The association between neonatal vitamin D status and risk of schizophrenia
Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The...
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| creator | Eyles, Darryl W. Trzaskowski, Maciej Vinkhuyzen, Anna A. E. Mattheisen, Manuel Meier, Sandra Gooch, Helen Anggono, Victor Cui, Xiaoying Tan, Men Chee Burne, Thomas H. J. Jang, Se Eun Kvaskoff, David Hougaard, David M. Nørgaard-Pedersen, Bent Cohen, Arieh Agerbo, Esben Pedersen, Carsten B. Børglum, Anders D. Mors, Ole Sah, Pankaj Wray, Naomi R. Mortensen, Preben B. McGrath, John J. |
| description | Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013). Compared to the reference (fourth) quintile, those in the lowest quintile ( |
| doi_str_mv | 10.1038/s41598-018-35418-z |
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E. ; Mattheisen, Manuel ; Meier, Sandra ; Gooch, Helen ; Anggono, Victor ; Cui, Xiaoying ; Tan, Men Chee ; Burne, Thomas H. J. ; Jang, Se Eun ; Kvaskoff, David ; Hougaard, David M. ; Nørgaard-Pedersen, Bent ; Cohen, Arieh ; Agerbo, Esben ; Pedersen, Carsten B. ; Børglum, Anders D. ; Mors, Ole ; Sah, Pankaj ; Wray, Naomi R. ; Mortensen, Preben B. ; McGrath, John J.</creator><creatorcontrib>Eyles, Darryl W. ; Trzaskowski, Maciej ; Vinkhuyzen, Anna A. E. ; Mattheisen, Manuel ; Meier, Sandra ; Gooch, Helen ; Anggono, Victor ; Cui, Xiaoying ; Tan, Men Chee ; Burne, Thomas H. J. ; Jang, Se Eun ; Kvaskoff, David ; Hougaard, David M. ; Nørgaard-Pedersen, Bent ; Cohen, Arieh ; Agerbo, Esben ; Pedersen, Carsten B. ; Børglum, Anders D. ; Mors, Ole ; Sah, Pankaj ; Wray, Naomi R. ; Mortensen, Preben B. ; McGrath, John J.</creatorcontrib><description>Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013). Compared to the reference (fourth) quintile, those in the lowest quintile (<20.4 nmol/L) had a significantly increased risk of schizophrenia (IRR = 1.44, 95%CI: 1.12–1.85). None of the other quintile comparisons were significantly different. There was no significant interaction between 25OHD and the PRS. Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life. 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E. ; Mattheisen, Manuel ; Meier, Sandra ; Gooch, Helen ; Anggono, Victor ; Cui, Xiaoying ; Tan, Men Chee ; Burne, Thomas H. 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J.</au><au>Jang, Se Eun</au><au>Kvaskoff, David</au><au>Hougaard, David M.</au><au>Nørgaard-Pedersen, Bent</au><au>Cohen, Arieh</au><au>Agerbo, Esben</au><au>Pedersen, Carsten B.</au><au>Børglum, Anders D.</au><au>Mors, Ole</au><au>Sah, Pankaj</au><au>Wray, Naomi R.</au><au>Mortensen, Preben B.</au><au>McGrath, John J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between neonatal vitamin D status and risk of schizophrenia</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-12-06</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>17692</spage><epage>8</epage><pages>17692-8</pages><artnum>17692</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. 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| subjects | 25-Hydroxyvitamin D 692/308/174 692/499 Epidemiology Humanities and Social Sciences Hypotheses Mathematical models Mental disorders multidisciplinary Neonates Public health Schizophrenia Science Science (multidisciplinary) Statistical analysis Statistical models Vitamin D Vitamin deficiency |
| title | The association between neonatal vitamin D status and risk of schizophrenia |
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