Elevations of metabolic risk factors 20 years or more before diagnosis of type 2 diabetes: Experience from the AMORIS study

Aims To describe trajectories for metabolic risk factors for type 2 diabetes (T2D) up to 25 years prior to diagnosis and to estimate the absolute 20‐year risk for T2D based on a simple set of commonly measured key risk factors. Methods From the Swedish AMORIS cohort we included 296 428 individuals w...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2018-06, Vol.20 (6), p.1419-1426
Hauptverfasser:	Malmström, Håkan, Walldius, Göran, Carlsson, Sofia, Grill, Valdemar, Jungner, Ingmar, Gudbjörnsdottir, Soffia, Kosiborod, Mikhail, Hammar, Niklas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution autoantibodies Biomarkers - metabolism Blood Glucose - metabolism Body Mass Index Body weight carbohydrates Case-Control Studies cohort Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - etiology Diagnosis Endocrinology & Metabolism Endocrinology and Diabetes Endokrinologi och diabetes Fasting Female Follow-Up Studies Glucose Glycated Hemoglobin A - metabolism hazard ratios Humans inflammatory risk factors Insulin lipids Male Medical diagnosis mellitus Metabolism Middle Aged obesity Obesity - blood Obesity - complications onset Overweight Overweight - blood Overweight - complications Prediabetic State - blood Prediabetic State - etiology prediction Risk Factors risk stratification Time Factors trajectories trajectories to type 2 trajectories to type 2 diabetes Triglycerides Triglycerides - metabolism Uric Acid - metabolism whitehall ii
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