Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

IgE is an ancient and conserved immunoglobulin isotype with potent immunological function. Nevertheless, the regulation of IgE responses remains an enigma, and evidence of a role for IgE in host defense is limited. Here we report that topical exposure to a common environmental DNA-damaging xenobioti...

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Veröffentlicht in:	Nature immunology 2018-08, Vol.19 (8), p.859-870
Hauptverfasser:	Crawford, Greg, Hayes, Mark David, Seoane, Rocio Castro, Ward, Sophie, Dalessandri, Tim, Lai, Chester, Healy, Eugene, Kipling, David, Proby, Charlotte, Moyes, Colin, Green, Kile, Best, Katie, Haniffa, Muzlifah, Botto, Marina, Dunn-Walters, Deborah, Strid, Jessica
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/580/1884 Animals Anthracenes - toxicity B-Lymphocytes - physiology Biomedical and Life Sciences Biomedicine Carcinogenesis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - immunology Cell Death Cells, Cultured Class switching Complementarity Determining Regions - genetics Complementarity-determining region DNA Damage Environmental DNA Epithelial Cells - physiology Female High-Throughput Nucleotide Sequencing Immunoglobulin Class Switching Immunoglobulin E Immunoglobulin E - genetics Immunoglobulin E - metabolism Immunologic Surveillance Immunology Immunosurveillance Infectious Diseases Intraepithelial Lymphocytes - physiology Lymphocytes Lymphocytes B Lymphocytes T Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental - chemically induced Neoplasms, Experimental - immunology Piperidines - toxicity Prognosis Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - metabolism Receptors, IgE - metabolism Squamous cell carcinoma
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