Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls

Transcription at enhancers is a widespread phenomenon which produces so-called enhancer RNA (eRNA) and occurs in an activity-dependent manner. However, the role of eRNA and its utility in exploring disease-associated changes in enhancer function, and the downstream coding transcripts that they regul...

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Veröffentlicht in:	Molecular psychiatry 2019-11, Vol.24 (11), p.1685-1695
Hauptverfasser:	Hauberg, Mads E., Fullard, John F., Zhu, Lingxue, Cohain, Ariella T., Giambartolomei, Claudia, Misir, Ruth, Reach, Sarah, Johnson, Jessica S., Wang, Minghui, Mattheisen, Manuel, Børglum, Anders Dupont, Zhang, Bin, Sieberts, Solveig K., Peters, Mette A., Domenici, Enrico, Schadt, Eric E., Devlin, Bernie, Sklar, Pamela, Roeder, Kathryn, Roussos, Panos
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 45 45/43 45/91 631/208 631/378 Adult Behavioral Sciences Biological Psychology Brain Case-Control Studies Chromatin Chromatin - genetics Enhancer Elements, Genetic - genetics Enhancers Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation - genetics Genetic aspects Genetic diversity Genetic transcription Genetic variance Genetic variation Genome-wide association studies Genome-Wide Association Study - methods Genomes Humans Male Medicin och hälsovetenskap Medicine Medicine & Public Health Mental disorders Middle Aged Neurosciences Pharmacotherapy Phosphoproteins - genetics Phosphoproteins - metabolism Prefrontal Cortex Promoter Regions, Genetic - genetics Psychiatry Quantitative Trait Loci - genetics Ribonucleic acid RNA RNA - genetics RNA, Untranslated - genetics Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Transcription Transcription, Genetic - genetics Transposase
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