Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique myosin that moves toward the minus end of actin filaments, forms a complex w...

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Veröffentlicht in:	Developmental cell 2018-02, Vol.44 (4), p.484-499.e6
Hauptverfasser:	Kruppa, Antonina J., Kishi-Itakura, Chieko, Masters, Thomas A., Rorbach, Joanna E., Grice, Guinevere L., Kendrick-Jones, John, Nathan, James A., Minczuk, Michal, Buss, Folma
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin Cytoskeleton - metabolism Animals Autophagy HeLa Cells Humans Mice Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology mitochondrial quality control Mitophagy MYO6 Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism myosin VI NDP52 OPTN Parkin Phagosomes - metabolism Protein Binding TAX1BP1 Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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