A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-w...

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Veröffentlicht in:	American journal of human genetics 2018-03, Vol.102 (3), p.375-400
Hauptverfasser:	Sung, Yun J., de las Fuentes, Lisa, Ntalla, Ioanna, Lu, Yingchang, Cheng, Ching-Yu, Vojinovic, Dina, Feitosa, Mary F., Dorajoo, Rajkumar, Liu, Yongmei, Matoba, Nana, Gao, Chuan, Giulianini, Franco, Kasturiratne, Anuradhani, Kühnel, Brigitte, ’an Luan, Jian, McKenzie, Colin A., Nelson, Christopher P., Rauramaa, Rainer, Schupf, Nicole, Scott, Robert A., van der Most, Peter J., Wang, Heming, Yanek, Lisa R., Zhang, Weihua, Arking, Dan, Bielak, Lawrence F., Cade, Brian, Caizheng, Yu, Canouil, Mickaël, Chakravarti, Aravinda, Connell, John M., de Mutsert, Renée, Duan, Qing, Eaton, Charles B., Evangelou, Evangelos, Faul, Jessica D., Forouhi, Nita G., Friedlander, Yechiel, Gigante, Bruna, Gu, C. Charles, Gupta, Preeti, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Hunt, Steven, Irvin, Marguerite R., Justice, Anne E., Komulainen, Pirjo, Kooperberg, Charles, Langefeld, Carl D., Launer, Lenore J., Lin, Shiow, Liu, Kiang, Liu, Yeheng, Loh, Marie, Lohman, Kurt K., Meitinger, Thomas, Metspalu, Andres, Nasri, Ubaydah, Padmanabhan, Sandosh, Palmer, Nicholette D., Peters, Annette, Polasek, Ozren, Robino, Antonietta, Robinson, Jennifer G., Sandow, Kevin, Schmidt, Carsten O., Schreiner, Pamela J., Snieder, Harold, Tang, Hua, Taylor, Kent D., Wang, Ya X., Yao, Jie, Yuan, Jian-Min, Zonderman, Alan B., Farrall, Martin, Forrester, Terrence, Franks, Paul W., Froguel, Philippe, Gieger, Christian, Horta, Bernardo Lessa, Newman, Anne B., Pereira, Alexandre C., Redline, Susan, Scott, James, Wagenknecht, Lynne E., Wu, Tangchun, Bouchard, Claude, Levy, Daniel, van Dam, Rob M., Mook-Kanamori, Dennis O., Kelly, Tanika N., Hayward, Caroline, Rotimi, Charles N., Gauderman, W. James, Rice, Kenneth, Munroe, Patricia B., Morrison, Alanna C., Rao, Dabeeru C., Chasman, Daniel I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Medicine blood pressure Blood Pressure - genetics Cell and Molecular Biology Cell- och molekylärbiologi Clinical Medicine Cohort Studies Diastole - genetics Endocrinology and Diabetes Endokrinologi och diabetes Epistasis, Genetic Female Genetic Loci Genome-Wide Association Study GWAS GxE interactions Humans Klinisk medicin Life Sciences lifestyle Male Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper multi-ancestry Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics Racial Groups - genetics Reproducibility of Results Santé publique et épidémiologie smoking Smoking - genetics Systole - genetics
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