Pathogenic Citrulline‐Multispecific B Cell Receptor Clades in Rheumatoid Arthritis

Objective Anti–citrullinated protein antibodies (ACPAs) have proven highly useful as biomarkers for rheumatoid arthritis (RA). However, composition and functionality of the associated autoreactive B cell repertoire have not been directly assessed. We aimed to selectively investigate citrullinated au...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2018-12, Vol.70 (12), p.1933-1945
Hauptverfasser:	Titcombe, Philip J., Wigerblad, Gustaf, Sippl, Natalie, Zhang, Na, Shmagel, Anna K., Sahlström, Peter, Zhang, Yue, Barsness, Laura O., Ghodke‐Puranik, Yogita, Baharpoor, Azar, Hansson, Monika, Israelsson, Lena, Skriner, Karl, Niewold, Timothy B., Klareskog, Lars, Svensson, Camilla I., Amara, Khaled, Malmström, Vivianne, Mueller, Daniel L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Citrullinated Protein Antibodies - blood Anti-Citrullinated Protein Antibodies - immunology Antibodies, Monoclonal - blood Antibodies, Monoclonal - immunology Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - immunology Autoantibodies - blood Autoantibodies - immunology Autoantigens - blood Autoantigens - immunology B-cell receptor Binding Biomarkers Biomarkers - blood Blood Case-Control Studies Cell lineage Citrulline Citrulline - immunology Clustering Cross Reactions Female Filaggrin Flow cytometry Gene sequencing Heavy chains Humans IGL gene Immunoglobulins Lymphocytes B Male Monoclonal antibodies Mutation Pathogenicity Pathogens Patients Peptides Peptides, Cyclic - immunology Phosphopyruvate hydratase Proteins Receptors Receptors, Antigen, B-Cell - blood Receptors, Antigen, B-Cell - immunology Rheumatoid arthritis
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