcid.org/0000-0002-9083-8960</orcidid><orcidid>https://orcid.org/0000-0003-3347-8249</orcidid><orcidid>https://orcid.org/0000-0001-7738-8611</orcidid><orcidid>https://orcid.org/0000-0002-5558-2437</orcidid><orcidid>https://orcid.org/0000-0003-3345-7333</orcidid><orcidid>https://orcid.org/0000-0003-1441-897X</orcidid></search><sort><creationdate>20180715</creationdate><title>Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer</title><author>Butt, Julia ; Jenab, Mazda ; Willhauck‐Fleckenstein, Martina ; Michel, Angelika ; Pawlita, Michael ; Kyrø, Cecilie ; Tjønneland, Anne ; Boutron‐Ruault, Marie‐Christine ; Carbonnel, Franck ; Severi, Gianluca ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; la Vecchia, Carlo ; Karakatsani, Anna ; Panico, Salvatore ; Tumino, Rosario ; Agnoli, Claudia ; Palli, Domenico ; Sacerdote, Carlotta ; Bueno‐de‐Mesquita, H. B(as) ; Weiderpass, Elisabete ; Sánchez, Maria‐José ; Bonet Bonet, Catalina ; Huerta, José María ; Ardanaz, Eva ; Bradbury, Kathryn ; Gunter, Marc ; Murphy, Neil ; Freisling, Heinz ; Riboli, Elio ; Tsilidis, Kostas ; Aune, Dagfinn ; Waterboer, Tim ; Hughes, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-42ecebb2f79e3c3ee0fab5e0d3e506eceda9c4654869bd019faec816354aa66f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>antibodies</topic><topic>Antibodies, Bacterial - metabolism</topic><topic>Antibody response</topic><topic>Bacterial Proteins - blood</topic><topic>Bacterial Proteins - immunology</topic><topic>bacterial serology</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>colorectal neoplasms</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - immunology</topic><topic>Colorectal Neoplasms - microbiology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Male</topic><topic>Medical research</topic><topic>Microbiomes</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>prospective cohort</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Serology</topic><topic>Stratification</topic><topic>Streptococcal Infections - immunology</topic><topic>Streptococcus</topic><topic>Streptococcus gallolyticus</topic><topic>Streptococcus gallolyticus subspecies gallolyticus - immunology</topic><topic>Streptococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butt, Julia</creatorcontrib><creatorcontrib>Jenab, Mazda</creatorcontrib><creatorcontrib>Willhauck‐Fleckenstein, Martina</creatorcontrib><creatorcontrib>Michel, Angelika</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><creatorcontrib>Kyrø, Cecilie</creatorcontrib><creatorcontrib>Tjønneland, Anne</creatorcontrib><creatorcontrib>Boutron‐Ruault, Marie‐Christine</creatorcontrib><creatorcontrib>Carbonnel, Franck</creatorcontrib><creatorcontrib>Severi, Gianluca</creatorcontrib><creatorcontrib>Kaaks, Rudolf</creatorcontrib><creatorcontrib>Kühn, Tilman</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Trichopoulou, Antonia</creatorcontrib><creatorcontrib>la Vecchia, Carlo</creatorcontrib><creatorcontrib>Karakatsani, Anna</creatorcontrib><creatorcontrib>Panico, Salvatore</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Agnoli, Claudia</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Sacerdote, Carlotta</creatorcontrib><creatorcontrib>Bueno‐de‐Mesquita, H. B(as)</creatorcontrib><creatorcontrib>Weiderpass, Elisabete</creatorcontrib><creatorcontrib>Sánchez, Maria‐José</creatorcontrib><creatorcontrib>Bonet Bonet, Catalina</creatorcontrib><creatorcontrib>Huerta, José María</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Bradbury, Kathryn</creatorcontrib><creatorcontrib>Gunter, Marc</creatorcontrib><creatorcontrib>Murphy, Neil</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Tsilidis, Kostas</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Waterboer, Tim</creatorcontrib><creatorcontrib>Hughes, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butt, Julia</au><au>Jenab, Mazda</au><au>Willhauck‐Fleckenstein, Martina</au><au>Michel, Angelika</au><au>Pawlita, Michael</au><au>Kyrø, Cecilie</au><au>Tjønneland, Anne</au><au>Boutron‐Ruault, Marie‐Christine</au><au>Carbonnel, Franck</au><au>Severi, Gianluca</au><au>Kaaks, Rudolf</au><au>Kühn, Tilman</au><au>Boeing, Heiner</au><au>Trichopoulou, Antonia</au><au>la Vecchia, Carlo</au><au>Karakatsani, Anna</au><au>Panico, Salvatore</au><au>Tumino, Rosario</au><au>Agnoli, Claudia</au><au>Palli, Domenico</au><au>Sacerdote, Carlotta</au><au>Bueno‐de‐Mesquita, H. B(as)</au><au>Weiderpass, Elisabete</au><au>Sánchez, Maria‐José</au><au>Bonet Bonet, Catalina</au><au>Huerta, José María</au><au>Ardanaz, Eva</au><au>Bradbury, Kathryn</au><au>Gunter, Marc</au><au>Murphy, Neil</au><au>Freisling, Heinz</au><au>Riboli, Elio</au><au>Tsilidis, Kostas</au><au>Aune, Dagfinn</au><au>Waterboer, Tim</au><au>Hughes, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2018-07-15</date><risdate>2018</risdate><volume>143</volume><issue>2</issue><spage>245</spage><epage>252</epage><pages>245-252</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.
What's new?
The gut bacterium Streptococcus gallolyticus subspecies gallolyticus (SGG) has been associated with colorectal cancer (CRC), but whether this association exists pre‐diagnostically remains unknown. Here the authors performed a serological study in a prospective setting with samples from the European Prospective Investigation into Nutrition and Cancer (EPIC). They demonstrate a positive association of antibody responses to SGG proteins with CRC risk in pre‐diagnostic samples, implicating SGG serology as a new marker for risk of developing CRC.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29377173</pmid><doi>10.1002/ijc.31283</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8008-5096</orcidid><orcidid>https://orcid.org/0000-0002-9083-8960</orcidid><orcidid>https://orcid.org/0000-0003-3347-8249</orcidid><orcidid>https://orcid.org/0000-0001-7738-8611</orcidid><orcidid>https://orcid.org/0000-0002-5558-2437</orcidid><orcidid>https://orcid.org/0000-0003-3345-7333</orcidid><orcidid>https://orcid.org/0000-0003-1441-897X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2018-07, Vol.143 (2), p.245-252 |
| issn | 0020-7136 1097-0215 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_490936 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged antibodies Antibodies, Bacterial - metabolism Antibody response Bacterial Proteins - blood Bacterial Proteins - immunology bacterial serology Cancer Case-Control Studies Colorectal cancer Colorectal carcinoma colorectal neoplasms Colorectal Neoplasms - epidemiology Colorectal Neoplasms - immunology Colorectal Neoplasms - microbiology Female Gastrointestinal Microbiome Health risk assessment Health risks Humans Intestinal microflora Male Medical research Microbiomes Middle Aged Odds Ratio prospective cohort Prospective Studies Proteins Regression analysis Serology Stratification Streptococcal Infections - immunology Streptococcus Streptococcus gallolyticus Streptococcus gallolyticus subspecies gallolyticus - immunology Streptococcus infections |
| title | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T04%3A01%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prospective%20evaluation%20of%20antibody%20response%20to%20Streptococcus%20gallolyticus%20and%20risk%20of%20colorectal%20cancer&rft.jtitle=International%20journal%20of%20cancer&rft.au=Butt,%20Julia&rft.date=2018-07-15&rft.volume=143&rft.issue=2&rft.spage=245&rft.epage=252&rft.pages=245-252&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.31283&rft_dat=%3Cproquest_swepu%3E2047410025%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2047410025&rft_id=info:pmid/29377173&rfr_iscdi=true |