Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associate...

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Veröffentlicht in:	Cancer cell 2018-03, Vol.33 (3), p.417-434.e7
Hauptverfasser:	Mondal, Tanmoy, Juvvuna, Prasanna Kumar, Kirkeby, Agnete, Mitra, Sanhita, Kosalai, Subazini Thankaswamy, Traxler, Larissa, Hertwig, Falk, Wernig-Zorc, Sara, Miranda, Caroline, Deland, Lily, Volland, Ruth, Bartenhagen, Christoph, Bartsch, Deniz, Bandaru, Sashidhar, Engesser, Anne, Subhash, Santhilal, Martinsson, Tommy, Carén, Helena, Akyürek, Levent M., Kurian, Leo, Kanduri, Meena, Huarte, Maite, Kogner, Per, Fischer, Matthias, Kanduri, Chandrasekhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Medicine Biomarkers, Tumor - genetics Cancer CASC15 Cell and Molecular Biology Cell Line, Tumor Cell- och molekylärbiologi CHD7 Clinical Medicine DNA-Binding Proteins - metabolism epigenetics Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Health Sciences Humans Hälsovetenskap Klinisk medicin lncRNA long noncoding RNA Läkemedelskemi Medical and Health Sciences Medical Biotechnology Medical Genetics and Genomics Medicin och hälsovetenskap Medicinal Chemistry Medicinsk bioteknologi Medicinsk genetik och genomik Medicinska och farmaceutiska grundvetenskaper Mice NBAT1 neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology neuronal differentiation Neurosciences Neurovetenskaper RNA, Long Noncoding - genetics SOX9 SOX9 Transcription Factor - genetics Ubiquitin Thiolesterase - genetics ubiquitination USP36
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