A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Three linked microfluidic chips model transport across the blood–brain barrier. The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes and conversions over the NVU rely on interactions between...

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Veröffentlicht in:	Nature biotechnology 2018-10, Vol.36 (9), p.865-874
Hauptverfasser:	Maoz, Ben M, Herland, Anna, FitzGerald, Edward A, Grevesse, Thomas, Vidoudez, Charles, Pacheco, Alan R, Sheehy, Sean P, Park, Tae-Eun, Dauth, Stephanie, Mannix, Robert, Budnik, Nikita, Shores, Kevin, Cho, Alexander, Nawroth, Janna C, Segrè, Daniel, Budnik, Bogdan, Ingber, Donald E, Parker, Kevin Kit
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 101/62 13/107 49 631/1647/277 631/1647/767/1658 631/378/2607 82/47 82/58 82/80 9/10 96/106 Agriculture Amino acids Astrocytes Biochips Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Blood-brain barrier Blood-Brain Barrier - drug effects Brain Cell metabolism Central nervous system Coupling Drug abuse Efflux Endothelial Cells - metabolism Endothelium Fluxes Hallucinogenic drugs Homeostasis Humans Lab-On-A-Chip Devices Life Sciences Metabolism Methamphetamine Methamphetamine - pharmacology Microfluidics Microvasculature Neurons Neurons - metabolism Neurophysiology Pericytes Pharmacodynamics Pharmacokinetics Pharmacology Phenotype Physiological aspects Psychotropic drugs Toxicity
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