Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Cancer cells adapt to their inherently increased oxidative stress through activation of the glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems effectively kills cancer cells, but such broad inhibition of antioxidant activity also kills normal cells, which is highly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science translational medicine 2018-02, Vol.10 (428)
Hauptverfasser:	Stafford, William C, Peng, Xiaoxiao, Olofsson, Maria Hägg, Zhang, Xiaonan, Luci, Diane K, Lu, Li, Cheng, Qing, Trésaugues, Lionel, Dexheimer, Thomas S, Coussens, Nathan P, Augsten, Martin, Ahlzén, Hanna-Stina Martinsson, Orwar, Owe, Östman, Arne, Stone-Elander, Sharon, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Linder, Stig, Arnér, Elias S J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Cell Death - drug effects Cell Line, Tumor Cytosol - enzymology Enzyme Inhibitors - analysis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use High-Throughput Screening Assays Hydrogen Peroxide - metabolism Male Mice, SCID Neoplasms - drug therapy Oxidation-Reduction Structure-Activity Relationship Thioredoxin Reductase 1 - antagonists & inhibitors Thioredoxin Reductase 1 - chemistry Thioredoxin Reductase 1 - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!