A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their dysregulation causes a multitude of diseases. However, the differentiation journeys toward specific hematopoietic lineages remain ill defined, and system-wide disease interpretation remains challenging. Here,...

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Veröffentlicht in:	Blood 2018-05, Vol.131 (21), p.e1-e11
Hauptverfasser:	Dahlin, Joakim S., Hamey, Fiona K., Pijuan-Sala, Blanca, Shepherd, Mairi, Lau, Winnie W.Y., Nestorowa, Sonia, Weinreb, Caleb, Wolock, Samuel, Hannah, Rebecca, Diamanti, Evangelia, Kent, David G., Göttgens, Berthold, Wilson, Nicola K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Differentiation - genetics Cell Line, Tumor Cell Lineage - genetics Cells, Cultured Gene Expression Profiling Hematopoiesis and Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Mice, Knockout Mutation Proto-Oncogene Proteins c-kit - deficiency Proto-Oncogene Proteins c-kit - metabolism Signal Transduction Single-Cell Analysis Transcriptome
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