First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
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| Veröffentlicht in: | Leukemia 2018-10, Vol.32 (10), p.2291-2295 |
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| creator | Hojjat-Farsangi, M. Daneshmanesh, A. H. Khan, A. S. Shetye, J. Mozaffari, F. Kharaziha, P. Rathje, L.-S. Kokhaei, P. Hansson, L. Vågberg, J. Byström, S. Olsson, E. Löfberg, C. Norström, C. Schultz, J. Norin, M. Olin, T. Österborg, A. Mellstedt, H. Moshfegh, A. |
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| doi_str_mv | 10.1038/s41375-018-0113-1 |
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| subjects | 13 13/2 13/31 13/51 14 14/63 38/47 38/79 45/61 631/67/1059/153 64/60 692/699/67/1059/153 82/29 82/47 82/51 96/1 96/106 Acute myelocytic leukemia Apoptosis Apoptosis - drug effects B cells Brief Communication Cancer cells Cancer Research Cell Line, Tumor Cellular signal transduction Chronic lymphocytic leukemia Critical Care Medicine Enzyme inhibitors Genetic aspects Hematology Humans Intensive Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Lymphatic leukemia Lymphocytic leukemia Medicine Medicine & Public Health Oncology Phenols (Class of compounds) Prognosis Protein-tyrosine kinase Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors Signal Transduction - drug effects Small Molecule Libraries - therapeutic use Tyrosine Universities and colleges |
| title | First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells |
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