A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

Abstract Systemic lupus erythematosus (SLE or lupus) (OMIM: 152700) is a chronic autoimmune disease with debilitating inflammation that affects multiple organ systems. The STAT1-STAT4 locus is one of the first and most highly replicated genetic loci associated with lupus risk. We performed a fine-ma...

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Veröffentlicht in:	Human molecular genetics 2018-07, Vol.27 (13), p.2392-2404
Hauptverfasser:	Patel, Zubin H, Lu, Xiaoming, Miller, Daniel, Forney, Carmy R, Lee, Joshua, Lynch, Arthur, Schroeder, Connor, Parks, Lois, Magnusen, Albert F, Chen, Xiaoting, Pujato, Mario, Maddox, Avery, Zoller, Erin E, Namjou, Bahram, Brunner, Hermine I, Henrickson, Michael, Huggins, Jennifer L, Williams, Adrienne H, Ziegler, Julie T, Comeau, Mary E, Marion, Miranda C, Glenn, Stuart B, Adler, Adam, Shen, Nan, Nath, Swapan K, Stevens, Anne M, Freedman, Barry I, Pons-Estel, Bernardo A, Tsao, Betty P, Jacob, Chaim O, Kamen, Diane L, Brown, Elizabeth E, Gilkeson, Gary S, Alarcón, Graciela S, Martin, Javier, Reveille, John D, Anaya, Juan-Manuel, James, Judith A, Sivils, Kathy L, Criswell, Lindsey A, Vilá, Luis M, Petri, Michelle, Scofield, R Hal, Kimberly, Robert P, Edberg, Jeffrey C, Ramsey-Goldman, Rosalind, Bang, So-Young, Lee, Hye-Soon, Bae, Sang-Cheol, Boackle, Susan A, Cunninghame Graham, Deborah, Vyse, Timothy J, Merrill, Joan T, Niewold, Timothy B, Ainsworth, Hannah C, Silverman, Earl D, Weisman, Michael H, Wallace, Daniel J, Raj, Prithvi, Guthridge, Joel M, Gaffney, Patrick M, Kelly, Jennifer A, Alarcón-Riquelme, Marta E, Langefeld, Carl D, Wakeland, Edward K, Kaufman, Kenneth M, Weirauch, Matthew T, Harley, John B, Kottyan, Leah C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Association Studies Female Humans Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - genetics Male Polymorphism, Genetic Quantitative Trait Loci Risk Factors STAT1 Transcription Factor - genetics STAT4 Transcription Factor - genetics
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