LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer

Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1...

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Veröffentlicht in:	International journal of oncology 2018-04, Vol.52 (4), p.1189-1197
Hauptverfasser:	Lindquist, David, Alsina, Fernando C, Herdenberg, Carl, Larsson, Catharina, Höppener, Jo, Wang, Na, Paratcha, Gustavo, Tarján, Miklós, Tot, Tibor, Henriksson, Roger, Hedman, Håkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals C634R Carcinoma, Neuroendocrine - genetics Carcinoma, Neuroendocrine - metabolism Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Care and treatment Development and progression Down-Regulation Gene expression Gene Expression Regulation, Neoplastic - genetics Gene mutation Genetic aspects Health aspects Humans LRIG1 M918T Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism MEN2A MEN2B Mice Mice, Inbred C57BL Mice, Transgenic Mutation Oncology onkologi Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism RET Rodents Studies Thyroid cancer Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Tumor suppressor genes
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