Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin

Purpose Efavirenz-based combination antiretroviral therapy (cART) is associated with neuropsychiatric adverse events. We investigated the time to onset, duration, clinical implications, impact of pharmacogenetic variations, and anti-tuberculosis co-treatment on efavirenz-associated neuropsychiatric...

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Veröffentlicht in:	European journal of clinical pharmacology 2018-11, Vol.74 (11), p.1405-1415
Hauptverfasser:	Mugusi, Sabina, Ngaimisi, Eliford, Janabi, Mohammed, Mugusi, Ferdinand, Minzi, Omary, Aris, Eric, Bakari, Muhammad, Bertilsson, Leif, Burhenne, Juergen, Sandstrom, Eric, Aklillu, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Africa South of the Sahara Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antibiotics, Antitubercular - administration & dosage Antibiotics, Antitubercular - adverse effects Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - adverse effects Antiretroviral Therapy, Highly Active - methods Antitubercular Agents - therapeutic use Benzoxazines - administration & dosage Benzoxazines - adverse effects Benzoxazines - blood Biomedical and Life Sciences Biomedicine Cohort Studies Demographics Efavirenz Female Genotype Genotyping Health risks HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - genetics HIV Infections - microbiology HIV-1 - isolation & purification Human immunodeficiency virus Humans Incidence Male Medicin och hälsovetenskap Mental Disorders - blood Mental Disorders - chemically induced Mental Disorders - genetics Mental Disorders - microbiology Patients Pharmacogenetics Pharmacology/Toxicology Prospective Studies Rifampin Rifampin - administration & dosage Rifampin - adverse effects Tuberculosis Tuberculosis - blood Tuberculosis - drug therapy Tuberculosis - genetics Tuberculosis - microbiology
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