Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

Ribonucleotide reductase (RNR) catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis 1 , 2 . It is essential for all organisms that use DNA as their genetic material and is a current drug target 3 , 4 . Since the discovery th...

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Veröffentlicht in:	Nature (London) 2018-11, Vol.563 (7731), p.416-420
Hauptverfasser:	Srinivas, Vivek, Lebrette, Hugo, Lundin, Daniel, Kutin, Yuri, Sahlin, Margareta, Lerche, Michael, Eirich, Jürgen, Branca, Rui M. M., Cox, Nicholas, Sjöberg, Britt-Marie, Högbom, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/173 631/45/49 631/45/607/1168 631/535/1266 82/80 82/83 Amino Acid Sequence Antibiotics Bacteria Biochemistry Biokemi Catalysis Data analysis Deoxyribonucleic acid Deoxyribonucleotides Dihydroxyphenylalanine Dihydroxyphenylalanine - chemistry Dihydroxyphenylalanine - metabolism DNA DNA biosynthesis E coli Enzymes Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Eukaryotes Humanities and Social Sciences Immune system Immune System - metabolism Iron Iron - metabolism L-dopa Letter Mass spectrometry Metals Metals - metabolism Microbial drug resistance Models, Molecular multidisciplinary Mycoplasma Mycoplasma - drug effects Mycoplasma - enzymology Mycoplasma - genetics Mycoplasma - metabolism Operon - genetics Organic chemistry Oxidation Oxidation-Reduction Pathogenic microorganisms Pathogens Phenols (Class of compounds) Physiological aspects Proteins Proteomics Reductase Reduction Reduction (metal working) Resveratrol Ribonucleotide reductase Ribonucleotide Reductases - chemistry Ribonucleotide Reductases - metabolism Ribonucleotides - chemistry Ribonucleotides - metabolism Science Science (multidisciplinary) Scientific imaging Structural analysis Tyrosine Tyrosine - chemistry Tyrosine - metabolism
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