Number of individual ACPA reactivities in synovial fluid immune complexes, but not serum anti-CCP2 levels, associate with inflammation and joint destruction in rheumatoid arthritis

IntroductionIndividual patients with rheumatoid arthritis (RA) show divergent specific anti-citrullinated protein/peptide antibodies (ACPA) patterns, but hitherto no individual ACPA specificity has consistently been linked to RA pathogenesis. ACPA are also implicated in immune complexes (IC)-associa...

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Veröffentlicht in:	Annals of the rheumatic diseases 2018-09, Vol.77 (9), p.1345-1353
Hauptverfasser:	Sohrabian, Azita, Mathsson-Alm, Linda, Hansson, Monika, Knight, Ann, Lysholm, Jörgen, Cornillet, Martin, Skriner, Karl, Serre, Guy, Larsson, Anders, Weitoft, Tomas, Rönnelid, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animal models ant-ccp Anti-Citrullinated Protein Antibodies / analysis Anti-Citrullinated Protein Antibodies / blood Antibody Specificity Antigen-Antibody Complex / analysis Antigen-Antibody Complex / blood Antigen-Antibody Complex / immunology Antigen-antibody complexes Arthritis, Rheumatoid / immunology autoantibodies Basic and Translational Research Case-Control Studies Citrulline Collagen Cytokines Female Fluids Genotype & phenotype Health risk assessment Human health and pathology Humans Immunoglobulins Immunology Infectious diseases Inflammation Joint diseases Knee Laboratories Life Sciences Male Microarray Analysis / methods Middle Aged Peptides Rheumatoid arthritis Rheumatology Severity of Illness Index Studies Synovial fluid Synovial Fluid / immunology Tumor necrosis factor-TNF
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