Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:The pharmacokinetics of infused drugs have been modeled without regard for recirculatory or mixing kinetics. We used a unique ketamine dataset with simultaneous arterial and venous blood sampling, during and afte...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2018-08, Vol.129 (2), p.260-270
Hauptverfasser:	Henthorn, Thomas K, Avram, Michael J, Dahan, Albert, Gustafsson, Lars L, Persson, Jan, Krejcie, Tom C, Olofsen, Erik
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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