Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

Cerebral autosomal‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a familial fatal progressive degenerative disorder. One of the pathological hallmarks of CADASIL is a dramatic reduction of vascular smooth muscle cells (VSMCs) in cerebral arteries. Using VSMCs f...

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Veröffentlicht in:	JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2018-06, Vol.22 (6), p.3016-3024
Hauptverfasser:	Panahi, Mahmod, Yousefi Mesri, Naeimeh, Samuelsson, Eva‐Britt, Coupland, Kirsten G., Forsell, Charlotte, Graff, Caroline, Tikka, Saara, Winblad, Bengt, Viitanen, Matti, Karlström, Helena, Sundström, Erik, Behbahani, Homira
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - pharmacology Arteries Blood platelets CADASIL CADASIL - genetics CADASIL - metabolism CADASIL - pathology Cell culture Cell cycle Cell division Cell growth Cell proliferation Cell Proliferation - genetics Cerebrum Coculture Techniques Endothelial cells Endothelial Cells - metabolism Fibroblasts Flow cytometry Gene expression Gene Expression Regulation - genetics Genes Growth factors Humans Kinases Leukoencephalopathy Medicin och hälsovetenskap Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscles Mutation Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neutralization Neutralizing NOTCH3 Original Patients Placenta Proteins Smooth muscle Transforming growth factor Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming growth factor-b Transforming growth factor‐β Umbilical cord vascular smooth muscle cells
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