Y chromosome mosaicism is associated with age-related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be...

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Veröffentlicht in:	European journal of human genetics : EJHG 2019-01, Vol.27 (1), p.36-41
Hauptverfasser:	Grassmann, Felix, Kiel, Christina, den Hollander, Anneke I, Weeks, Daniel E, Lotery, Andrew, Cipriani, Valentina, Weber, Bernhard H F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Alzheimer's disease Blindness Blood cells Chromosome Deletion Chromosomes Chromosomes, Human, Y - genetics Genetic factors Genomes Genotyping Humans Macular degeneration Macular Degeneration - genetics Male Mosaicism Neurodegenerative diseases Peripheral blood Quality control Smoking Y Chromosomes
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