NCR+ ILC3 maintain larger STAT4 reservoir via T‐BET to regulate type 1 features upon IL‐23 stimulation in mice

Innate lymphoid cells (ILCs) producing IL‐22 and/or IL‐17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier homeostasis and inflammation. Exogenous environmental cues in conjunction with regulated expression of endogenous factors are key determinants...

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Veröffentlicht in:	European journal of immunology 2018-07, Vol.48 (7), p.1174-1180
Hauptverfasser:	Mikami, Yohei, Scarno, Gianluca, Zitti, Beatrice, Shih, Han‐Yu, Kanno, Yuka, Santoni, Angela, O'Shea, John J, Sciumè, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens, Ly - metabolism Cell Differentiation Cell Lineage Cells, Cultured Chromatin remodeling Cytotoxicity Environmental regulations Homeostasis Humans IFN‐γ Immunity, Mucosal Innate lymphoid cells Interferon Interferon-gamma - metabolism Interleukin-17 - metabolism Interleukin-22 Interleukin-23 - metabolism Interleukins - metabolism Intestines - immunology Intestines - pathology Lymphocytes - immunology Lymphoid cells Mice Molecular chains Mucosal immunology Natural Cytotoxicity Triggering Receptor 1 - metabolism Phosphorylation Protein Binding Signal Transduction STAT4 Stat4 protein T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Transcriptome
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