Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery
•Treating MDR-TB is complicated, long and expensive.•Bedaquiline (BQ) is a new active drug to treat MDR-TB.•No study evaluated safety and effectiveness of surgery in BQ-treated patients.•57 BQ-exposed cases resistant to 7 drugs (median) underwent surgery in 9 countries.•60% of cases initiated BQ aft...
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| Veröffentlicht in: | The Journal of infection 2019-01, Vol.78 (1), p.35-39 |
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| creator | Borisov, Sergey E. D'Ambrosio, Lia Centis, Rosella Tiberi, Simon Dheda, Keertan Alffenaar, Jan-Willem Amale, Rohit Belilowski, Evgeny Bruchfeld, Judith Canneto, Barbara Denholm, Justin Duarte, Raquel Esmail, Aliasgar Filippov, Alex Davies Forsman, Lina Gaga, Mina Ganatra, Shashank Igorevna, Gaida Anastasia Lazaro Mastrapa, Barbara Manfrin, Vinicio Manga, Selene Maryandyshev, Andrey Massard, Gilbert González Montaner, Pablo Mullerpattan, Jai Palmero, Domingo Juan Pontarelli, Agostina Papavasileiou, Apostolos Pontali, Emanuele Romero Leyet, Rodolfo Spanevello, Antonio Udwadia, Zarir Farokh Viggiani, Pietro Visca, Dina Sotgiu, Giovanni Migliori, Giovanni Battista |
| description | •Treating MDR-TB is complicated, long and expensive.•Bedaquiline (BQ) is a new active drug to treat MDR-TB.•No study evaluated safety and effectiveness of surgery in BQ-treated patients.•57 BQ-exposed cases resistant to 7 drugs (median) underwent surgery in 9 countries.•60% of cases initiated BQ after surgery, 36.4% before and completed it afterwards.•90% culture-converted and 69.1% achieved treatment success at the end of treatment.
No study evaluated the contribution of adjunctive surgery in bedaquiline-treated patients. This study describes treatment outcomes and complications in a cohort of drug-resistant pulmonary tuberculosis (TB) cases treated with bedaquiline-containing regimens undergoing surgery.
This retrospective observational study recruited patients treated for TB in 12 centres in 9 countries between January 2007 and March 2015.
Patients who had surgical indications in a bedaquiline-treated programme-based cohort were selected and surgery-related information was collected. Patient characteristics and surgical indications were described together with type of operation, surgical complications, bacteriological conversion rates, and treatment outcomes. Treatment outcomes were evaluated according to the time of surgery.
57 bedaquiline-exposed cases resistant to a median of 7 drugs had indication for surgery (52 retreatments; 50 extensively drug-resistant (XDR) or pre XDR-TB). Sixty percent of cases initiated bedaquiline treatment following surgery, while 36.4% underwent the bedaquiline regimen before surgery and completed it after the operation. At treatment completion 90% culture-converted with 69.1% achieving treatment success; 21.8% had unfavourable outcomes (20.0% treatment failure, 1.8% lost to follow-up), and 9.1% were still undergoing treatment.
The study results suggest that bedaquiline and surgery can be safely and effectively combined in selected cases with a specific indication. |
| doi_str_mv | 10.1016/j.jinf.2018.08.003 |
| format | Article |
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No study evaluated the contribution of adjunctive surgery in bedaquiline-treated patients. This study describes treatment outcomes and complications in a cohort of drug-resistant pulmonary tuberculosis (TB) cases treated with bedaquiline-containing regimens undergoing surgery.
This retrospective observational study recruited patients treated for TB in 12 centres in 9 countries between January 2007 and March 2015.
Patients who had surgical indications in a bedaquiline-treated programme-based cohort were selected and surgery-related information was collected. Patient characteristics and surgical indications were described together with type of operation, surgical complications, bacteriological conversion rates, and treatment outcomes. Treatment outcomes were evaluated according to the time of surgery.
57 bedaquiline-exposed cases resistant to a median of 7 drugs had indication for surgery (52 retreatments; 50 extensively drug-resistant (XDR) or pre XDR-TB). Sixty percent of cases initiated bedaquiline treatment following surgery, while 36.4% underwent the bedaquiline regimen before surgery and completed it after the operation. At treatment completion 90% culture-converted with 69.1% achieving treatment success; 21.8% had unfavourable outcomes (20.0% treatment failure, 1.8% lost to follow-up), and 9.1% were still undergoing treatment.
The study results suggest that bedaquiline and surgery can be safely and effectively combined in selected cases with a specific indication.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2018.08.003</identifier><identifier>PMID: 30096332</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Antitubercular Agents - therapeutic use ; Coinfection - microbiology ; Coinfection - virology ; Diarylquinolines - therapeutic use ; Female ; HIV Infections - complications ; Human health and pathology ; Humans ; Infectious diseases ; Life Sciences ; Male ; Middle Aged ; pulmonary rehabilitation ; Retrospective Studies ; Surgical Procedures, Operative - statistics & numerical data ; TB, MDR-TB ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - surgery ; XDR-TB, surgery</subject><ispartof>The Journal of infection, 2019-01, Vol.78 (1), p.35-39</ispartof><rights>2018 The British Infection Association</rights><rights>Copyright © 2018 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-32d56ddf2061b9561b45538aa3617ddbd77dfed0725694bcc394085a71289b153</citedby><cites>FETCH-LOGICAL-c472t-32d56ddf2061b9561b45538aa3617ddbd77dfed0725694bcc394085a71289b153</cites><orcidid>0000-0001-9424-6551 ; 0000-0002-1600-4474 ; 0000-0003-2257-3099 ; 0000-0002-2597-574X ; 0000-0002-2012-5439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0163445318302469$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30096332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03885992$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:139917458$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Borisov, Sergey E.</creatorcontrib><creatorcontrib>D'Ambrosio, Lia</creatorcontrib><creatorcontrib>Centis, Rosella</creatorcontrib><creatorcontrib>Tiberi, Simon</creatorcontrib><creatorcontrib>Dheda, Keertan</creatorcontrib><creatorcontrib>Alffenaar, Jan-Willem</creatorcontrib><creatorcontrib>Amale, Rohit</creatorcontrib><creatorcontrib>Belilowski, Evgeny</creatorcontrib><creatorcontrib>Bruchfeld, Judith</creatorcontrib><creatorcontrib>Canneto, Barbara</creatorcontrib><creatorcontrib>Denholm, Justin</creatorcontrib><creatorcontrib>Duarte, Raquel</creatorcontrib><creatorcontrib>Esmail, Aliasgar</creatorcontrib><creatorcontrib>Filippov, Alex</creatorcontrib><creatorcontrib>Davies Forsman, Lina</creatorcontrib><creatorcontrib>Gaga, Mina</creatorcontrib><creatorcontrib>Ganatra, Shashank</creatorcontrib><creatorcontrib>Igorevna, Gaida Anastasia</creatorcontrib><creatorcontrib>Lazaro Mastrapa, Barbara</creatorcontrib><creatorcontrib>Manfrin, Vinicio</creatorcontrib><creatorcontrib>Manga, Selene</creatorcontrib><creatorcontrib>Maryandyshev, Andrey</creatorcontrib><creatorcontrib>Massard, Gilbert</creatorcontrib><creatorcontrib>González Montaner, Pablo</creatorcontrib><creatorcontrib>Mullerpattan, Jai</creatorcontrib><creatorcontrib>Palmero, Domingo Juan</creatorcontrib><creatorcontrib>Pontarelli, Agostina</creatorcontrib><creatorcontrib>Papavasileiou, Apostolos</creatorcontrib><creatorcontrib>Pontali, Emanuele</creatorcontrib><creatorcontrib>Romero Leyet, Rodolfo</creatorcontrib><creatorcontrib>Spanevello, Antonio</creatorcontrib><creatorcontrib>Udwadia, Zarir Farokh</creatorcontrib><creatorcontrib>Viggiani, Pietro</creatorcontrib><creatorcontrib>Visca, Dina</creatorcontrib><creatorcontrib>Sotgiu, Giovanni</creatorcontrib><creatorcontrib>Migliori, Giovanni Battista</creatorcontrib><title>Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>•Treating MDR-TB is complicated, long and expensive.•Bedaquiline (BQ) is a new active drug to treat MDR-TB.•No study evaluated safety and effectiveness of surgery in BQ-treated patients.•57 BQ-exposed cases resistant to 7 drugs (median) underwent surgery in 9 countries.•60% of cases initiated BQ after surgery, 36.4% before and completed it afterwards.•90% culture-converted and 69.1% achieved treatment success at the end of treatment.
No study evaluated the contribution of adjunctive surgery in bedaquiline-treated patients. This study describes treatment outcomes and complications in a cohort of drug-resistant pulmonary tuberculosis (TB) cases treated with bedaquiline-containing regimens undergoing surgery.
This retrospective observational study recruited patients treated for TB in 12 centres in 9 countries between January 2007 and March 2015.
Patients who had surgical indications in a bedaquiline-treated programme-based cohort were selected and surgery-related information was collected. Patient characteristics and surgical indications were described together with type of operation, surgical complications, bacteriological conversion rates, and treatment outcomes. Treatment outcomes were evaluated according to the time of surgery.
57 bedaquiline-exposed cases resistant to a median of 7 drugs had indication for surgery (52 retreatments; 50 extensively drug-resistant (XDR) or pre XDR-TB). Sixty percent of cases initiated bedaquiline treatment following surgery, while 36.4% underwent the bedaquiline regimen before surgery and completed it after the operation. At treatment completion 90% culture-converted with 69.1% achieving treatment success; 21.8% had unfavourable outcomes (20.0% treatment failure, 1.8% lost to follow-up), and 9.1% were still undergoing treatment.
The study results suggest that bedaquiline and surgery can be safely and effectively combined in selected cases with a specific indication.</description><subject>Adult</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Coinfection - microbiology</subject><subject>Coinfection - virology</subject><subject>Diarylquinolines - therapeutic use</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pulmonary rehabilitation</subject><subject>Retrospective Studies</subject><subject>Surgical Procedures, Operative - statistics & numerical data</subject><subject>TB, MDR-TB</subject><subject>Treatment Outcome</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - surgery</subject><subject>XDR-TB, surgery</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEokvhD3BAOcIhiz9iJ5G4VFWhSCv1AmfLsSepQ2Jv_bFV7_xwHGWpxAVpNDN69cx7mLco3mO0xwjzz9N-MnbYE4TbPcqF6ItihxklFWlq8rLYZYhWdc3oRfEmhAkh1NGOvy4uaN44pWRX_L5LUbkFQumG8iijARtD-Wjifal9GisPwYQobaxi6sGrNLsslNGDjKA3sActH5KZjYVKORulscaOpYfRLGBDKa0uk9XgR7fqUk_JqmhOUIbkR_BPb4tXg5wDvDvPy-Ln15sf17fV4e7b9-urQ6XqhsSKEs241gNBHPcdy61mjLZSUo4brXvdNHoAjRrCeFf3StGuRi2TDSZt1-fHXBbV5hse4Zh6cfRmkf5JOGnEWfqVNxB1y2lDMv9p4-_l_A98e3UQq4Zo27KuIyec2Y8be_TuIUGIYjFBwTxLCy4FQVDbsK7mHGWUbKjyLgQPw7M3RmJNVkxiTVasyQqUC9F89OHsn_oF9PPJ3ygz8GUDIH_wZMCLoHKaCrTxoKLQzvzP_w9a9rfV</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Borisov, Sergey E.</creator><creator>D'Ambrosio, Lia</creator><creator>Centis, Rosella</creator><creator>Tiberi, Simon</creator><creator>Dheda, Keertan</creator><creator>Alffenaar, Jan-Willem</creator><creator>Amale, Rohit</creator><creator>Belilowski, Evgeny</creator><creator>Bruchfeld, Judith</creator><creator>Canneto, Barbara</creator><creator>Denholm, Justin</creator><creator>Duarte, Raquel</creator><creator>Esmail, Aliasgar</creator><creator>Filippov, Alex</creator><creator>Davies Forsman, Lina</creator><creator>Gaga, Mina</creator><creator>Ganatra, Shashank</creator><creator>Igorevna, Gaida Anastasia</creator><creator>Lazaro Mastrapa, Barbara</creator><creator>Manfrin, Vinicio</creator><creator>Manga, Selene</creator><creator>Maryandyshev, Andrey</creator><creator>Massard, Gilbert</creator><creator>González Montaner, Pablo</creator><creator>Mullerpattan, Jai</creator><creator>Palmero, Domingo Juan</creator><creator>Pontarelli, Agostina</creator><creator>Papavasileiou, Apostolos</creator><creator>Pontali, Emanuele</creator><creator>Romero Leyet, Rodolfo</creator><creator>Spanevello, Antonio</creator><creator>Udwadia, Zarir Farokh</creator><creator>Viggiani, Pietro</creator><creator>Visca, Dina</creator><creator>Sotgiu, Giovanni</creator><creator>Migliori, Giovanni Battista</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0001-9424-6551</orcidid><orcidid>https://orcid.org/0000-0002-1600-4474</orcidid><orcidid>https://orcid.org/0000-0003-2257-3099</orcidid><orcidid>https://orcid.org/0000-0002-2597-574X</orcidid><orcidid>https://orcid.org/0000-0002-2012-5439</orcidid></search><sort><creationdate>201901</creationdate><title>Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery</title><author>Borisov, Sergey E. ; D'Ambrosio, Lia ; Centis, Rosella ; Tiberi, Simon ; Dheda, Keertan ; Alffenaar, Jan-Willem ; Amale, Rohit ; Belilowski, Evgeny ; Bruchfeld, Judith ; Canneto, Barbara ; Denholm, Justin ; Duarte, Raquel ; Esmail, Aliasgar ; Filippov, Alex ; Davies Forsman, Lina ; Gaga, Mina ; Ganatra, Shashank ; Igorevna, Gaida Anastasia ; Lazaro Mastrapa, Barbara ; Manfrin, Vinicio ; Manga, Selene ; Maryandyshev, Andrey ; Massard, Gilbert ; González Montaner, Pablo ; Mullerpattan, Jai ; Palmero, Domingo Juan ; Pontarelli, Agostina ; Papavasileiou, Apostolos ; Pontali, Emanuele ; Romero Leyet, Rodolfo ; Spanevello, Antonio ; Udwadia, Zarir Farokh ; Viggiani, Pietro ; Visca, Dina ; Sotgiu, Giovanni ; Migliori, Giovanni Battista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-32d56ddf2061b9561b45538aa3617ddbd77dfed0725694bcc394085a71289b153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Antitubercular Agents - 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No study evaluated the contribution of adjunctive surgery in bedaquiline-treated patients. This study describes treatment outcomes and complications in a cohort of drug-resistant pulmonary tuberculosis (TB) cases treated with bedaquiline-containing regimens undergoing surgery.
This retrospective observational study recruited patients treated for TB in 12 centres in 9 countries between January 2007 and March 2015.
Patients who had surgical indications in a bedaquiline-treated programme-based cohort were selected and surgery-related information was collected. Patient characteristics and surgical indications were described together with type of operation, surgical complications, bacteriological conversion rates, and treatment outcomes. Treatment outcomes were evaluated according to the time of surgery.
57 bedaquiline-exposed cases resistant to a median of 7 drugs had indication for surgery (52 retreatments; 50 extensively drug-resistant (XDR) or pre XDR-TB). Sixty percent of cases initiated bedaquiline treatment following surgery, while 36.4% underwent the bedaquiline regimen before surgery and completed it after the operation. At treatment completion 90% culture-converted with 69.1% achieving treatment success; 21.8% had unfavourable outcomes (20.0% treatment failure, 1.8% lost to follow-up), and 9.1% were still undergoing treatment.
The study results suggest that bedaquiline and surgery can be safely and effectively combined in selected cases with a specific indication.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30096332</pmid><doi>10.1016/j.jinf.2018.08.003</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9424-6551</orcidid><orcidid>https://orcid.org/0000-0002-1600-4474</orcidid><orcidid>https://orcid.org/0000-0003-2257-3099</orcidid><orcidid>https://orcid.org/0000-0002-2597-574X</orcidid><orcidid>https://orcid.org/0000-0002-2012-5439</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2019-01, Vol.78 (1), p.35-39 |
| issn | 0163-4453 1532-2742 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_486372 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Antitubercular Agents - therapeutic use Coinfection - microbiology Coinfection - virology Diarylquinolines - therapeutic use Female HIV Infections - complications Human health and pathology Humans Infectious diseases Life Sciences Male Middle Aged pulmonary rehabilitation Retrospective Studies Surgical Procedures, Operative - statistics & numerical data TB, MDR-TB Treatment Outcome Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - surgery XDR-TB, surgery |
| title | Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T18%3A46%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcomes%20of%20patients%20with%20drug-resistant-tuberculosis%20treated%20with%20bedaquiline-containing%20regimens%20and%20undergoing%20adjunctive%20surgery&rft.jtitle=The%20Journal%20of%20infection&rft.au=Borisov,%20Sergey%20E.&rft.date=2019-01&rft.volume=78&rft.issue=1&rft.spage=35&rft.epage=39&rft.pages=35-39&rft.issn=0163-4453&rft.eissn=1532-2742&rft_id=info:doi/10.1016/j.jinf.2018.08.003&rft_dat=%3Cproquest_swepu%3E2087594660%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2087594660&rft_id=info:pmid/30096332&rft_els_id=S0163445318302469&rfr_iscdi=true |