A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes

Abstract Aims Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing ‘real-world’ data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adv...

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Veröffentlicht in:European heart journal 2019-03, Vol.40 (10), p.820-830
Hauptverfasser: Holmqvist, Fredrik, Kesek, Milos, Englund, Anders, Blomström-Lundqvist, Carina, Karlsson, Lars O, Kennebäck, Göran, Poçi, Dritan, Samo-Ayou, Romeo, Sigurjónsdóttir, Runa, Ringborn, Michael, Herczku, Csaba, Carlson, Jonas, Fengsrud, Espen, Tabrizi, Fariborz, Höglund, Niklas, Lönnerholm, Stefan, Kongstad, Ole, Jönsson, Anders, Insulander, Per
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container_end_page 830
container_issue 10
container_start_page 820
container_title European heart journal
container_volume 40
creator Holmqvist, Fredrik
Kesek, Milos
Englund, Anders
Blomström-Lundqvist, Carina
Karlsson, Lars O
Kennebäck, Göran
Poçi, Dritan
Samo-Ayou, Romeo
Sigurjónsdóttir, Runa
Ringborn, Michael
Herczku, Csaba
Carlson, Jonas
Fengsrud, Espen
Tabrizi, Fariborz
Höglund, Niklas
Lönnerholm, Stefan
Kongstad, Ole
Jönsson, Anders
Insulander, Per
description Abstract Aims Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing ‘real-world’ data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported. Methods and Results Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff–Parkinson–White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7–7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P 
doi_str_mv 10.1093/eurheartj/ehy709
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Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported. Methods and Results Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff–Parkinson–White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7–7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P &lt; 0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3 years). The rate of reported adverse events was low (n = 595, 1.7%). Death in the immediate period following ablation was rare (n = 116, 0.34%). Conclusion Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.</description><identifier>ISSN: 0195-668X</identifier><identifier>ISSN: 1522-9645</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehy709</identifier><identifier>PMID: 30452631</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Adverse events ; Aged ; Arrhythmias, Cardiac - epidemiology ; Arrhythmias, Cardiac - surgery ; Cardiac and Cardiovascular Systems ; Cardiology ; Catheter ablation ; Catheter Ablation - adverse effects ; Catheter Ablation - statistics &amp; numerical data ; Clinical Medicine ; Clinical Research ; Cohort Studies ; Editor's Choice ; Female ; Humans ; Kardiologi ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Outcome ; Reoperation - statistics &amp; numerical data ; Sweden - epidemiology ; Treatment Outcome</subject><ispartof>European heart journal, 2019-03, Vol.40 (10), p.820-830</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c689t-9e6bdbe2fba8c7121981d1d26c09fa60d22fd9e66b6c82fdf655070114fba26e3</citedby><cites>FETCH-LOGICAL-c689t-9e6bdbe2fba8c7121981d1d26c09fa60d22fd9e66b6c82fdf655070114fba26e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,551,777,781,882,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30452631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155897$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73403$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367225$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/273263$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/c17c5d19-05bf-484c-a1a7-a8b1534e1133$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:140539403$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmqvist, Fredrik</creatorcontrib><creatorcontrib>Kesek, Milos</creatorcontrib><creatorcontrib>Englund, Anders</creatorcontrib><creatorcontrib>Blomström-Lundqvist, Carina</creatorcontrib><creatorcontrib>Karlsson, Lars O</creatorcontrib><creatorcontrib>Kennebäck, Göran</creatorcontrib><creatorcontrib>Poçi, Dritan</creatorcontrib><creatorcontrib>Samo-Ayou, Romeo</creatorcontrib><creatorcontrib>Sigurjónsdóttir, Runa</creatorcontrib><creatorcontrib>Ringborn, Michael</creatorcontrib><creatorcontrib>Herczku, Csaba</creatorcontrib><creatorcontrib>Carlson, Jonas</creatorcontrib><creatorcontrib>Fengsrud, Espen</creatorcontrib><creatorcontrib>Tabrizi, Fariborz</creatorcontrib><creatorcontrib>Höglund, Niklas</creatorcontrib><creatorcontrib>Lönnerholm, Stefan</creatorcontrib><creatorcontrib>Kongstad, Ole</creatorcontrib><creatorcontrib>Jönsson, Anders</creatorcontrib><creatorcontrib>Insulander, Per</creatorcontrib><creatorcontrib>Sahlgrenska akademin</creatorcontrib><creatorcontrib>Institute of Medicine, Department of Molecular and Clinical Medicine</creatorcontrib><creatorcontrib>Institutionen för medicin, avdelningen för molekylär och klinisk medicin</creatorcontrib><creatorcontrib>Göteborgs universitet</creatorcontrib><creatorcontrib>Gothenburg University</creatorcontrib><creatorcontrib>Sahlgrenska Academy</creatorcontrib><title>A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Abstract Aims Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing ‘real-world’ data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported. Methods and Results Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff–Parkinson–White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7–7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P &lt; 0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3 years). The rate of reported adverse events was low (n = 595, 1.7%). Death in the immediate period following ablation was rare (n = 116, 0.34%). Conclusion Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.</description><subject>Adult</subject><subject>Adverse events</subject><subject>Aged</subject><subject>Arrhythmias, Cardiac - epidemiology</subject><subject>Arrhythmias, Cardiac - surgery</subject><subject>Cardiac and Cardiovascular Systems</subject><subject>Cardiology</subject><subject>Catheter ablation</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - statistics &amp; numerical data</subject><subject>Clinical Medicine</subject><subject>Clinical Research</subject><subject>Cohort Studies</subject><subject>Editor's Choice</subject><subject>Female</subject><subject>Humans</subject><subject>Kardiologi</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Outcome</subject><subject>Reoperation - statistics &amp; numerical data</subject><subject>Sweden - epidemiology</subject><subject>Treatment Outcome</subject><issn>0195-668X</issn><issn>1522-9645</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk1v1DAQhiMEokvhzgnliAShHjt2Yg5Iq_IprcSBD3GzHHuyccnGWzuh2n-PlywLPbRwGNkaP-8749Fk2WMgL4BIdoZT6FCH8eIMu11F5J1sAZzSQoqS380WBCQvhKi_nWQPYrwghNQCxP3shJGSU8FgkallbtFoi7lvc6PHDkcMuW56PTo_zMlgnTa5DqHbjd3G6Zi7If90hRaHl3_QbdBmdAZjrgeb-2k0foPxYXav1X3ER4fzNPvy9s3n8_fF6uO7D-fLVWFELcdComhsg7RtdG0qoCBrsGCpMES2WhBLaWsTJBph6nRtBeekIgBlUlCB7DQrZt94hdupUdvgNjrslNdOHVLf0w1VWZeEicSvbuT7aZuiSbEXGKgMtyAV4U27lxulQVdK1w1wViIAY7eWXye7lFr_cqMVS4NP_PMb-dfu61L5sFbTpJioKOX_h_swqYql393azRHv3aSA81pWiX818wneoDU4jEH312TXXwbXqbX_oUSqVnKZDJ4eDIK_nDCOauOiwb7XA_opKgpMEFHxct8bmVETfIwB22MZIGq_1Oq41Gpe6iR58nd7R8HvLU7AsxnwadT_tPsJZJ8JWw</recordid><startdate>20190307</startdate><enddate>20190307</enddate><creator>Holmqvist, Fredrik</creator><creator>Kesek, Milos</creator><creator>Englund, Anders</creator><creator>Blomström-Lundqvist, Carina</creator><creator>Karlsson, Lars O</creator><creator>Kennebäck, Göran</creator><creator>Poçi, Dritan</creator><creator>Samo-Ayou, Romeo</creator><creator>Sigurjónsdóttir, Runa</creator><creator>Ringborn, Michael</creator><creator>Herczku, Csaba</creator><creator>Carlson, Jonas</creator><creator>Fengsrud, Espen</creator><creator>Tabrizi, Fariborz</creator><creator>Höglund, Niklas</creator><creator>Lönnerholm, Stefan</creator><creator>Kongstad, Ole</creator><creator>Jönsson, Anders</creator><creator>Insulander, Per</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ABXSW</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG8</scope><scope>ZZAVC</scope><scope>AABEP</scope><scope>D91</scope><scope>ACNBI</scope><scope>DF2</scope><scope>F1U</scope><scope>AGCHP</scope><scope>D95</scope></search><sort><creationdate>20190307</creationdate><title>A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes</title><author>Holmqvist, Fredrik ; Kesek, Milos ; Englund, Anders ; Blomström-Lundqvist, Carina ; Karlsson, Lars O ; Kennebäck, Göran ; Poçi, Dritan ; Samo-Ayou, Romeo ; Sigurjónsdóttir, Runa ; Ringborn, Michael ; Herczku, Csaba ; Carlson, Jonas ; Fengsrud, Espen ; Tabrizi, Fariborz ; Höglund, Niklas ; Lönnerholm, Stefan ; Kongstad, Ole ; Jönsson, Anders ; Insulander, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c689t-9e6bdbe2fba8c7121981d1d26c09fa60d22fd9e66b6c82fdf655070114fba26e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Adverse events</topic><topic>Aged</topic><topic>Arrhythmias, Cardiac - epidemiology</topic><topic>Arrhythmias, Cardiac - surgery</topic><topic>Cardiac and Cardiovascular Systems</topic><topic>Cardiology</topic><topic>Catheter ablation</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - statistics &amp; numerical data</topic><topic>Clinical Medicine</topic><topic>Clinical Research</topic><topic>Cohort Studies</topic><topic>Editor's Choice</topic><topic>Female</topic><topic>Humans</topic><topic>Kardiologi</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Outcome</topic><topic>Reoperation - statistics &amp; 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Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported. Methods and Results Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff–Parkinson–White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7–7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P &lt; 0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3 years). The rate of reported adverse events was low (n = 595, 1.7%). Death in the immediate period following ablation was rare (n = 116, 0.34%). Conclusion Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30452631</pmid><doi>10.1093/eurheartj/ehy709</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0195-668X
ispartof European heart journal, 2019-03, Vol.40 (10), p.820-830
issn 0195-668X
1522-9645
1522-9645
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Adult
Adverse events
Aged
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - surgery
Cardiac and Cardiovascular Systems
Cardiology
Catheter ablation
Catheter Ablation - adverse effects
Catheter Ablation - statistics & numerical data
Clinical Medicine
Clinical Research
Cohort Studies
Editor's Choice
Female
Humans
Kardiologi
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Outcome
Reoperation - statistics & numerical data
Sweden - epidemiology
Treatment Outcome
title A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes
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