p53-Autophagy-Metastasis Link
The tumor suppressor p53 as the "guardian of the genome" plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of v...
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| Veröffentlicht in: | CANCERS 2018-05, Vol.10 (5), p.148 |
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| creator | Denisenko, Tatiana V Pivnyuk, Anastasia D Zhivotovsky, Boris |
| description | The tumor suppressor p53 as the "guardian of the genome" plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed. |
| doi_str_mv | 10.3390/cancers10050148 |
| format | Article |
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Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed.</description><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Genomes</subject><subject>Localization</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Necroptosis</subject><subject>p53 Protein</subject><subject>Phagocytosis</subject><subject>Review</subject><subject>Tumor suppressor genes</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNpdkctLAzEQxoMottSePSmCFy9r835chFJ8QcVL7yHJZtttt7vrZlfpf2-ktbTNBDJkfvORyQfANYKPhCg4cqZ0vgkIQgYRlWegj6HACeeKnh_kPTAMYQnjIgQJLi5BDyshicCwD25qRpJx11b1wsw3yYdvTYg7D3fTvFxdgYvMFMEPd-cAzF6eZ5O3ZPr5-j4ZTxNHmWoTSjJPrMNICmR5ZiA3mfXUMsyV8ilGVtpMMgyhx5RChVNkYxiaWuG4IAOQbGXDj687q-smX5tmoyuT693VKmZeUymxZJF_2vKxsvap82XbmOKo7bhS5gs9r741U0IgjKLAw06gqb46H1q9zoPzRWFKX3VBY0ixYAwyGtH7E3RZdU0ZfyNSjFOGoFKRGm0p11QhND7bPwZB_WeWPjErdtwezrDn_60hv1U2kAM</recordid><startdate>20180518</startdate><enddate>20180518</enddate><creator>Denisenko, Tatiana V</creator><creator>Pivnyuk, Anastasia D</creator><creator>Zhivotovsky, Boris</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20180518</creationdate><title>p53-Autophagy-Metastasis Link</title><author>Denisenko, Tatiana V ; 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| identifier | ISSN: 2072-6694 |
| ispartof | CANCERS, 2018-05, Vol.10 (5), p.148 |
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| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Apoptosis Autophagy Cancer Cell cycle Cell death Genomes Localization Metastases Metastasis Necroptosis p53 Protein Phagocytosis Review Tumor suppressor genes |
| title | p53-Autophagy-Metastasis Link |
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