Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis

Dimethyl fumarate (DMF) is an important oral treatment option for various autoimmune diseases, such as multiple sclerosis (MS) and psoriasis. DMF and its dynamic metabolite, monomethyl fumarate (MMF) are the major compounds that exert therapeutic effects on several pathologic conditions in part, thr...

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Veröffentlicht in:	Journal of cellular physiology 2019-07, Vol.234 (7), p.9943-9955
Hauptverfasser:	Hosseini, Arezoo, Masjedi, Ali, Baradaran, Behzad, Hojjat‐Farsangi, Mohammad, Ghalamfarsa, Ghasem, Anvari, Enayat, Jadidi‐Niaragh, Farhad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - drug effects Adaptive systems Animals Antioxidants Autoimmune diseases Carboxylic acids Chemical compounds Dendritic cells dimethyl fumarate Dimethyl Fumarate - adverse effects Dimethyl Fumarate - pharmacokinetics Dimethyl Fumarate - therapeutic use Humans Immune system Immune System - drug effects Immune System - immunology Immune System - physiopathology Immunity, Innate - drug effects Immunopathogenesis Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Leukocytes (neutrophilic) Lymphocytes Lymphocytes B Lymphocytes T Macrophages Metabolites Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology Natural killer cells Pharmacology Psoriasis Signal Transduction Skin diseases Translocation treatment
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