Variants in genes coding for glutathione S-transferases and asthma outcomes in children
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism ( ) was determined in all cohorts (3692...
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| Veröffentlicht in: | Pharmacogenomics 2018-06, Vol.19 (8), p.707-713 |
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| creator | Turner, Steve Francis, Ben Wani, Nuha Vijverberg, Susanne Pino-Yanes, Maria Mukhopadhyay, Somnath Tavendale, Roger Palmer, Colin Burchard, Esteban G Merid, Simon Kebede Melén, Erik Maitland-van der Zee, Anke H the Pharmacogenomics in Childhood Asthma Consortium, on behalf of |
| description | Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (
) was determined in all cohorts (3692 children) and
and
null genotype were determined in three cohorts (2362 children).
null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between
genotypes and asthma severity. Interactions between
genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes. |
| doi_str_mv | 10.2217/pgs-2018-0027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_488272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2326937430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-653a57f0aee253fc86af1bf53073b51824d4543f296326159d337ab0d1e700a03</originalsourceid><addsrcrecordid>eNp1kc9vVCEQx4mxsbV69Gpe4hnlN7yLiWn8lTTx0KpHwvKGt9RdWIGn8b-XddemPfTEwHzmOzN8EXpByWvGqH6zmytmhBpMCNOP0BnVQmBDBHvcY6EYZoKqU_S01ptOUCXIE3TKRm2kMfQMff_mSnSp1SGmYYYEdfB5imkeQi7DvFmaa-uYEwxXuBWXaoDiaqdcmgZX23rrhrw0n7fwT8Kv42YqkJ6hk-A2FZ4fz3P09cP764tP-PLLx88X7y6xl4Q3rCR3UgfiAJjkwRvlAl0FyYnmK0kNE5OQggc2Ks4UlePEuXYrMlHQhDjCzxE-6NbfsFtWdlfi1pU_Nrtoj08_egRWGMM06_zbA98zW5g8pL7V5l7Z_UyKazvnX1b1zxuV6AKvjgIl_1ygNnuTl5L6jpb1EUeuBb8zli-51gLhtgMldu-b7b7ZvW9271vnX94d65b-b1QHxgMQlrYUqD5C8mAPt14RfUzwgPhfxn6ouA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2326937430</pqid></control><display><type>article</type><title>Variants in genes coding for glutathione S-transferases and asthma outcomes in children</title><source>MEDLINE</source><source>SWEPUB Freely available online</source><source>PubMed Central</source><creator>Turner, Steve ; Francis, Ben ; Wani, Nuha ; Vijverberg, Susanne ; Pino-Yanes, Maria ; Mukhopadhyay, Somnath ; Tavendale, Roger ; Palmer, Colin ; Burchard, Esteban G ; Merid, Simon Kebede ; Melén, Erik ; Maitland-van der Zee, Anke H ; the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</creator><creatorcontrib>Turner, Steve ; Francis, Ben ; Wani, Nuha ; Vijverberg, Susanne ; Pino-Yanes, Maria ; Mukhopadhyay, Somnath ; Tavendale, Roger ; Palmer, Colin ; Burchard, Esteban G ; Merid, Simon Kebede ; Melén, Erik ; Maitland-van der Zee, Anke H ; the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</creatorcontrib><description>Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (
) was determined in all cohorts (3692 children) and
and
null genotype were determined in three cohorts (2362 children).
null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between
genotypes and asthma severity. Interactions between
genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.</description><identifier>ISSN: 1462-2416</identifier><identifier>EISSN: 1744-8042</identifier><identifier>DOI: 10.2217/pgs-2018-0027</identifier><identifier>PMID: 29785881</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Air pollution ; Asthma ; Asthma - genetics ; Child ; Children ; Consortia ; Deoxyribonucleic acid ; DNA ; Emergency medical care ; exacerbation ; Families & family life ; Female ; Gene polymorphism ; Genes ; Genetic Predisposition to Disease - genetics ; Genomes ; Genotype ; Genotype & phenotype ; glutathione S-transferase ; Glutathione transferase ; GSTM1 protein ; GSTT1 protein ; Hospitals ; Humans ; Hypotheses ; Male ; Organic Anion Transporters - genetics ; Pediatrics ; Pollutants ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Risk Factors ; severity ; Single-nucleotide polymorphism ; tobacco smoke</subject><ispartof>Pharmacogenomics, 2018-06, Vol.19 (8), p.707-713</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jun 2018</rights><rights>2018 Future Medicine Ltd 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-653a57f0aee253fc86af1bf53073b51824d4543f296326159d337ab0d1e700a03</citedby><cites>FETCH-LOGICAL-c503t-653a57f0aee253fc86af1bf53073b51824d4543f296326159d337ab0d1e700a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021964/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021964/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,552,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29785881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:138408583$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Francis, Ben</creatorcontrib><creatorcontrib>Wani, Nuha</creatorcontrib><creatorcontrib>Vijverberg, Susanne</creatorcontrib><creatorcontrib>Pino-Yanes, Maria</creatorcontrib><creatorcontrib>Mukhopadhyay, Somnath</creatorcontrib><creatorcontrib>Tavendale, Roger</creatorcontrib><creatorcontrib>Palmer, Colin</creatorcontrib><creatorcontrib>Burchard, Esteban G</creatorcontrib><creatorcontrib>Merid, Simon Kebede</creatorcontrib><creatorcontrib>Melén, Erik</creatorcontrib><creatorcontrib>Maitland-van der Zee, Anke H</creatorcontrib><creatorcontrib>the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</creatorcontrib><title>Variants in genes coding for glutathione S-transferases and asthma outcomes in children</title><title>Pharmacogenomics</title><addtitle>Pharmacogenomics</addtitle><description>Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (
) was determined in all cohorts (3692 children) and
and
null genotype were determined in three cohorts (2362 children).
null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between
genotypes and asthma severity. Interactions between
genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.</description><subject>Air pollution</subject><subject>Asthma</subject><subject>Asthma - genetics</subject><subject>Child</subject><subject>Children</subject><subject>Consortia</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Emergency medical care</subject><subject>exacerbation</subject><subject>Families & family life</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>glutathione S-transferase</subject><subject>Glutathione transferase</subject><subject>GSTM1 protein</subject><subject>GSTT1 protein</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Organic Anion Transporters - genetics</subject><subject>Pediatrics</subject><subject>Pollutants</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><subject>severity</subject><subject>Single-nucleotide polymorphism</subject><subject>tobacco 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Steve</creator><creator>Francis, Ben</creator><creator>Wani, Nuha</creator><creator>Vijverberg, Susanne</creator><creator>Pino-Yanes, Maria</creator><creator>Mukhopadhyay, Somnath</creator><creator>Tavendale, Roger</creator><creator>Palmer, Colin</creator><creator>Burchard, Esteban G</creator><creator>Merid, Simon Kebede</creator><creator>Melén, Erik</creator><creator>Maitland-van der Zee, Anke H</creator><creator>the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</creator><general>Future Medicine 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outcomes in children</title><author>Turner, Steve ; Francis, Ben ; Wani, Nuha ; Vijverberg, Susanne ; Pino-Yanes, Maria ; Mukhopadhyay, Somnath ; Tavendale, Roger ; Palmer, Colin ; Burchard, Esteban G ; Merid, Simon Kebede ; Melén, Erik ; Maitland-van der Zee, Anke H ; the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-653a57f0aee253fc86af1bf53073b51824d4543f296326159d337ab0d1e700a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Air pollution</topic><topic>Asthma</topic><topic>Asthma - genetics</topic><topic>Child</topic><topic>Children</topic><topic>Consortia</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Emergency medical care</topic><topic>exacerbation</topic><topic>Families & family life</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>glutathione S-transferase</topic><topic>Glutathione transferase</topic><topic>GSTM1 protein</topic><topic>GSTT1 protein</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Male</topic><topic>Organic Anion Transporters - genetics</topic><topic>Pediatrics</topic><topic>Pollutants</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><topic>severity</topic><topic>Single-nucleotide polymorphism</topic><topic>tobacco smoke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Francis, Ben</creatorcontrib><creatorcontrib>Wani, Nuha</creatorcontrib><creatorcontrib>Vijverberg, Susanne</creatorcontrib><creatorcontrib>Pino-Yanes, Maria</creatorcontrib><creatorcontrib>Mukhopadhyay, Somnath</creatorcontrib><creatorcontrib>Tavendale, Roger</creatorcontrib><creatorcontrib>Palmer, Colin</creatorcontrib><creatorcontrib>Burchard, Esteban G</creatorcontrib><creatorcontrib>Merid, Simon Kebede</creatorcontrib><creatorcontrib>Melén, Erik</creatorcontrib><creatorcontrib>Maitland-van der Zee, Anke H</creatorcontrib><creatorcontrib>the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma 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Nuha</au><au>Vijverberg, Susanne</au><au>Pino-Yanes, Maria</au><au>Mukhopadhyay, Somnath</au><au>Tavendale, Roger</au><au>Palmer, Colin</au><au>Burchard, Esteban G</au><au>Merid, Simon Kebede</au><au>Melén, Erik</au><au>Maitland-van der Zee, Anke H</au><au>the Pharmacogenomics in Childhood Asthma Consortium, on behalf of</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variants in genes coding for glutathione S-transferases and asthma outcomes in children</atitle><jtitle>Pharmacogenomics</jtitle><addtitle>Pharmacogenomics</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>19</volume><issue>8</issue><spage>707</spage><epage>713</epage><pages>707-713</pages><issn>1462-2416</issn><eissn>1744-8042</eissn><abstract>Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (
) was determined in all cohorts (3692 children) and
and
null genotype were determined in three cohorts (2362 children).
null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between
genotypes and asthma severity. Interactions between
genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29785881</pmid><doi>10.2217/pgs-2018-0027</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pharmacogenomics, 2018-06, Vol.19 (8), p.707-713 |
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| language | eng |
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| source | MEDLINE; SWEPUB Freely available online; PubMed Central |
| subjects | Air pollution Asthma Asthma - genetics Child Children Consortia Deoxyribonucleic acid DNA Emergency medical care exacerbation Families & family life Female Gene polymorphism Genes Genetic Predisposition to Disease - genetics Genomes Genotype Genotype & phenotype glutathione S-transferase Glutathione transferase GSTM1 protein GSTT1 protein Hospitals Humans Hypotheses Male Organic Anion Transporters - genetics Pediatrics Pollutants Polymorphism Polymorphism, Single Nucleotide - genetics Risk Factors severity Single-nucleotide polymorphism tobacco smoke |
| title | Variants in genes coding for glutathione S-transferases and asthma outcomes in children |
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