Nanoparticle-Fusion Protein Complexes Protect against Mycobacterium tuberculosis Infection

Tuberculosis (TB) is the leading cause of death from infectious disease, and the current vaccine, Bacillus Calmette-Guerin (BCG), is inadequate. Nanoparticles (NPs) are an emerging vaccine technology, with recent successes in oncology and infectious diseases. NPs have been exploited as antigen deliv...

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Veröffentlicht in:	Molecular therapy 2018-03, Vol.26 (3), p.822-833
Hauptverfasser:	Hart, Peter, Copland, Alastair, Diogo, Gil Reynolds, Harris, Shane, Spallek, Ralf, Oehlmann, Wulf, Singh, Mahavir, Basile, Juan, Rottenberg, Martin, Paul, Matthew John, Reljic, Rajko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - immunology adjuvant Adjuvants, Immunologic Adsorption Animals Antigen-presenting cells Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacillus Calmette-Guerin vaccine Bacterial Proteins - genetics Bacterial Proteins - immunology BCG BCG Vaccine - immunology CD4 antigen CD8 antigen Cell proliferation Cell-mediated immunity Cytokines Cytokines - metabolism Fusion protein immunity Immunity, Cellular Immunity, Mucosal Immunization Immunoglobulin A Immunoglobulin G Immunologic Memory Immunological memory Infections Infectious diseases Inflammation Interferon regulatory factor 3 Licenses Lymphocytes T Medicin och hälsovetenskap Memory cells Mice Mucosa Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Nanoparticles Oncology Original Proteins Recombinant Fusion Proteins - immunology Software Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis Vaccines - immunology Vaccine efficacy Vaccines
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