Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

Low levels of the long chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) have been implicated in retinopathy of prematurity (ROP). However, oral DHA suffers from poor palatability and is associated with increased bleeding in premature infants. We asked whether oral administration...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2018-02, Vol.59 (2), p.858-869
Hauptverfasser:	Shaw, Lynn Calvin, Li Calzi, Sergio, Li, Nan, Moldovan, Leni, Sengupta-Caballero, Nilanjana, Quigley, Judith Lindsey, Ivan, Mircea, Jun, Bokkyoo, Bazan, Nicolas G, Boulton, Michael Edwin, Busik, Julia, Neu, Josef, Grant, Maria B
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Animals, Newborn Chromatography, High Pressure Liquid Dipeptides - administration & dosage Disease Models, Animal Docosahexaenoic Acids - metabolism Female Male Mice Mice, Inbred C57BL Oxygen - toxicity Pregnancy Retina - metabolism Retinal Cell Biology Retinal Neovascularization - chemically induced Retinal Neovascularization - metabolism Retinal Neovascularization - prevention & control Retinal Vessels - drug effects Retinal Vessels - pathology Retinopathy of Prematurity - chemically induced Retinopathy of Prematurity - metabolism Retinopathy of Prematurity - prevention & control
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