Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (E...
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| Veröffentlicht in: | Biological psychiatry (1969) 2018-11, Vol.84 (9), p.644-654 |
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| creator | Walton, Esther Jiang, Wenhao Yao, Nailin Fukunaga, Masaki Hashimoto, Ryota Okada, Naohiro Bustillo, Juan R. de Zwarte, Sonja M.C. Hulshoff Pol, Hilleke E. Andreassen, Ole A. Dale, Anders M. Doan, Nhat Trung Gurholt, Tiril P. Hartberg, Cecilie B. Jørgensen, Kjetil N. Melle, Ingrid Westlye, Lars T. Gruber, Oliver Kraemer, Bernd Tordesillas-Gutiérrez, Diana Fullerton, Janice M. Green, Melissa J. Henskens, Frans A. Quidé, Yann Schall, Ulrich Scott, Rodney J. Cairns, Murray J. Tooney, Paul A. Rasser, Paul E. Cooper, Gavin Morris, Derek W. Hong, Elliot Gur, Ruben C. Satterthwaite, Theodore D. Wolf, Daniel H. Mathalon, Daniel H. Potkin, Steven G. Preda, Adrian Voyvodic, James Lim, Kelvin O. McEwen, Sarah Tan, Yunlong Fan, Fengmei Guo, Hua Wan, Ping Bockholt, Henry J. Ehrlich, Stefan Wolthusen, Rick P.F. King, Margaret D. De Haan, Lieuwe de Rossi, Pietro Iorio, Mariangela McKenna, Peter J. Pomarol-Clotet, Edith Kelly, Sinead Whelan, Christopher D. Voineskos, Aristotle N. Ciufolini, Simone Radua, Joaquim Dazzan, Paola Murray, Robin Reis Marques, Tiago Simmons, Andrew Egloff, Laura Harrisberger, Fabienne Riecher-Rössler, Anita Alpert, Kathryn I. Koops, Sanne Bertolino, Alessandro Bonvino, Aurora Di Giorgio, Annabella Stephen, Julia M. Cannon, Dara M. McDonald, Colm Lebedeva, Irina Tomyshev, Alexander S. Akhadov, Tolibjohn Farde, Lars Flyckt, Lena Erhardt, Sophie Schwieler, Lilly Agartz, Ingrid Collste, Karin Victorsson, Pauliina Orhan, Funda Busatto, Geraldo F. Rosa, Pedro G.P. Zanetti, Marcus V. Skoch, Antonin Spaniel, Filip Tomecek, David Hagenaars, Saskia P. McIntosh, Andrew M. Oertel-Knöchel, Viola Uhlmann, Anne Lopez-Jaramillo, Carlos McMahon, Agnes Faskowitz, Joshua I. Thompson, Paul M. Turner, Jessica A. |
| description | The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.
The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia. |
| doi_str_mv | 10.1016/j.biopsych.2018.04.023 |
| format | Article |
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Jiang, Wenhao ; Yao, Nailin ; Fukunaga, Masaki ; Hashimoto, Ryota ; Okada, Naohiro ; Bustillo, Juan R. ; de Zwarte, Sonja M.C. ; Hulshoff Pol, Hilleke E. ; Andreassen, Ole A. ; Dale, Anders M. ; Doan, Nhat Trung ; Gurholt, Tiril P. ; Hartberg, Cecilie B. ; Jørgensen, Kjetil N. ; Melle, Ingrid ; Westlye, Lars T. ; Gruber, Oliver ; Kraemer, Bernd ; Tordesillas-Gutiérrez, Diana ; Fullerton, Janice M. ; Green, Melissa J. ; Henskens, Frans A. ; Quidé, Yann ; Schall, Ulrich ; Scott, Rodney J. ; Cairns, Murray J. ; Tooney, Paul A. ; Rasser, Paul E. ; Cooper, Gavin ; Morris, Derek W. ; Hong, Elliot ; Gur, Ruben C. ; Satterthwaite, Theodore D. ; Wolf, Daniel H. ; Mathalon, Daniel H. ; Potkin, Steven G. ; Preda, Adrian ; Voyvodic, James ; Lim, Kelvin O. ; McEwen, Sarah ; Tan, Yunlong ; Fan, Fengmei ; Guo, Hua ; Wan, Ping ; Bockholt, Henry J. ; Ehrlich, Stefan ; Wolthusen, Rick P.F. ; King, Margaret D. ; De Haan, Lieuwe ; de Rossi, Pietro ; Iorio, Mariangela ; McKenna, Peter J. ; Pomarol-Clotet, Edith ; Kelly, Sinead ; Whelan, Christopher D. ; Voineskos, Aristotle N. ; Ciufolini, Simone ; Radua, Joaquim ; Dazzan, Paola ; Murray, Robin ; Reis Marques, Tiago ; Simmons, Andrew ; Egloff, Laura ; Harrisberger, Fabienne ; Riecher-Rössler, Anita ; Alpert, Kathryn I. ; Koops, Sanne ; Bertolino, Alessandro ; Bonvino, Aurora ; Di Giorgio, Annabella ; Stephen, Julia M. ; Cannon, Dara M. ; McDonald, Colm ; Lebedeva, Irina ; Tomyshev, Alexander S. ; Akhadov, Tolibjohn ; Farde, Lars ; Flyckt, Lena ; Erhardt, Sophie ; Schwieler, Lilly ; Agartz, Ingrid ; Collste, Karin ; Victorsson, Pauliina ; Orhan, Funda ; Busatto, Geraldo F. ; Rosa, Pedro G.P. ; Zanetti, Marcus V. ; Skoch, Antonin ; Spaniel, Filip ; Tomecek, David ; Hagenaars, Saskia P. ; McIntosh, Andrew M. ; Oertel-Knöchel, Viola ; Uhlmann, Anne ; Lopez-Jaramillo, Carlos ; McMahon, Agnes ; Faskowitz, Joshua I. ; Thompson, Paul M. ; Turner, Jessica A.</creator><creatorcontrib>Walton, Esther ; Jiang, Wenhao ; Yao, Nailin ; Fukunaga, Masaki ; Hashimoto, Ryota ; Okada, Naohiro ; Bustillo, Juan R. ; de Zwarte, Sonja M.C. ; Hulshoff Pol, Hilleke E. ; Andreassen, Ole A. ; Dale, Anders M. ; Doan, Nhat Trung ; Gurholt, Tiril P. ; Hartberg, Cecilie B. ; Jørgensen, Kjetil N. ; Melle, Ingrid ; Westlye, Lars T. ; Gruber, Oliver ; Kraemer, Bernd ; Tordesillas-Gutiérrez, Diana ; Fullerton, Janice M. ; Green, Melissa J. ; Henskens, Frans A. ; Quidé, Yann ; Schall, Ulrich ; Scott, Rodney J. ; Cairns, Murray J. ; Tooney, Paul A. ; Rasser, Paul E. ; Cooper, Gavin ; Morris, Derek W. ; Hong, Elliot ; Gur, Ruben C. ; Satterthwaite, Theodore D. ; Wolf, Daniel H. ; Mathalon, Daniel H. ; Potkin, Steven G. ; Preda, Adrian ; Voyvodic, James ; Lim, Kelvin O. ; McEwen, Sarah ; Tan, Yunlong ; Fan, Fengmei ; Guo, Hua ; Wan, Ping ; Bockholt, Henry J. ; Ehrlich, Stefan ; Wolthusen, Rick P.F. ; King, Margaret D. ; De Haan, Lieuwe ; de Rossi, Pietro ; Iorio, Mariangela ; McKenna, Peter J. ; Pomarol-Clotet, Edith ; Kelly, Sinead ; Whelan, Christopher D. ; Voineskos, Aristotle N. ; Ciufolini, Simone ; Radua, Joaquim ; Dazzan, Paola ; Murray, Robin ; Reis Marques, Tiago ; Simmons, Andrew ; Egloff, Laura ; Harrisberger, Fabienne ; Riecher-Rössler, Anita ; Alpert, Kathryn I. ; Koops, Sanne ; Bertolino, Alessandro ; Bonvino, Aurora ; Di Giorgio, Annabella ; Stephen, Julia M. ; Cannon, Dara M. ; McDonald, Colm ; Lebedeva, Irina ; Tomyshev, Alexander S. ; Akhadov, Tolibjohn ; Farde, Lars ; Flyckt, Lena ; Erhardt, Sophie ; Schwieler, Lilly ; Agartz, Ingrid ; Collste, Karin ; Victorsson, Pauliina ; Orhan, Funda ; Busatto, Geraldo F. ; Rosa, Pedro G.P. ; Zanetti, Marcus V. ; Skoch, Antonin ; Spaniel, Filip ; Tomecek, David ; Hagenaars, Saskia P. ; McIntosh, Andrew M. ; Oertel-Knöchel, Viola ; Uhlmann, Anne ; Lopez-Jaramillo, Carlos ; McMahon, Agnes ; Faskowitz, Joshua I. ; Thompson, Paul M. ; Turner, Jessica A. ; Karolinska Schizophrenia Project</creatorcontrib><description>The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.
The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2018.04.023</identifier><identifier>PMID: 29960671</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age of Onset ; Aged ; Brain - diagnostic imaging ; Brain - pathology ; Case-Control Studies ; Child ; Cortical ; Female ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - pathology ; Humans ; Imaging ; Linear Models ; Magnetic Resonance Imaging ; Male ; Meta-analysis ; Middle Aged ; Neuroimaging ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - pathology ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - pathology ; Severity of Illness Index ; Surface area ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - pathology ; Thickness ; Young Adult</subject><ispartof>Biological psychiatry (1969), 2018-11, Vol.84 (9), p.644-654</ispartof><rights>2018 Society of Biological Psychiatry</rights><rights>Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-f22d39342919e9e81431d14b1635da9ff6f51123fd9c5413437ce2faf4e563143</citedby><cites>FETCH-LOGICAL-c478t-f22d39342919e9e81431d14b1635da9ff6f51123fd9c5413437ce2faf4e563143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322318315178$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,26544,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29960671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:139379219$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Jiang, Wenhao</creatorcontrib><creatorcontrib>Yao, Nailin</creatorcontrib><creatorcontrib>Fukunaga, Masaki</creatorcontrib><creatorcontrib>Hashimoto, Ryota</creatorcontrib><creatorcontrib>Okada, Naohiro</creatorcontrib><creatorcontrib>Bustillo, Juan R.</creatorcontrib><creatorcontrib>de Zwarte, Sonja M.C.</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E.</creatorcontrib><creatorcontrib>Andreassen, Ole A.</creatorcontrib><creatorcontrib>Dale, Anders M.</creatorcontrib><creatorcontrib>Doan, Nhat Trung</creatorcontrib><creatorcontrib>Gurholt, Tiril P.</creatorcontrib><creatorcontrib>Hartberg, Cecilie B.</creatorcontrib><creatorcontrib>Jørgensen, Kjetil N.</creatorcontrib><creatorcontrib>Melle, Ingrid</creatorcontrib><creatorcontrib>Westlye, Lars T.</creatorcontrib><creatorcontrib>Gruber, Oliver</creatorcontrib><creatorcontrib>Kraemer, Bernd</creatorcontrib><creatorcontrib>Tordesillas-Gutiérrez, Diana</creatorcontrib><creatorcontrib>Fullerton, Janice M.</creatorcontrib><creatorcontrib>Green, Melissa J.</creatorcontrib><creatorcontrib>Henskens, Frans A.</creatorcontrib><creatorcontrib>Quidé, Yann</creatorcontrib><creatorcontrib>Schall, Ulrich</creatorcontrib><creatorcontrib>Scott, Rodney J.</creatorcontrib><creatorcontrib>Cairns, Murray J.</creatorcontrib><creatorcontrib>Tooney, Paul A.</creatorcontrib><creatorcontrib>Rasser, Paul E.</creatorcontrib><creatorcontrib>Cooper, Gavin</creatorcontrib><creatorcontrib>Morris, Derek W.</creatorcontrib><creatorcontrib>Hong, Elliot</creatorcontrib><creatorcontrib>Gur, Ruben C.</creatorcontrib><creatorcontrib>Satterthwaite, Theodore D.</creatorcontrib><creatorcontrib>Wolf, Daniel H.</creatorcontrib><creatorcontrib>Mathalon, Daniel H.</creatorcontrib><creatorcontrib>Potkin, Steven G.</creatorcontrib><creatorcontrib>Preda, Adrian</creatorcontrib><creatorcontrib>Voyvodic, 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Lena</creatorcontrib><creatorcontrib>Erhardt, Sophie</creatorcontrib><creatorcontrib>Schwieler, Lilly</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><creatorcontrib>Collste, Karin</creatorcontrib><creatorcontrib>Victorsson, Pauliina</creatorcontrib><creatorcontrib>Orhan, Funda</creatorcontrib><creatorcontrib>Busatto, Geraldo F.</creatorcontrib><creatorcontrib>Rosa, Pedro G.P.</creatorcontrib><creatorcontrib>Zanetti, Marcus V.</creatorcontrib><creatorcontrib>Skoch, Antonin</creatorcontrib><creatorcontrib>Spaniel, Filip</creatorcontrib><creatorcontrib>Tomecek, David</creatorcontrib><creatorcontrib>Hagenaars, Saskia P.</creatorcontrib><creatorcontrib>McIntosh, Andrew M.</creatorcontrib><creatorcontrib>Oertel-Knöchel, Viola</creatorcontrib><creatorcontrib>Uhlmann, Anne</creatorcontrib><creatorcontrib>Lopez-Jaramillo, Carlos</creatorcontrib><creatorcontrib>McMahon, Agnes</creatorcontrib><creatorcontrib>Faskowitz, Joshua I.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Turner, Jessica A.</creatorcontrib><creatorcontrib>Karolinska Schizophrenia Project</creatorcontrib><title>Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.
The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cortical</subject><subject>Female</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - pathology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - pathology</subject><subject>Severity of Illness Index</subject><subject>Surface area</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - pathology</subject><subject>Thickness</subject><subject>Young Adult</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>3HK</sourceid><sourceid>D8T</sourceid><recordid>eNqFkc-O0zAQxiMEYsvCKyw-LocU_4uT3ChVKZV2l8Mu4mg5zqRxSexiJ0XlqXhEHLXdKyd7Zn4z32i-JLkheE4wER9388q4fTjqdk4xKeaYzzFlL5IZKXKWUo7py2SGMRYpo5RdJW9C2MUwp5S8Tq5oWQoscjJL_i6dH4xWHfrslbFoUVnne9WZwUBAMcF5ztHG1uZg6lF1Af0wQ4sedWv-uH3rwRqFlK1RhssCLZ0dvOvQ41jtQA8BHWJ1aAGtbKusNnaLHmD0Dm16tZ2iNViI8gE9td6N2xbdw6DQwqruGExAt6uHzfp-8WEaHKZFx_5t8qqJa8C783udfP-yelp-Te--rTfLxV2qeV4MaUNpzUrGaUlKKKEgnJGa8IoIltWqbBrRZIRQ1tSlzjhhnOUaaKMaDplgkb5O0tPc8Bv2YyX33vTKH6VTRp5TP-MPJC9yKkTk35947U0YjJXxjkoSXGRUxrIoI3F7Ivbe_RohDLI3QUPXKQtuDJJiwXKSZZxFVFyGuRA8NM_yBMvJf7mTF__l5L_EXEb_Y-PNWWOseqif2y6GR-DTCYB4u4MBL4M2YDXUxkfHZO3M_zT-AWSPxCs</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Walton, Esther</creator><creator>Jiang, 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F.</creator><creator>Rosa, Pedro G.P.</creator><creator>Zanetti, Marcus V.</creator><creator>Skoch, Antonin</creator><creator>Spaniel, Filip</creator><creator>Tomecek, David</creator><creator>Hagenaars, Saskia P.</creator><creator>McIntosh, Andrew M.</creator><creator>Oertel-Knöchel, Viola</creator><creator>Uhlmann, Anne</creator><creator>Lopez-Jaramillo, Carlos</creator><creator>McMahon, Agnes</creator><creator>Faskowitz, Joshua I.</creator><creator>Thompson, Paul M.</creator><creator>Turner, Jessica A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20181101</creationdate><title>Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium</title><author>Walton, Esther ; Jiang, Wenhao ; Yao, Nailin ; Fukunaga, Masaki ; Hashimoto, Ryota ; Okada, Naohiro ; Bustillo, Juan R. ; de Zwarte, Sonja M.C. ; Hulshoff Pol, Hilleke E. ; Andreassen, Ole A. ; Dale, Anders M. ; Doan, Nhat Trung ; Gurholt, Tiril P. ; Hartberg, Cecilie B. ; Jørgensen, Kjetil N. ; Melle, Ingrid ; Westlye, Lars T. ; Gruber, Oliver ; Kraemer, Bernd ; Tordesillas-Gutiérrez, Diana ; Fullerton, Janice M. ; Green, Melissa J. ; Henskens, Frans A. ; Quidé, Yann ; Schall, Ulrich ; Scott, Rodney J. ; Cairns, Murray J. ; Tooney, Paul A. ; Rasser, Paul E. ; Cooper, Gavin ; Morris, Derek W. ; Hong, Elliot ; Gur, Ruben C. ; Satterthwaite, Theodore D. ; Wolf, Daniel H. ; Mathalon, Daniel H. ; Potkin, Steven G. ; Preda, Adrian ; Voyvodic, James ; Lim, Kelvin O. ; McEwen, Sarah ; Tan, Yunlong ; Fan, Fengmei ; Guo, Hua ; Wan, Ping ; Bockholt, Henry J. ; Ehrlich, Stefan ; Wolthusen, Rick P.F. ; King, Margaret D. ; De Haan, Lieuwe ; de Rossi, Pietro ; Iorio, Mariangela ; McKenna, Peter J. ; Pomarol-Clotet, Edith ; Kelly, Sinead ; Whelan, Christopher D. ; Voineskos, Aristotle N. ; Ciufolini, Simone ; Radua, Joaquim ; Dazzan, Paola ; Murray, Robin ; Reis Marques, Tiago ; Simmons, Andrew ; Egloff, Laura ; Harrisberger, Fabienne ; Riecher-Rössler, Anita ; Alpert, Kathryn I. ; Koops, Sanne ; Bertolino, Alessandro ; Bonvino, Aurora ; Di Giorgio, Annabella ; Stephen, Julia M. ; Cannon, Dara M. ; McDonald, Colm ; Lebedeva, Irina ; Tomyshev, Alexander S. ; Akhadov, Tolibjohn ; Farde, Lars ; Flyckt, Lena ; Erhardt, Sophie ; Schwieler, Lilly ; Agartz, Ingrid ; Collste, Karin ; Victorsson, Pauliina ; Orhan, Funda ; Busatto, Geraldo F. ; Rosa, Pedro G.P. ; Zanetti, Marcus V. ; Skoch, Antonin ; Spaniel, Filip ; Tomecek, David ; Hagenaars, Saskia P. ; McIntosh, Andrew M. ; Oertel-Knöchel, Viola ; Uhlmann, Anne ; Lopez-Jaramillo, Carlos ; McMahon, Agnes ; Faskowitz, Joshua I. ; Thompson, Paul M. ; Turner, Jessica A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-f22d39342919e9e81431d14b1635da9ff6f51123fd9c5413437ce2faf4e563143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cortical</topic><topic>Female</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Frontal Lobe - pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Prefrontal Cortex - pathology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - pathology</topic><topic>Severity of Illness Index</topic><topic>Surface area</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - pathology</topic><topic>Thickness</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Jiang, Wenhao</creatorcontrib><creatorcontrib>Yao, Nailin</creatorcontrib><creatorcontrib>Fukunaga, Masaki</creatorcontrib><creatorcontrib>Hashimoto, Ryota</creatorcontrib><creatorcontrib>Okada, Naohiro</creatorcontrib><creatorcontrib>Bustillo, Juan R.</creatorcontrib><creatorcontrib>de Zwarte, Sonja M.C.</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E.</creatorcontrib><creatorcontrib>Andreassen, Ole A.</creatorcontrib><creatorcontrib>Dale, Anders M.</creatorcontrib><creatorcontrib>Doan, Nhat 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David</creatorcontrib><creatorcontrib>Hagenaars, Saskia P.</creatorcontrib><creatorcontrib>McIntosh, Andrew M.</creatorcontrib><creatorcontrib>Oertel-Knöchel, Viola</creatorcontrib><creatorcontrib>Uhlmann, Anne</creatorcontrib><creatorcontrib>Lopez-Jaramillo, Carlos</creatorcontrib><creatorcontrib>McMahon, Agnes</creatorcontrib><creatorcontrib>Faskowitz, Joshua I.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Turner, Jessica A.</creatorcontrib><creatorcontrib>Karolinska Schizophrenia Project</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walton, Esther</au><au>Jiang, Wenhao</au><au>Yao, Nailin</au><au>Fukunaga, Masaki</au><au>Hashimoto, Ryota</au><au>Okada, Naohiro</au><au>Bustillo, Juan R.</au><au>de Zwarte, Sonja M.C.</au><au>Hulshoff Pol, Hilleke E.</au><au>Andreassen, Ole A.</au><au>Dale, Anders M.</au><au>Doan, Nhat Trung</au><au>Gurholt, Tiril P.</au><au>Hartberg, Cecilie B.</au><au>Jørgensen, Kjetil N.</au><au>Melle, Ingrid</au><au>Westlye, Lars T.</au><au>Gruber, Oliver</au><au>Kraemer, Bernd</au><au>Tordesillas-Gutiérrez, Diana</au><au>Fullerton, Janice M.</au><au>Green, Melissa J.</au><au>Henskens, Frans A.</au><au>Quidé, Yann</au><au>Schall, Ulrich</au><au>Scott, Rodney J.</au><au>Cairns, Murray J.</au><au>Tooney, Paul A.</au><au>Rasser, Paul E.</au><au>Cooper, Gavin</au><au>Morris, Derek W.</au><au>Hong, Elliot</au><au>Gur, Ruben C.</au><au>Satterthwaite, Theodore D.</au><au>Wolf, Daniel H.</au><au>Mathalon, Daniel H.</au><au>Potkin, Steven G.</au><au>Preda, Adrian</au><au>Voyvodic, James</au><au>Lim, Kelvin O.</au><au>McEwen, Sarah</au><au>Tan, Yunlong</au><au>Fan, Fengmei</au><au>Guo, Hua</au><au>Wan, Ping</au><au>Bockholt, Henry J.</au><au>Ehrlich, Stefan</au><au>Wolthusen, Rick P.F.</au><au>King, Margaret D.</au><au>De Haan, Lieuwe</au><au>de Rossi, Pietro</au><au>Iorio, Mariangela</au><au>McKenna, Peter J.</au><au>Pomarol-Clotet, Edith</au><au>Kelly, Sinead</au><au>Whelan, Christopher D.</au><au>Voineskos, Aristotle N.</au><au>Ciufolini, Simone</au><au>Radua, Joaquim</au><au>Dazzan, Paola</au><au>Murray, Robin</au><au>Reis Marques, Tiago</au><au>Simmons, Andrew</au><au>Egloff, Laura</au><au>Harrisberger, Fabienne</au><au>Riecher-Rössler, Anita</au><au>Alpert, Kathryn I.</au><au>Koops, Sanne</au><au>Bertolino, Alessandro</au><au>Bonvino, Aurora</au><au>Di Giorgio, Annabella</au><au>Stephen, Julia M.</au><au>Cannon, Dara M.</au><au>McDonald, Colm</au><au>Lebedeva, Irina</au><au>Tomyshev, Alexander S.</au><au>Akhadov, Tolibjohn</au><au>Farde, Lars</au><au>Flyckt, Lena</au><au>Erhardt, Sophie</au><au>Schwieler, Lilly</au><au>Agartz, Ingrid</au><au>Collste, Karin</au><au>Victorsson, Pauliina</au><au>Orhan, Funda</au><au>Busatto, Geraldo F.</au><au>Rosa, Pedro G.P.</au><au>Zanetti, Marcus V.</au><au>Skoch, Antonin</au><au>Spaniel, Filip</au><au>Tomecek, David</au><au>Hagenaars, Saskia P.</au><au>McIntosh, Andrew M.</au><au>Oertel-Knöchel, Viola</au><au>Uhlmann, Anne</au><au>Lopez-Jaramillo, Carlos</au><au>McMahon, Agnes</au><au>Faskowitz, Joshua I.</au><au>Thompson, Paul M.</au><au>Turner, Jessica A.</au><aucorp>Karolinska Schizophrenia Project</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>84</volume><issue>9</issue><spage>644</spage><epage>654</epage><pages>644-654</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><abstract>The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.
The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29960671</pmid><doi>10.1016/j.biopsych.2018.04.023</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 2018-11, Vol.84 (9), p.644-654 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_487266 |
| source | MEDLINE; NORA - Norwegian Open Research Archives; Elsevier ScienceDirect Journals; SWEPUB Freely available online |
| subjects | Adolescent Adult Age of Onset Aged Brain - diagnostic imaging Brain - pathology Case-Control Studies Child Cortical Female Frontal Lobe - diagnostic imaging Frontal Lobe - pathology Humans Imaging Linear Models Magnetic Resonance Imaging Male Meta-analysis Middle Aged Neuroimaging Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - pathology Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - pathology Severity of Illness Index Surface area Temporal Lobe - diagnostic imaging Temporal Lobe - pathology Thickness Young Adult |
| title | Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium |
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