SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

Abstract Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate...

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Veröffentlicht in:	Nucleic acids research 2018-10, Vol.46 (18), p.9484-9495
Hauptverfasser:	Hjorth-Jensen, Kim, Maya-Mendoza, Apolinar, Dalgaard, Nanna, Sigurðsson, Jón O, Bartek, Jiri, Iglesias-Gato, Diego, Olsen, Jesper V, Flores-Morales, Amilcar
Format:	Artikel
Sprache:	eng
Schlagworte:	Genome Integrity, Repair and Medicin och hälsovetenskap
Online-Zugang:	Volltext
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