Molecular allergy diagnostics refine characterization of children sensitized to dog dander
Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. We sought to study the association between sensitization to all presently k...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-10, Vol.142 (4), p.1113-1120.e9 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Käck, Ulrika Asarnoj, Anna Grönlund, Hans Borres, Magnus P. van Hage, Marianne Lilja, Gunnar Konradsen, Jon R. |
| description | Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization.
We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs).
Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive.
There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0).
Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.
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| doi_str_mv | 10.1016/j.jaci.2018.05.012 |
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We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs).
Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive.
There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0).
Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.
[Display omitted]</description><identifier>ISSN: 0091-6749</identifier><identifier>ISSN: 1097-6825</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2018.05.012</identifier><identifier>PMID: 29852259</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Allergens ; Allergens - administration & dosage ; Allergens - immunology ; Allergies ; Allergy ; Animals ; Asthma ; Can f 1 ; Can f 2 ; Can f 3 ; Can f 4 ; Can f 5 ; Can f 6 ; Child ; Children ; Dander ; Dander - immunology ; Desensitization, Immunologic ; dog ; Dogs ; Families & family life ; Female ; Humans ; Hypersensitivity - diagnosis ; Hypersensitivity - immunology ; IgE ; Immunoglobulin E ; Immunoglobulin E - immunology ; Immunoglobulins ; Lipocalin ; Lipocalins - administration & dosage ; Lipocalins - immunology ; Male ; Medicin och hälsovetenskap ; molecular allergology ; nasal provocation test ; Patients ; Prostate-Specific Antigen - administration & dosage ; Prostate-Specific Antigen - immunology ; Proteins ; Provocation tests ; Pruritus ; Rhinoconjunctivitis ; Risk factors ; sensitization ; Streptavidin</subject><ispartof>Journal of allergy and clinical immunology, 2018-10, Vol.142 (4), p.1113-1120.e9</ispartof><rights>2018 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-90a2ffc9e77de2f7b1f75668fd7ba2e4a0664b4cb61cf1995589eb47bcd5cb1f3</citedby><cites>FETCH-LOGICAL-c553t-90a2ffc9e77de2f7b1f75668fd7ba2e4a0664b4cb61cf1995589eb47bcd5cb1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2018.05.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29852259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367400$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:139351601$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Käck, Ulrika</creatorcontrib><creatorcontrib>Asarnoj, Anna</creatorcontrib><creatorcontrib>Grönlund, Hans</creatorcontrib><creatorcontrib>Borres, Magnus P.</creatorcontrib><creatorcontrib>van Hage, Marianne</creatorcontrib><creatorcontrib>Lilja, Gunnar</creatorcontrib><creatorcontrib>Konradsen, Jon R.</creatorcontrib><title>Molecular allergy diagnostics refine characterization of children sensitized to dog dander</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization.
We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs).
Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive.
There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0).
Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.
[Display omitted]</description><subject>Adolescent</subject><subject>Allergens</subject><subject>Allergens - administration & dosage</subject><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>Allergy</subject><subject>Animals</subject><subject>Asthma</subject><subject>Can f 1</subject><subject>Can f 2</subject><subject>Can f 3</subject><subject>Can f 4</subject><subject>Can f 5</subject><subject>Can f 6</subject><subject>Child</subject><subject>Children</subject><subject>Dander</subject><subject>Dander - immunology</subject><subject>Desensitization, Immunologic</subject><subject>dog</subject><subject>Dogs</subject><subject>Families & family life</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - diagnosis</subject><subject>Hypersensitivity - immunology</subject><subject>IgE</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulins</subject><subject>Lipocalin</subject><subject>Lipocalins - administration & dosage</subject><subject>Lipocalins - immunology</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>molecular allergology</subject><subject>nasal provocation test</subject><subject>Patients</subject><subject>Prostate-Specific Antigen - administration & dosage</subject><subject>Prostate-Specific Antigen - immunology</subject><subject>Proteins</subject><subject>Provocation tests</subject><subject>Pruritus</subject><subject>Rhinoconjunctivitis</subject><subject>Risk factors</subject><subject>sensitization</subject><subject>Streptavidin</subject><issn>0091-6749</issn><issn>1097-6825</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk-P1SAUxYnROM_RL-DCkLhxYSvQQiFxMxn_JmPcqAs3hMLlSe0rb6DVzHx6ad6bMTEZV8DN7xxu7j0IPaWkpoSKV0M9GBtqRqisCa8JZffQhhLVVUIyfh9tCFG0El2rTtCjnAdS3o1UD9EJU5IzxtUGff8UR7DLaBI24whpe4VdMNsp5jnYjBP4MAG2P0wydoYUrs0c4oSjL7UwugQTzjDlMIdrcHiO2MUtdmZykB6jB96MGZ4cz1P09d3bL-cfqovP7z-en11UlvNmrhQxzHuroOscMN_11HdcCOld1xsGrSFCtH1re0Gtp0pxLhX0bddbx22Bm1NUHXzzb9gvvd6nsDPpSkcT9LH0s9xAt1ISxgqv7uT3Kbq_ohshbVTDqSC0aF_eqX0Tvp3pmLZ6WXRTpk5IwV8c8OJ7uUCe9S5kC-NoJohL1oy0ipe26Or8_B90iEuayuA0o-vfVDZtodiBsinmXLZz2wEleg2FHvQaCr2GQhOuSyiK6NnReul34G4lNykowOsDAGVNvwIknW2AyYILCeysXQz_8_8DND_K4g</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Käck, Ulrika</creator><creator>Asarnoj, Anna</creator><creator>Grönlund, Hans</creator><creator>Borres, Magnus P.</creator><creator>van Hage, Marianne</creator><creator>Lilja, Gunnar</creator><creator>Konradsen, Jon R.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>20181001</creationdate><title>Molecular allergy diagnostics refine characterization of children sensitized to dog dander</title><author>Käck, Ulrika ; 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Molecular allergy diagnostics offer new opportunities for refined characterization.
We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs).
Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive.
There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0).
Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29852259</pmid><doi>10.1016/j.jaci.2018.05.012</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Allergens Allergens - administration & dosage Allergens - immunology Allergies Allergy Animals Asthma Can f 1 Can f 2 Can f 3 Can f 4 Can f 5 Can f 6 Child Children Dander Dander - immunology Desensitization, Immunologic dog Dogs Families & family life Female Humans Hypersensitivity - diagnosis Hypersensitivity - immunology IgE Immunoglobulin E Immunoglobulin E - immunology Immunoglobulins Lipocalin Lipocalins - administration & dosage Lipocalins - immunology Male Medicin och hälsovetenskap molecular allergology nasal provocation test Patients Prostate-Specific Antigen - administration & dosage Prostate-Specific Antigen - immunology Proteins Provocation tests Pruritus Rhinoconjunctivitis Risk factors sensitization Streptavidin |
| title | Molecular allergy diagnostics refine characterization of children sensitized to dog dander |
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